Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk

Palma, Selena; Novelli, Flavia; Padua, Luca; Venuti, Aldo; Prignano, G.; Mariani, Luciano; Cozzi, Renata; Tirindelli, Donatella; Testa, Antonella

doi:10.1007/s00432-009-0757-3

Cited by 26 publications

(26 citation statements)

References 62 publications

(51 reference statements)

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“…21 studies of GSTM1 polymorphisms (2,250 CC cases and 3,025 controls) [6,8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] , 17 studies of GSTT1 polymorphisms (1,704 CC cases and 2,060 controls) genotypes [6, 11-13, 15-17, 20-24, 26-30] , and 9 studies of GSTM1-GSTT1 interaction analyses (1,046 CC cases and 1,319 controls) [6,11,12,15,16,24,26,28] were included in our meta-analysis. The characteristics of the studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Liu¹,

Zeng²,

Ma³

et al. 2017

ijSciences

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Objective: To study the influence of GSTM1 and GSTT1 gene polymorphisms on cervical cancer (CC) risk, and explore genetic-environmental interactions. Methods: After a systematic literature search, all relevant studies entailing the association between GST polymorphisms and CC were included. The pooled odds ratio (OR) was used for analysis of the results and corresponding 95% confidence intervals (CI) were estimated. Results: A total of 23 case-control studies were included in the meta-analysis of GSTM1 (2,250 CC cases and 3,025 controls) and GSTT1 (1,704 CC cases and 2,460 controls) genotypes. For the GSTM1 polymorphisms, the null genotype of GSTM1 was associated with an increased CC risk for the total population (OR=1.57, 95% CI=1.25-1.98). A similar association was found in China (OR=2.34, 95% CI=1.56-3.52), India (OR=2.02, 95% CI=1.43-2.83), Pakistan (OR=5.52, 95% CI=2.34-13.07), Serbia (OR=1.73, 95% CI=0.68-4.39) and Kazakhstan (OR=6.5, 95%CI=2.25-18.81), but was not noted for others countries. Regarding human papilloma virus (HPV) infection, moderately but significantly increased risk of the null GSTM1 genotype was found in HPV-positive patients (OR=2.59, 95% CI=1.57-4.27). For the GSTT1 polymorphisms, the null GSTT1 genotype was associated with increased CC risk in the total population (OR=1.44, 95% CI=1.07-1.93). Regarding ethnic stratification, a significantly increased risk of the null GSTT1 genotype was found in Kazakhstan (OR=3.99, and Brazil (OR=4.58, 95% CI=2.04-10.28). With respect to smoking, the two aspects of the analysis above were not significantly associated with CC risk in smokers or non-smokers, respectively. For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk for the total population (OR=1.62, 95% CI=1.14-2.29). Conclusion: This meta-analysis provided sufficient evidence that the null genotype of GSTM1, or GSTT1 and the dual-null genotypes of GSTM1/GSTT1 are associated with CC.

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Section: Resultsmentioning

confidence: 99%

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Liu¹,

Zeng²,

Ma³

et al. 2017

ijSciences

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“…According to the exclusion criteria, 15 articles were excluded including 5 articles containing overlapping population [7][8][9][10][11], 8 precancerous lesions included in the cases [12][13][14][15][16][17][18][19], 2 without sufficient data [20][21]. At last, data were available from 16 individual case-control studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], Table 1 presented characteristics of these 16 case-control studies (a total of 1,627 CC cases and 2,161 controls). 14 studies on GSTM1 polymorphism (a total of 1,514 CC cases and 1,907 controls), 12 studies on GSTT1 polymorphism (a total of 1,187 CC cases and 1,590 controls), and 6 studies on GSTM1-GSTT1 interaction analysis (a total of 791 CC cases and 767controls) were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Compared with Economopoulos et al 's meta-analysis, our meta-analysis had some differences. Firstly, our meta-analysis included three new eligible studies published in Chinese [22][23][24] and two new case-control studies [25][26] in English in 2010, and excluded four studies [13,16,18,19] that had precancerous lesions patients in cases. Secondly, Asians (including Chinese, Indians, Koreans, Japanese and Thais), Caucasians and Latinos were stratified by ethnicity in our meta-analysis, while Chinese (including Koreans, Japanese and Thais) and non-Chinese were stratified GSTM1 AND GSTT1 POLYMORPHISMS AND CERVICAL CANCER RISK Fig.…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

