Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children

Kim, Woo Kyung; Kwon, Ji‐Won; Seo, Ju‐Hee; Kim, Hyung Young; Yu, Jinho; Kim, Byoung-Ju; Kim, Hyo-Bin; Lee, So Yeon; Kim, Kyung Won; Kang, Mi‐Jin; Shin, Yee-Jin; Hong, Soo‐Jong

doi:10.1016/j.jaci.2012.04.052

Cited by 50 publications

(48 citation statements)

References 37 publications

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“…4,8,16,30) In the present study, parental history of AD was the only significant familial risk factor for AD in preschool children; parental histories of other allergic diseases such as asthma and allergic rhinitis were not significant.…”

Section: Discussioncontrasting

confidence: 45%

“…The rapid increase in the prevalence of AD over the last 30 to 40 years suggests that environmental factors rather than genetic effects are responsible for this increased prevalence, although interactions between genetic and environmental factors may also be important. [6][7][8] Recent clinical research has therefore focused on identifying gene-environment interactions that contribute to the development of allergic diseases including AD. 4,[8][9][10][11][12][13] Household moisture and mold are associated with adverse health effects in children, 14,15) and mold is considered as a key indoor environmental exposure.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] Recent clinical research has therefore focused on identifying gene-environment interactions that contribute to the development of allergic diseases including AD. 4,[8][9][10][11][12][13] Household moisture and mold are associated with adverse health effects in children, 14,15) and mold is considered as a key indoor environmental exposure. 16) Previously we reported early life exposure to mold was important risk factor for the development of AD especially in susceptible children.…”

Section: Introductionmentioning

confidence: 99%

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Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Kim

Jung

Hong

et al. 2013

Allergy Asthma Respir Dis

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Purpose: Genetic factors and environmental exposures are recognized as important risk factors for atopic dermatitis (AD) in children. Inflammatory responses by molds can be mediated via Toll-like receptor 4 (TLR4). The aims of this study were to investigate mold as risk factor of AD and gene-environment interaction on AD in preschool children. Methods: We undertook a cross-sectional survey with 986 preschool children. We investigated five mold exposure measures (dampness stain, dampness damage, visible mold, mold odor, and house repair). The TLR4 polymorphism (rs1927911) was genotyped by TaqMan assay. Results: The prevalence of AD was as follows: AD diagnosis by questionnaire, 35.1%; current AD (lifetime diagnosis together with symptoms in the last 12 months), 21.5%. When children with parental history of AD were exposed to mold odor during infancy and house repair during the last 12 months, the risk for current AD (adjusted odds ratio [aOR], 6.826; 95% confidence interval [CI], 2.511 to 18.554 vs. aOR, 6.143; 95% CI, 2.348 to 16.074) was further increased than only with parental history of AD. In children with the CC genotype of TLR4 polymorphism, the risk of AD was increased by mold exposure. Conclusion: This investigation identified that mold exposure is potential risk factor for AD in preschool children. Parental history of AD and mold exposure during infancy and the last 12 months had synergistic effect on high prevalence of AD. We identified that mold exposure andTLR4 polymorphism have an effect on the development of atopic dermatitis. (��

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Section: Discussioncontrasting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Kim

Jung

Hong

et al. 2013

Allergy Asthma Respir Dis

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“…It has been shown that the underlying mechanisms of AR comprise both genetic and environmental factors 30,31 and some inherited susceptibility genes with SNPs may exert their effects in AR development. 32,33 Up to now, several studies on the association between ACE I/D polymorphism and atopic disorders have been reported.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects

Lin

Zheng

2013

J Renin Angiotensin Aldosterone Syst

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Background and objective: Whether the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene increases susceptibility to allergic rhinitis (AR) is still undetermined. Therefore, this meta-analysis was performed to systematically assess the possible association between them. Methods: The OVID, Medline, Embase, Web of Science, CNKI and Wangfang databases were searched to identify the eligible studies focusing on the association between ACE I/D polymorphism and susceptibility to AR. Results: A total of 1410 subjects from six studies were subjected to meta-analysis. In the overall analysis, ACE I/D polymorphism had a statistically significant association with increased AR risk under all genetic models (p<0.05). In the subgroup analysis by ethnicity, significant elevated AR risks were associated with ACE I/D polymorphism in Asians under all genetic models (p<0.05) and in Caucasians under under allele contrast, homozygous comparison and recessive models (p<0.05). In the subgroup analysis by age, ACE I/D polymorphism was associated with significant elevated risks of AR in adults (p<0.05) but not in children (p>0.05) under all genetic models. Conclusions:The ACE I/D polymorphism may be a risk factor for AR and studies with large sample size and representative population are warranted to verify this finding.

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“…Exposure to environmental factors in early life increases the risk for allergic disease in individuals with a susceptible genotype. [14][15][16][17] However, there is limited information on the interaction between environmental factors in prenatal periods and genes that affect CB immune response.…”

Section: The Interaction Between Prenatal Exposure To Home Renovationmentioning

confidence: 99%

The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy

Ahn

Shin

et al. 2016

Allergy Asthma Immunol Res

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose: Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to home renovation and cord blood (CB) IgE response. The aims of this study were to identify the effect of prenatal exposure to home renovation on CB IgE levels, and to investigate whether this exposure interacts with neonatal genes and whether the effect can be modified by maternal atopy. Methods: This study included 1,002 mother-neonate pairs from the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). Prenatal environmental factors were collected using a questionnaire. The levels of CB IgE were measured by the ImmunoCAP system, and DNA was extracted from CB. Results: Exposure to home renovation during the prenatal period was associated with significantly higher levels of CB IgE only in neonates from atopic mothers, and the effect of renovation exposure on CB IgE levels persisted from 31 months before birth. Furthermore, prenatal exposure to home renovation increased the risk of CB IgE response interacting with polymorphisms of NRF2 and GSTP1 genes only in neonates from atopic mothers. Conclusions: Maternal atopy modified the effect of prenatal exposure to home renovation on CB serum IgE response as well as the interaction between the exposure and neonatal genes involved in the oxidative stress pathway. These findings suggest that the genetically susceptible offspring of atopic mothers may be more vulnerable to the effect of prenatal exposure to home renovation on the development of allergy.

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Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children

Cited by 50 publications

References 37 publications

Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects

The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy

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