Interaction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weight

Lee, Boeun; Hong, Yun–Chul; Park, Hyesook; Ha, Mina; Koo, Bon Sang; Chang, Namsoo; Roh, Yun Ho; Kim, Boong-Nyun; Kim, Young‐Ju; Kim, Byungmi; Jo, Seong-Joon; Ha, Eun–Hee

doi:10.1289/0900731

Cited by 65 publications

(27 citation statements)

References 52 publications

(54 reference statements)

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“…Our data corroborate the findings of Lee et al (2010), who evaluated 417 North Korean pregnant women exposed to MeHg via consumption of contaminated fish and demonstrated that women with the GSTM1 * 0 and GSTT1 * 0 polymorphisms presented higher Hg concentrations in both maternal blood and in umbilical cord blood of respective newborns. Klautau-Guimarães et al (2005) studied an Amazon Amerindian population and found the same correlation with individuals who carry null genotypes of GSTM1 presenting higher B-Hg concentrations than those who carry the wild genotype.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Barcelos

Marco

Grotto

et al. 2012

Journal of Toxicology and Environmental Health, Part A

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Section: Discussionsupporting

confidence: 91%

Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Barcelos

Marco

Grotto

et al. 2012

Journal of Toxicology and Environmental Health, Part A

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“…Hg excretion rates vary widely among individuals and involve glutathione conjugation by GST (51) . The results showed that the negative association with birth weight was stronger among women with the GSTM1 null genotype or with both GSTM1 and GSTT1 null genotypes (26) . Our finding of a negative association between maternal exposure to Hg during pregnancy and birth weight is in accordance with a study from a birth cohort in Spain, where high cord blood THg concentrations were inversely related with birth weight (24) .…”

Section: Discussionmentioning

confidence: 92%

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Vejrup

Brantsæter

Knutsen

et al. 2013

Public Health Nutr.

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Objective: To examine the association between calculated maternal dietary exposure to Hg in pregnancy and infant birth weight in the Norwegian Mother and Child Cohort Study (MoBa). Design: Exposure was calculated with use of a constructed database of Hg in food items and reported dietary intake during pregnancy. Multivariable regression models were used to explore the association between maternal Hg exposure and infant birth weight, and to model associations with small-for-gestational-age offspring. Setting: The study is based on data from MoBa. Subjects: The study sample consisted of 62 941 women who answered a validated FFQ which covered the habitual diet during the first five months of pregnancy. Results: Median exposure to Hg was 0?15 mg/kg body weight per week and the contribution from seafood intake was 88 % of total Hg exposure. Women in the highest quintile compared with the lowest quintile of Hg exposure delivered offspring with 34 g lower birth weight (95 % CI 246 g, 222 g) and had an increased risk of giving birth to small-for-gestational-age offspring, adjusted OR 5 1?19 (95 % CI 1?08, 1?30). Although seafood intake was positively associated with increased birth weight, stratified analyses showed negative associations between Hg exposure and birth weight within strata of seafood intake. Conclusions: Although seafood intake in pregnancy is positively associated with birth weight, Hg exposure is negatively associated with birth weight. Seafood consumption during pregnancy should not be avoided, but clarification is needed to identify at what level of Hg exposure this risk might exceed the benefits of seafood.

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“…cific coast subpopulations in China, [148][149][150][151] Japan, [153][154][155][156][157][158][159][160] Peru, 172 the Republic of Korea, [161][162][163][164][165][166][167][168][169][170][171] …”

Section: Systematic Reviewsmentioning

confidence: 99%

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

Sheehan

Burke

Navas‐Acien

et al. 2014

Bull. World Health Organ.

232

124

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Interaction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weight

Cited by 65 publications

References 52 publications

Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

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