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There were some studies on the associations between Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) polymorphisms and cervical cancer (CC) risk, but the results were inconsistent. Thus, a meta-analysis was performed.The electronic databases PubMed, Science Direct, CBM, and CNKI were searched for possible studies. Finally, 16 studies (1,627 cases and 2,161 controls) were included. For the GSTM1 and GSTT1 polymorphisms, the unadjusted odds ratios (OR) and 95% confidence intervals (95% CI) from each study were used to estimate summary OR. Subgroup analyses by ethnicity and histological type of CC were also performed.For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66). Similar association was found in Asians (OR=1.47, 95% CI=1.11-1.94), but not in Caucasians (OR=0.96, 95% CI=0.73-1.27). For the GSTT1 polymorphism, the null genotype of GSTT1 was not statistically significantly associated with CC risk in total population (OR=1.36, 95% CI=0.97-1.90). This result was also found in Asians (OR=1.27, 95% CI=0.87-1.85) and Caucasians (OR=1.09, 95% CI= 0.66-1.79), but not in Latinos (OR=4.58, 95% CI= 2.04-10.28). For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk in total population (OR=1.77, 95% CI= 1.14-2.75), and all the six studies were from Asia. For subgroup analyses by histological type of CC, the three aspects of the analyses above were all not significantly associated with CC risk in squamous cell carcinoma and adenocarcinoma, respectively.The null genotype of GSTM1 and the dual null genotypes of GSTM1/GSTT1 were risk factors in CC, and the null genotype of GSTT1 was not associated with CC risk.

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“…On the other hand, Sobti et al (2006) found among smokers, a 7-fold increased risk of developing cervical cancer in the absence of these genes. These variations found in different populations may be due to different lifestyles, diet, environmental factors and other genetic factors (Liu & Xu 2012), as well as more efficient metabolic and detoxifying activity of tobacco compounds in some individuals than in others (Palma et al 2010). GST enzymes participate in important route of detoxification through conjugation of glutathione to toxic compounds (drugs, carcinogens, α-β unsaturated lipid aldehydes, aryl halides, alkyl halides and nitroaromatic) (Rudd et al 2011, Kiyohara et al 2010.…”

Section: Characteristics Of Womenmentioning

confidence: 99%

“…Surprisely, GST metabolism seems to be related not only to chemical compounds, but genetic polymorphism of GST has been correlated with risk of developing cervical lesion (Liu & Xu 2012, Kiran et al 2010, Singh et al 2008, Sui et al 2011. The GST comprises a family of phase II enzymes, which act in metabolic detoxification of xenobiotic and endogenous reactive species (Palma et al 2010). In mammals, it is divided into three families: cytosolic, mitochondrial and microsomal.…”

Section: Introductionmentioning

confidence: 99%

Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

Soares¹,

Martins²,

Medeiros³

et al. 2013

VR&R

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Human papillomavirus (HPV) is responsible for developing cancers, among them cervical cancer, which is the second cancer responsible for female mortality. The polymorphism of glutathione S-transferase (GST) is closely linked to an increased risk of cervical lesions and HPV infection. This enzyme is involved in phase II of xenobiotic metabolism, which can eliminate potential toxic carcinogenic compounds from the body. In this study, it was analysed the association between GSTM1 and/or GSTT1 polymorphism and susceptibility to HPV infection or development of cervical lesions. It was also analysed the correlation of these polymorphisms with external factors such as number of sexual partners, parity, smoking and alcohol consumption. Women who had more than one sexual partner presented 2.35 times more chances of being infected by HPV, but it could not be associated to the development of cervical lesions. However, more than three pregnancies leads to high risk (OR=3.2) of developing cervical lesions. Considering the genotypes analyzed in this study, only GSTT1 null showed significant influence on the risk of HPV infection among consumers of alcohol (OR=6.6) and none of them showed influence on the risk of developing cervical lesions (P <0.05). The study of other polymorphisms and expression of GST isoforms and enzymes that act in phase I of xenobiotics metabolism, for example, could lead to further clarification of the effect of oxidative stress on cellular susceptibility to HPV infection, since the results this research point to this interaction.

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Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk

Abstract: We suggest that the investigation of multiple gene polymorphisms, versus single genes, could contribute to a better understanding of the effect of susceptibility genes on cancer risk.

Cited by 26 publications

References 62 publications

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Association Between Glutathione S-Transferase Genotypes, Human Papillomavirus Infection and Development of Cervical Injury in Olinda -Pe

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