Interaction between glyphosate and mitochondrial succinate dehydrogenase

Ugarte, Ricardo

doi:10.1016/j.comptc.2014.05.018

Cited by 19 publications

(15 citation statements)

References 40 publications

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“…A decrease in succinate-dependent respiratory indexes of rat liver mitochondria is observed with 85 mg/L of glyphosate in Roundup (Peixoto, 2005). In fact, glyphosate interacts at the succinate binding site of mitochondrial succinate dehydrogenase (Ugarte, 2014). An electron microscopy analysis after Roundup hepatocyte exposure has shown a M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 8 reduced respiratory activity and a decreased transcriptional/splicing activity (Malatesta et al, 2008).…”

Section: Peer-reviewed Literaturementioning

confidence: 95%

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Potential toxic effects of glyphosate and its commercial formulations below regulatory limits

Mesnage¹,

Defarge²,

Vendômois³

et al. 2015

Food and Chemical Toxicology

426

276

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Glyphosate-based herbicides (GlyBH), including Roundup, are the most widely used pesticides worldwide. Their uses have increased exponentially since their introduction on the market. Residue levels in food or water, as well as human exposures, are escalating. We have reviewed the toxic effects of GlyBH measured below regulatory limits by evaluating the published literature and regulatory reports. We reveal a coherent body of evidence indicating that GlyBH could be toxic below the regulatory lowest observed adverse effect level for chronic toxic effects. It includes teratogenic, tumorigenic and hepatorenal effects. They could be explained by endocrine disruption and oxidative stress, causing metabolic alterations, depending on dose and exposure time. Some effects were detected in the range of the recommended acceptable daily intake. Toxic effects of commercial formulations can also be explained by GlyBH adjuvants, which have their own toxicity, but also enhance glyphosate toxicity. These challenge the assumption of safety of GlyBH at the levels at which they contaminate food and the environment, albeit these levels may fall below regulatory thresholds. Neurodevelopmental, reproductive, and transgenerational effects of GlyBH must be revisited, since a growing body of knowledge suggests the predominance of endocrine disrupting mechanisms caused by environmentally relevant levels of exposure.

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Section: Peer-reviewed Literaturementioning

confidence: 95%

“…Cancer progression may also be promoted at the mitochondrial level following succinate dehydrogenase inhibition that disturbed the epigenetic landscape (Cervera et al, 2009). Interestingly, glyphosate interacts at the succinate binding site of mitochondrial succinate dehydrogenase (Ugarte, 2014).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 98%

Potential toxic effects of glyphosate and its commercial formulations below regulatory limits

Mesnage¹,

Defarge²,

Vendômois³

et al. 2015

Food and Chemical Toxicology

426

276

View full text Add to dashboard Cite

show abstract

“…Cytotoxicity has also been detected by other biochemical markers e.g., mitochondrial functions, release of lactate dehydrogenase, cell proliferation determined by the use of sulforhodamine B, or membrane integrity and lysosomal activities indicated by the uptake of neutral red dye (Koller et al, 2012;Defarge et al, 2016). The interaction of between glyphosate and mitochondrial succinate dehydrogenase has been verified by molecular modeling (Ugarte, 2014). The IPA salt of glyphosate was indicated to be genotoxic at concentrations of 0.16-1.6 µg/ml on human lymphocytes, fish erythrocytes and plant staminal nuclei in vitro and in vivo (Alvarez-Moya et al, 2014).…”

Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 96%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

104

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“…Abdel-Mallek et al (1994) find that oxygen consumption in soil treated with glyphosate was significantly inhibited. Ugarte (2014) showed that glyphosate inhibits the activity of mitochondrial succinate dehydrogenase, a key enzyme that takes part in the Krebs cycle and electron transport chain.…”

Section: Glyphosate Treatments and Lichen Physiologymentioning

confidence: 99%