Interaction Between Cephalosporins and Alcohol

Portier, H.; Chalopin, Jean-Marc; Freysz, M.; Tanter, Y.

doi:10.1016/s0140-6736(80)90151-8

Cited by 49 publications

(14 citation statements)

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“…Recently, disulfiram like reactions were observed clinically in patients and in healthy volunteers who ingested ethanol after they had been given some newly developed 8-lactam antibiotics (4)(5)(6)(7)(8)(9)(10)(11)29). Subsequently, an increase of the blood acetaldehyde level was demonstrated in rats pretreated with the NMTT-containing (3-lactam antibiotics (9,12,13,30).…”

Section: Discussionmentioning

confidence: 99%

“…Effect of cefamandole (CMD) on alcohol metabolizing system in rats: Recently, some 9-lactam antibiotics were found to exhibit a disulfiram-like activity in alcohol me tabolism (4)(5)(6)(7)(8)(9)(10)(11). Thus, the in vivo effects of 3-lactam antibiotics on the alcohol metabolizing system in rats were investigated using CMD as a model of 9-lactam anti biotics.…”

Section: Subcellularmentioning

confidence: 99%

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A Comparative Study on the Effects of Disulfiram and β-Lactam Antibiotics on the Acetaldehyde-Metabolizing System in Rats

Matsubara

Otsubo

Ogawa

et al. 1986

Japanese Journal of Pharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Subcellularmentioning

confidence: 99%

A Comparative Study on the Effects of Disulfiram and β-Lactam Antibiotics on the Acetaldehyde-Metabolizing System in Rats

Matsubara

Otsubo

Ogawa

et al. 1986

Japanese Journal of Pharmacology

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“…The methylthiotetrazole group structurally resembles disulfiram and inhibits aldehyde dehydrogenase resulting in acetaldehyde accumulation. Disulfiram-like reactions have been reported in patients and normal healthy volunteers who have consumed alcohol after administration of cefoperazone [32][33][34], moxalactam [34][35][36][37], cefamandole [38,39] e cefotetan [40]. Recently, disulfiram-like reactions induced by cefuroxime, which do not contain the methylthiotetrazole side chain, was identified as the cause of sudden death [41].…”

Section: Disulfiram-like Reactions With Anti-infective Drugsmentioning

confidence: 99%

Alcohol-Medication Interactions: The Acetaldehyde Syndrome

Oliveira¹

2014

J Pharmacovigil

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Medications that inhibit aldehyde dehydrogenase when coadministered with alcohol produce accumulation of acetaldehyde. Acetaldehyde toxic effects are characterized by facial flushing, nausea, vomiting, tachycardia and hypotension, symptoms known as acetaldehyde syndrome, disulfiram-like reactions or antabuse effects. Severe and even fatal outcomes are reported. Besides the aversive drugs used in alcohol dependence disulfiram and cyanamide (carbimide), several other pharmaceutical agents are known to produce alcohol intolerance, such as certain anti-infectives, as cephalosporins, nitroimidazoles and furazolidone, dermatological preparations, as tacrolimus and pimecrolimus, as well as chlorpropamide and nilutamide. The reactions are also observed in some individuals after the simultaneous use of products containing alcohol and disulfiram-like reactions inducers. Depending on the pharmacological inducer, reactions may occur several days after treatment completion. Disulfiram-alcohol reaction includes moderate decrease in blood pressure, but severe life-threatening arterial hypotension and shock sometimes develop. Myocardial infarction secondary to disulfiram-alcohol reaction has been also reported. For severe hypotension resulting from a disulfiram-ethanol reaction, adrenaline or noradrenaline have been employed as the pressor agent of choice. Fomepizole, an alcohol dehydrogenase inhibitor, may be a safe and effective treatment of severe reactions. When medications that produce antabuse effects are prescribed or dispensed, patients should be instructed to avoid medicines and other products containing alcohol, such as syrups, fermented vinegar, sauces and lotions. It is essential that doctors, nurses and pharmacists instruct patients to avoid alcohol during treatment with aversive drugs and disulfiram-like reactions inducers. Likewise, even when scientific evidence is inconclusive, such instructions should be provided in leaflets, which are often the only source of information for patients and a guide for health professionals.

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“…Several beta-lactam antibiotics were found to show a reaction similar to that of disul firam, when patients pretreated with some beta-lactam antibiotics ingested an alcohol containing drink (1)(2)(3)(4)(5)(6)(7)(8)(9). Subsequently, several investigators demonstrated that pretreatment of rats with antibiotics having the N-methyl tetrazolylthiomethyl group at the 3-position of the cephalosporin nucleus causes an increase in blood acetaldehyde levels when ethanol is administered 1 day after the pre treatment (6,(10)(11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 99%

Pharmacokinetics of latamoxef and N-methyltetrazolethiol in rats associated with the development of disulfiram-like effects.

et al. 1987

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Abstract-The disulfiram-like effect of beta-lactam antibiotics, having an N methyltetrazolethiol (NMTT) as a 3'-position substituent of the cephalosporin nucleus, was determined in rats using latamoxef (LMOX) as a model. Intravenous and subcutaneous administrations of these antibiotics caused a decrease in the low Km aldehyde dehydrogenase (ALDH) activity in liver mitochondria and an increase in blood acetaldehyde level during ethanol metabolism, as in the case of disulfiram. When the antibiotic was administered intravenously to biliary fistula rats, the blood acetaldehyde level did not increase. On the other hand, oral administration of antibiotic to normal and biliary fistula rats caused pronounced development of disulfiram-like effects in both animals. When LMOX was injected to normal rats, the rapid and slow eliminations of LMOX and NMTT, respectively, were observed from blood and liver. After oral administration of LMOX, NMTT remained in the blood and liver for a long time with higher concentrations, although LMOX could not be detected in the body. With biliary fistula rats, intravenous injection of LMOX led to rapid urinary excretion of both LMOX and NMTT. These results indicate that the development of disulfiram-like effects of NMTT-containing antibiotics is closely related to the pharmacokinetic profile of NMTT released from its parent drugs.

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Interaction Between Cephalosporins and Alcohol

Cited by 49 publications

References 1 publication

A Comparative Study on the Effects of Disulfiram and β-Lactam Antibiotics on the Acetaldehyde-Metabolizing System in Rats

A Comparative Study on the Effects of Disulfiram and β-Lactam Antibiotics on the Acetaldehyde-Metabolizing System in Rats

Alcohol-Medication Interactions: The Acetaldehyde Syndrome

Pharmacokinetics of latamoxef and N-methyltetrazolethiol in rats associated with the development of disulfiram-like effects.

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