Interaction between Antipyrine and the Microsomal Ethanol Oxidation in Rat Liver

Abstract

The kinetics of hepatic microsomal ethanol oxidation (MEOS) was studied in microsomal suspension from rat liver. The estimated maximum elimination rate was 117 nmol acetaldehyde/ min/g liver and the half-saturation concentration 12.7 mmol ethanol/l. The MEOS activity was not influenced by the presence of antipyrine 0.1 mmol/l and 1.0 mmol/l in the microsomal incubations.