The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy

Abstract

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose: Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to home renovation and cord blood (CB) IgE response. The aims of this study were to identify the effect of prenatal exposure to home renovation on CB IgE levels, and to investigate whether this exposure interacts with neonatal genes and whether the effect can be modified by maternal atopy. Methods: This study included 1,002 mother-neonate pairs from the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). Prenatal environmental factors were collected using a questionnaire. The levels of CB IgE were measured by the ImmunoCAP system, and DNA was extracted from CB. Results: Exposure to home renovation during the prenatal period was associated with significantly higher levels of CB IgE only in neonates from atopic mothers, and the effect of renovation exposure on CB IgE levels persisted from 31 months before birth. Furthermore, prenatal exposure to home renovation increased the risk of CB IgE response interacting with polymorphisms of NRF2 and GSTP1 genes only in neonates from atopic mothers. Conclusions: Maternal atopy modified the effect of prenatal exposure to home renovation on CB serum IgE response as well as the interaction between the exposure and neonatal genes involved in the oxidative stress pathway. These findings suggest that the genetically susceptible offspring of atopic mothers may be more vulnerable to the effect of prenatal exposure to home renovation on the development of allergy.

Associations between household renovation and rhinitis among preschool children in China: A cross‐sectional study

“…Exposure to household renovation during the prenatal period was associated with significantly higher levels of cord blood IgE. Household renovation before pregnancy has also been shown to be associated with higher levels of IgE in neonates, a potential biomarker of infant allergic rhinitis 43 . Air pollutants such as indoor smoke, 44 phthalate esters, 45,46 and volatile organic compounds 47 have also been shown to be associated with higher concentrations of total blood IgE.…”

Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children

“…One study in a predominantly black sample reported that three IL13 SNPs (rs1295686, rs1800925 and rs206974) could jointly influence CBIgE concentration [3]. One study in a birth cohort in Korea identified interactions between reactive oxygen species genes, prenatal exposure to home renovation and maternal atopy on CBIgE response [28]. Another study, in a Chinese population in Taiwan, found that IL13 rs20541, male sex and prenatal environmental tobacco smoke interacted on antenatal IgE production [5].…”

High prevalence of eczema among preschool children related to home renovation in China: A multi‐city‐based cross‐sectional study

“…Several studies have been conducted to test the hypothesis that home renovation increases the risk of childhood eczema. Exposure to home renovation during the prenatal period has been found to be associated with significantly higher levels of cord blood IgE . Home renovation before pregnancy has also been investigated as potentially associated with incidence of atopic dermatitis in infants with higher levels of IgE .…”