Interaction between estrogen receptor and retinol-binding protein-4 polymorphisms as a tool for the selection of prolific pigs

Gonçalves, Iara Denise Vasconcellos; Gonçalves, Paulo Bayard Dias; Silva, Janandra Cortese da; Portela, Valério V.M.; Borges, Luiz Felipe Kruel; Oliveira, João Francisco Coelho de; Lovatto, Paulo Alberto

doi:10.1590/s1415-47572008000300014

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…Moreover, previous authors [ 1 , 9 ] concluded that the presence of B allele had a negative effect on the litter size, suggesting that A allele was in favor of prolificacy. In addition, Sun et al [ 21 ] reported that crossbreed pigs with the AA genotype produced 0.72 TNB, 0.64 NBA more than the BB genotypic sows, while Gonçalves et al [ 22 ] reported that A allele of RBP4 gene produced more piglets (TNB) and more live piglets per litter (NBA).…”

Section: Discussionmentioning

confidence: 99%

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Marantidis

Laliotis

Avdi

2016

Genetics Research International

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PCR-RFLP was applied to a commercial crossbred pig population in order to investigate the association between polymorphism (SNP) of Retinol-binding protein 4 (RBP4) gene and reproductive performance. 400 sows were genotyped and 2000 records of reproductive traits were used in order to retrieve information about the allele frequencies and the association of the RBP4 gene with main reproductive characteristics of the population. A deviation from the Hardy-Weinberg equilibrium was observed as a result of the AB genotype excess. In addition, the AA genotype saw statistically significant higher values of (i) the total number of born piglets (p < 0.05), (ii) the number of piglets born alive (p < 0.01), and (iii) the number of weaned piglets (p < 0.01). The number of the mummified piglets and the number of the piglets born dead did not differ between the various RBP4 genotypes. Interestingly, the AA genotype had a negative impact (p < 0.05) on the number of piglets born dead, resulting indirectly in a larger litter size. In conclusion, the AA genotype and in extension the A allele of RBP4 gene are in favor of producing larger litter size, suggesting that the RBP4 gene may be used in Marker-Assisted Selection (MAS) programs for a rapid improvement of the reproductive characteristics in pigs.

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Section: Discussionmentioning

confidence: 99%

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Marantidis

Laliotis

Avdi

2016

Genetics Research International

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“…The growing literature on relevant polymorphisms implicated in disease susceptibility may provide an alternative strategy for selection. For example, retinol-binding protein polymorphisms (Goncalves et al 2008) are associated with prolificacy in pigs, but effects on tissue concentrations are unknown.…”

Section: Geneticsmentioning

confidence: 99%

“…For example, retinol-binding protein polymorphisms (Goncalves et al . 2008) are associated with prolificacy in pigs, but effects on tissue concentrations are unknown.…”

Section: Geneticsmentioning

confidence: 99%

The potential for increasing the concentrations of micro-nutrients relevant to human nutrition in meat, milk and eggs

Rooke¹,

Flockhart²,

Sparks³

2010

J. Agric. Sci.

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SUMMARYA possible outcome of policies designed to reduce obesity in the human population and to mitigate greenhouse gas (GHG) emissions may be a decrease in human consumption of livestock products. However, livestock products currently make substantial contributions to intakes of specific micro-nutrients. Therefore, the present review examines the potential for increasing micro-nutrient concentrations of milk, muscle meats and eggs by nutritional and genetic means. Of the trace elements, copper (Cu), iron (Fe) and zinc (Zn) concentrations were largely resistant to manipulation by dietary means, but iodine (I) and selenium (Se) could be readily manipulated. Similarly, whileα-tocopherol concentrations were readily manipulated, responses to dietary supplementation with retinol, folate and cobalamin were lower and riboflavin was resistant to dietary manipulation. There were differences between products in the ease with which composition could be manipulated: egg concentrations were most responsive followed by milk and muscle meats. However, livestock products with increased micro-nutrients concentrations can supply a substantial proportion of the daily reference nutrient intake.

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“…Besides, a possible dependence on the genetic background should be taken into account, because epistatic effects could be affecting pig prolificacy as recently reported [ 38 , 39 ]. Gonçalves et al [ 14 ] have pointed out that effects of the RBP4-MspI polymorphism on litter size depend on the genotype of the ESR1 - Pvu II allele in a comparison between sows from three genotypic classes. The litter size for second and later parities of sows carrying either ESR1 allele A/ RBP4 genotype 11 or ESR1 allele B/ RBP4 genotype 22 was greater than that of sows grouped in the third class ( ESR1 AA/ RBP4 22 and ESR1 BB/ RBP4 11).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Gonçalves et al . [ 14 ] have performed an interesting study in a commercial population that revealed a significant interaction on litter size between RBP4 - Msp I and ESR1-PvuII polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line

Muñoz¹,

Fernández²,

Óvilo³

et al. 2010

Genet Sel Evol

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BackgroundThe aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-MspI and ESR1-PvuII polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated.MethodsDetection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-MspI and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early (NBA12) and later parities (NBA3+ ) as different traits. A joint analysis of RBP4-MspI and ESR1-PvuII was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered.ResultsFour different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-MspI and ESR1-PvuII polymorphisms of 0.61 ± 0.29 piglets was detected on NBA3+. The IGF2 analysis revealed a significant increase on NBA3+ of 0.74 ± 0.37 piglets for the paternally inherited allele A.ConclusionsAll the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-MspI and ESR1-PvuII polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes.

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Interaction between estrogen receptor and retinol-binding protein-4 polymorphisms as a tool for the selection of prolific pigs

Cited by 8 publications

References 20 publications

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

The potential for increasing the concentrations of micro-nutrients relevant to human nutrition in meat, milk and eggs

Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line

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