Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Barcelos, Gustavo Rafael Mazzaron; Marco, Kátia Cristina de; Grotto, Denise; Valentini, Juliana; Garcia, Solange Cristina; Braga, Gilberto Úbila Leite; Barbosa, Fernando

doi:10.1080/15287394.2012.695232

Cited by 24 publications

(14 citation statements)

References 50 publications

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“…Exposure to metals in the Amazon region, mainly to MeHg, but also to Pb has been the subject of several studies Barcelos et al, 2012;Carneiro et al, 2013; and results obtained in the present work give further support to the occurrence of high exposure to these metals in riverside populations of Amazonian region, Brazil. The high Hg exposure in riparian Amazonian populations is evidenced when compared with other exposed populations.…”

Section: Discussionsupporting

confidence: 84%

Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb

Barcelos

Souza

Oliveira

et al. 2015

Environmental Research

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Section: Discussionsupporting

confidence: 84%

Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb

Barcelos

Souza

Oliveira

et al. 2015

Environmental Research

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“…According to the year of publication, the articles were published as follows: three in 1998 [ 16 , 17 , 18 ], two in 1999 [ 19 , 20 ], three in 2000 [ 21 , 22 , 23 ], two in 2001 [ 24 , 25 ], one in 2002 [ 26 ], two in 2003 [ 27 , 28 ], four in 2005 [ 29 , 30 , 31 , 32 ], three in 2006 [ 33 , 34 , 35 ], two in 2007 [ 36 , 37 ], one in 2008 [ 38 ], one in 2009 [ 39 ], two in 2010 [ 40 , 41 ], three in 2012 [ 42 , 43 , 44 ], one in 2013 [ 45 ], one in 2014 [ 46 ], three in 2015 [ 47 , 48 , 49 ] and two in 2016 [ 50 , 51 ]. Most of the studies (61%) were performed exclusively by Brazilians Institution [ 16 , 18 , 20 , 21 , 22 , 24 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 37 , 41 , 42 , 43 ,…”

Section: Resultsmentioning

confidence: 99%

“…There was a predominance of studies that were performed in the State of Pará (47%) [ 22 , 23 , 25 , 26 , 27 , 29 , 35 , 36 , 37 , 38 , 39 , 40 , 42 , 43 , 45 , 47 , 48 ]. Some studies had been performed in the State of Amazonas (22%) [ 17 , 19 , 24 , 30 , 33 , 41 , 44 , 49 ], Rondônia (14%) [ 18 , 28 , 46 , 50 , 51 ], Mato Grosso (8%) [ 21 , 31 , 32 ] and Amapá (3%) [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Hair as a Biomarker of Long Term Mercury Exposure in Brazilian Amazon: A Systematic Review

Castro¹,

Lima

2018

IJERPH

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Many studies have assessed mercury (Hg) exposure in the Amazonian population. This article performs a literature search of the studies that used hair as a biomarker of Hg exposure in the Brazilian Amazonian population. The search covered the period from 1996 to 2016 and included articles which matched the following criteria: (1) articles related to Hg exposure into Brazilian Amazon; (2) articles that used hair as a biomarker of Hg exposure; (3) articles that used analytical tools to measure the Hg content on hair and (4) articles that presented arithmetic mean and/or minimum and maximum values of Hg. 36 studies were selected. The findings show that most of the studies were performed along margins of important rivers, such as Negro, Tapajós and Madeira. All the population presented mean levels of Hg on hair above 6 µg g−1 and general population, adults, not determined and men presented levels of Hg on hair above 10 µg g−1. The results show that most of the studies were performed by Brazilian institutions/researchers and the majority was performed in the State of Pará. The present study identified that Amazonian population has long-term been exposed to Hg. In terms of future perspectives, this study suggests the implementation of a strategic plan for environmental health surveillance in the region in order to promote health and benefit Amazonian population.

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“…GSTs are highly polymorphic in humans and an association between certain GST genotypes (e.g. GSTM1 * 0/GSTT1 * 0) and the retention of the metal has been established (Mazzaron Barcelos et al, 2012). Methylmercury undergoes enterohepatic cycling, and is thereby partly converted by the intestinal microflora to mercuric mercury, which is less effectively absorbed in the gut and therefore excreted via faeces.…”

Section: Excretionmentioning

confidence: 99%

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

2012

EFS2

403

160

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EFSA was asked by the European Commission to consider new developments regarding inorganic mercury and methylmercury toxicity and evaluate whether the Joint FAO/WHO Expert Committee on Food Additives (JECFA) provisional tolerable weekly intakes for methylmercury of 1.6 µg/kg body weight (b.w.) and of 4 µg/kg b.w. for inorganic mercury were still appropriate. In line with JECFA, the CONTAM Panel established a tolerable weekly intake (TWI) for inorganic mercury of 4 µg/kg b.w., expressed as mercury. For methylmercury, new developments in epidemiological studies from the Seychelles Child Developmental Study Nutrition Cohort have indicated that n-3 long-chain polyunsaturated fatty acids in fish may counteract negative effects from methylmercury exposure. Together with the information that beneficial nutrients in fish may have confounded previous adverse outcomes in child cohort studies from the Faroe Islands, the Panel established a TWI for methylmercury of 1.3 µg/kg b.w., expressed as mercury. The mean dietary exposure across age groups does not exceed the TWI for methylmercury, with the exception of toddlers and other children in some surveys. The 95 th percentile dietary exposure is close to or above the TWI for all age groups. High fish consumers, which might include pregnant women, may exceed the TWI by up to approximately six-fold. Unborn children constitute the most vulnerable group. Biomonitoring data from blood and hair indicate that methylmercury exposure is generally below the TWI in Europe, but higher levels are also observed. Exposure to methylmercury above the TWI is of concern. If measures to reduce methylmercury exposure are considered, the potential beneficial effects of fish consumption should also be taken into account. Dietary inorganic mercury exposure in Europe does not exceed the TWI, but inhalation exposure of elemental mercury from dental amalgam is likely to increase the internal inorganic mercury exposure; thus the TWI might be exceeded. This opinion focuses only on the risks related to dietary inorganic mercury and methylmercury exposure and does not assess the nutritional benefits linked to certain foods (e.g. fish and other seafood).A call for annual collection of chemical contaminant occurrence data in food and feed, including mercury, was issued by EFSA in December 2010. In response, EFSA received 59 820 results on mercury in food from 20 European countries, mainly covering the period from 2004 to 2011. A total number of 59 650 results were described with sufficient detail to be used in the statistical analysis of the respective food groups; 98.2 % of the samples were for total mercury, 1.8 % for methylmercury and three samples for inorganic mercury.All the 20 food groups available at the first level of FoodEx were covered in the current data collection. The food groups 'Fish and other seafood' and 'Meat and meat products' dominated the food product coverage with 36.8 % and 17.6 % respectively. These were followed by 'Grain and grain-based products' at 7.8 % and 'Vegetables an...

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Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Cited by 24 publications

References 50 publications

Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb

Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb

Hair as a Biomarker of Long Term Mercury Exposure in Brazilian Amazon: A Systematic Review

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

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