Age dependence of rat liver function measurements

Fischer‐Nielsen, Anne; Poulsen, Henrik E.; Hansen, Bent Adel; Tygstrup, Niels; Keiding, Susanne

doi:10.1016/0168-8278(89)90050-0

Journal of Hepatology

1989

DOI: 10.1016/0168-8278(89)90050-0

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Age dependence of rat liver function measurements

Anne Fischer‐Nielsen

Henrik E. Poulsen

Bent Adel Hansen

et al.

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Cited by 8 publications

(1 citation statement)

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“…The ability of the liver to produce urea in response to protein ingestion, an essential hepatic process ( 5 ) , appears to be impaired in ageing man (6), but the process has never been studied during ageing under standardized conditions of substrate availability. Studies of urea cycle enzymes in experimental animals did not show any age-related defect (7,8), and a study demonstrated an increase in mitochondrial carbamoyl-phosphate synthetase (9), which is in agreement with the increased capacity for urea synthesis demonstrated in older rats (10).…”

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confidence: 58%

Kinetics of hepatic amino‐nitrogen conversion in ageing man

Fabbri

Marchesini

Bianchi

et al. 1994

Liver

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Previous studies have shown that hepatic function, quantitatively measured by dynamic liver function tests, progressively declines with ageing. Urea synthesis is a specific process taking place in the liver; a reduced urea synthesis in response to a protein‐rich metal has previously been demonstrated in the elderly, but the process has never been standardized in relation to amino acid supply. We measured the hepatic conversion of α‐amino nitrogen into urea nitrogen in response to alanine infusion in 32 subjects, with normal routine liver and renal function tests and without evidence of previous hepatic disorders, belonging to three different age‐groups (≤55 years, 56–70, ≥71). The functional hepatic nitrogen clearance was reduced on average by 20% in subjects aged 56–70 years, and by 30% in subjects over 70 years old in comparison to the age‐group under 55 years (ANOVA: P=0.0001), and significantly correlated with age (r=‐0.684). No sex differences were observed on the effects of age on hepatic clearance. Also, liver volume, measured by ultrasonography, was reduced with advancing age, but the age‐related decrease in hepatic nitrogen conversion was not primarily dependent on decreased liver volume. The measurement of functional hepatic nitrogen clearance has already been validated as a quantitative liver function test in clinical hepatology. In keeping with previous studies, the age‐related deceline in hepatic nitrogen conversion points to a decreased functional capacity of the ageing hepatic parenchyma.

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mentioning

confidence: 58%

Kinetics of hepatic amino‐nitrogen conversion in ageing man

Fabbri

Marchesini

Bianchi

et al. 1994

Liver

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Comparison of α2-Macroglobulin Synthesis by Juvenile vs. Mature Rats after Identical Inflammatory Stimulation

et al. 2013

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Synthesis of α2-macoglobulin (α2M) by 3-week-old juvenile rats was compared to that of mature 7- and 11-week-old rats. Serum concentrations of α2M, interleukin (IL)-6- and cytokine-induced neutrophil chemoattractant (CINC)-1 were measured by enzyme-linked immunosorbent assay. The area under the concentration vs. time curve (AUC) for α2M was significantly different among the three groups. The synthesis of α2M increased in an age-dependent manner. No significant difference was observed for the AUC of IL-6, but that of CINC-1 in 3-week-old rats was significantly lower than that in 7- or 11-week-old rats. These results suggest that synthesis of α2M was increased in mature compared to juvenile rats, possibly due to differences in liver function. The maximum concentration of CINC-1 in 3-week-old rats was observed 6 h after turpentine oil injection. The serum concentrations of IL-6 and CINC-1 increased more quickly in juvenile rats than in mature rats after inflammatory stimulation.

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Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats

Kawase

Kondoh

Matsumoto

et al. 1995

Mechanisms of Ageing and Development

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Age dependence of rat liver function measurements

Cited by 8 publications

References 18 publications

Kinetics of hepatic amino‐nitrogen conversion in ageing man

Kinetics of hepatic amino‐nitrogen conversion in ageing man

Comparison of α2-Macroglobulin Synthesis by Juvenile vs. Mature Rats after Identical Inflammatory Stimulation

Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats

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