Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Marantidis, A.; Laliotis, George P.; Avdi, M.

doi:10.1155/2016/4940532

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…Contrary to our findings, Marantidis et al. (2016) reported that both AA and AB genotypes were favoured in producing higher values of TNB, NBA and number of weaned piglets (NW) traits (piglets/birth), rendering the A allele as an allele with an additive effect. There are many other studies (Messer et al., 1996; Ollivier et al., 1997; Spötter et al., 2009) that reported association of AA genotype with higher TNB, NBA and NW piglets/birth.…”

Section: Resultscontrasting

confidence: 99%

“…A similar pattern of B allele distribution has been reported in Large White and Landrace × Large White populations (Dall’Olio et al., 2010; Marantidis et al., 2016; Rothschild et al., 2000; Wang et al., 2006) and in Black Slavonian sows (Kabalin et al., 2013). Higher allelic values for A allele have been previously reported in Duroc (Drogemuller et al., 2001).…”

Section: Resultssupporting

confidence: 75%

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Evaluation of candidate genes related to litter traits in Indian pig breeds

Vashi

Magotra

Kalita

et al. 2021

Reprod Domestic Animals

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Improvement in litter traits is the key to profitable pig farming that directly enhances the economic standing of the farmers in developing countries. The present study aimed to explore oestrogen receptor (ESR), epidermal growth factor (EGF), follicle‐stimulating hormone beta subunit (FSHβ), prolactin receptor (PRLR) and retinol‐binding protein 4 (RBP4) genes as possible candidate genetic markers for litter traits in indigenous pigs of India. The breeds included in the study were Ghungroo, Mali, Niang Megha and Tenyi Vo, and the reproductive traits considered were litter size at birth (LSB), number born alive (NBA), litter weight at birth (LWB), litter size at weaning (LSW) and litter weight at weaning (LWW) at their first parity. PCR‐RFLP and primer‐based mutation detection methods were used to identify polymorphism, and associations between the genotypes and the traits were analysed using a general linear model. The Ghungroo pigs recorded the best litter performances among the breeds (p < .05, LWB p < .01). Different alleles and genotypes of the genes under study were detected. Short interspersed nuclear element (SINE) −/− genotype of FSHβ revealed significantly higher litter traits (p < .05, LSB p < .01). The LWW was also found to be significantly influenced by ESR BB and AB, EGF AB and BB, and PRLR CC genotypes (p < .05). Although we did not find statistically significant and consistently superior litter traits with respect to different genotypes of other studied genes than genotype SINE −/− of the FSHβ, PRLR CC genotype demonstrated superior performances for all the litter traits. Our study revealed the FSHβ as a potential candidate genetic marker for litter traits in indigenous pig breeds of India.

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Section: Resultscontrasting

confidence: 99%

Section: Resultssupporting

confidence: 75%

Evaluation of candidate genes related to litter traits in Indian pig breeds

Vashi

Magotra

Kalita

et al. 2021

Reprod Domestic Animals

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show abstract

“…Also, Drogemuller et al (2001) were not able to detect significant effects on litter size in a synthetic line for the RBP4 genotypes. Or in contrast, several other studies indicated that the AA genotype has higher TNB and NBA compared to the other genotypes (Rothschild et al, 2000;Omelka et al, 2008, Spotter et al, 2009Marantidis et al, 2015). Rothschild et al (2000) found an additive effect of allele A on TNB and NBA in several commercial lines, but no statistically significant effect of any allele on litter size in the synthetic line.…”

Section: Discussionmentioning

confidence: 90%

Additive Genetic Effects of RNF4, RBP4, and IGF2 Polymorphisms on Litter Size in Landrace and Yorkshire Sows

Nguyen

Duc

Nguyen

et al. 2019

vjas

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The association of the RNF4, RBP4, and IGF2 genotypes and their additive genetic effects with litter size in purebred Landrace and Yorkshire sows were studied. The results revealed significant associations between the RNF4 and RBP4 genotypes with the total number of piglets born (TNB) and number of piglets born alive (NBA) traits (P <0.05). The RNF4 CC genotype had greater TNB and NBA than the TT genotype in both breeds. The RBP4 BB genotype had greater TNB and NBA than the AA genotype in the Landrace breed. Significant additive effects of the RNF4 and RBP4 genes on the TNB and NBA were detected (P <0.05). No significant associations of the IGF2 genotypes and their additive effects with any reproductive traits were observed in both Landrace and Yorkshire sows (P >0.05). The results suggested that the RNF4 and RBP4 genes could be useful in selection for increasing TNB and NBA traits in pigs. KeywordsRNF4, RBP4, IGF2, additive genetic effect, litter size Nguyen Thi Vinh et al. (2019) https://vjas.vnua.edu.vn/ 315

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“…The roles of RBP4 in reproduction have been supported by accumulating studies. A recent study identified a new single nucleotide polymorphism in RBP4 affecting the production of large litter size of sows [13]. Studies have shown that RBP4 expresses in bovine ovarian cells [14], early vitellogenic oocytes of the trout ovary [15], and ovaries of zebrafish [16].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4

Zhao

Zhou

2019

Genes

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Retinol binding protein 4 (RBP4), mainly secreted by the liver and adipocytes, is a transporter of vitamin A. RBP4 has been shown to be involved in several pathophysiological processes, such as obesity, insulin resistance, and cardiovascular risk. Reports have indicated the high expression levels of RBP4 in cystic follicles. However, the role of RBP4 in mammalian follicular granulosa cells (GCs) remains largely unknown. To illustrate the molecular pathways associated with the effects of RBP4 on GCs, we used high-throughput sequencing to detect differential gene expression in GCs overexpressing RBP4. A total of 113 differentially expressed genes (DEGs) were identified in RBP4-overexpressing GCs, and they included 71 upregulated and 42 downregulated genes. The differential expressions of the top 10 DEGs were further confirmed by real-time quantitative polymerase chain reaction. Pathway analysis indicated that the DEGs are mostly involved in oxidative phosphorylation, Parkinson’s disease, non-alcoholic fatty liver disease, Huntington’s disease, cardiac muscle contraction, Alzheimer’s disease, fatty acid biosynthesis, AMP-activated protein kinase signaling pathway, and insulin signaling pathway. Genes in these pathways should be useful for future studies on GCs. Altogether, the results of our study establish a framework for understanding the potential functions of RBP4 in porcine GCs.

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Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Cited by 12 publications

References 24 publications

Evaluation of candidate genes related to litter traits in Indian pig breeds

Evaluation of candidate genes related to litter traits in Indian pig breeds

Additive Genetic Effects of RNF4, RBP4, and IGF2 Polymorphisms on Litter Size in Landrace and Yorkshire Sows

Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4

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