Interaction between carcinogenic and anti-carcinogenic trace elements in the scalp hair samples of different types of Pakistani female cancer patients

Wadhwa, Sham Kumar; Kazi, Tasneem Gul; Afridi, Hassan Imran; Talpur, Farah Naz; Naeemullah,

doi:10.1016/j.cca.2014.10.007

Cited by 44 publications

(25 citation statements)

References 64 publications

(73 reference statements)

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“…[8][9][10][11] Eleven casecontrol studies quantified either toenail, hair, blood or urinary arsenic species in breast cancer patients and controls. [12][13][14][15][16][17][18][19][20][21] Generally, the results show a weak or negative correlation with exceptions of reports by Wadhwa et al, and Joo et al, who found arsenic levels to be significantly higher in hair of breast cancer patients as compared to unaffected controls. 21,22 There have been no prospective studies that have examined blood arsenic levels and breast cancer risk.…”

Section: Introductionmentioning

confidence: 82%

“…Four ecological studies evaluated soil, water or rice contamination with arsenic and local breast cancer rates . Eleven case–control studies quantified either toenail, hair, blood or urinary arsenic species in breast cancer patients and controls . Generally, the results show a weak or negative correlation with exceptions of reports by Wadhwa et al ., and Joo et al ., who found arsenic levels to be significantly higher in hair of breast cancer patients as compared to unaffected controls .…”

Section: Introductionmentioning

confidence: 92%

“…[12][13][14][15][16][17][18][19][20][21] Generally, the results show a weak or negative correlation with exceptions of reports by Wadhwa et al, and Joo et al, who found arsenic levels to be significantly higher in hair of breast cancer patients as compared to unaffected controls. 21,22 There have been no prospective studies that have examined blood arsenic levels and breast cancer risk. However, there have been two prospective studies examining the impact of ambient arsenic on breast cancer risk, one prospective study comparing toenail arsenic concentrations pre and post breast cancer diagnosis and one study that used rice consumption as a proxy for arsenic exposure.…”

Section: Introductionmentioning

confidence: 94%

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Blood arsenic levels and the risk of familial breast cancer in Poland

Marciniak

Derkacz

Muszyńska

et al. 2019

Intl Journal of Cancer

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Arsenic is recognized as a potent carcinogen at high concentrations, but the relationship between environmental arsenic and breast cancer risk has not well been studied. Most research has focused on the effect of arsenic in populations with high endemic exposure, and not in populations with arsenic levels within normal limits. We sought to determine if blood arsenic levels predict the risk of breast and other cancers risk among women in northern Poland. The cohort consisted of 1,702 healthy women, aged 40 and above, identified between 2010 and 2017. Blood arsenic level was determined by inductively coupled plasma mass spectrometry. After an average of 4.5 years of follow‐up (range 0.7–7.3 years), there were 110 incident cases of cancer diagnosed in the cohort, including 68 cases of breast cancer. Women in the highest quartile of arsenic had a highly significant 13‐fold increased risk of developing breast cancer, compared to women in the lowest quartile (hazard ratio [HR] = 13.2; 95% confidence interval [CI] 4.02–43.0). Results were similar for arsenic and all incident cancers (HR quartile 4 vs. quartile 1 = 13.3; 95% CI 4.78–37.0). If confirmed, our study suggests that the blood arsenic level may be a useful predictive marker of cancer risk in women.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 94%

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Blood arsenic levels and the risk of familial breast cancer in Poland

Marciniak

Derkacz

Muszyńska

et al. 2019

Intl Journal of Cancer

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“…Environmental contamination by heavy metals has been reported to cause BC (41)(42)(43)(44)(45)(46)(47)(48)(49). As, Cd, and Ni have been classified as Group 1 human carcinogens by the World Health Organization (50). Furthermore, Pb, Hg, and Cr have been classified as human and animal carcinogens or co-carcinogens (27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of heavy metals and metabolites in the urine of patients with breast cancer

Men

Zhang

et al. 2019

Oncol Lett

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Epidemiologic studies demonstrated that the environment serves a crucial role in cancer development. Heavy metals, including arsenic (As), cadmium (cd), chromium (Cr), lead and mercury, are considered to be carcinogens or co-carcinogens. Furthermore, Cd has been detected in breast cancer (BC) tissue at high concentrations. The present study aimed to investigate the correlation between heavy metals detected in urine and urine metabolome of patients with BC, and their association with cancer development. Nuclear magnetic resonance was used to determine urine metabolites and an inductively coupled plasma mass spectrometry system was used to detect heavy metals in urine samples. The results demonstrated that Cd was markedly increased in the urine of patients with BC compared with the control population (approximately 2-fold). Cr and As were also increased in the urine of patients with BC. In addition, numerous small molecule metabolites were altered in the urine of patients with BC compared with the control population. This study also demonstrated that alterations in small molecule metabolites in the urine of patients with BC were very similar to results from a previous report. These findings indicated that environmental exposure to Cd, As, or Cr could influence the urine levels of metabolites, which may be involved in BC development. Further investigation is therefore required to examine a larger range of samples from different countries or areas in order to understand the impact of heavy metals on metabolism and BC development.

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“…Regarding ovarian cancer specifically, results have also been mixed. Epidemiologic studies of selenium from food and supplements (15)(16)(17)(18), serum (19,20), hair (21), and toenails (14) have shown both null and inverse associations. We discerned no clear pattern among those studies that might reconcile the disparate findings based on methodologic or study design features.…”

Section: Discussionmentioning

confidence: 99%