Interaction between Adiponectin and Aldosterone

Flynn, Colleen; Bakris, George L.

doi:10.1159/000327023

Cited by 30 publications

(23 citation statements)

References 59 publications

(44 reference statements)

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“…It has been shown that aldosterone affects adiponectin and resistin secretion by adipose tissue [47][48][49]. Moreover, it is well known that progesterone is a natural antagonist of the mineralocorticoid receptor.…”

Section: Discussionmentioning

confidence: 99%

The gender- and fat depot-specific regulation of leptin, resistin and adiponectin genes expression by progesterone in rat

Stelmańska

Kmieć

Świerczyński

2012

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionmentioning

confidence: 99%

The gender- and fat depot-specific regulation of leptin, resistin and adiponectin genes expression by progesterone in rat

Stelmańska

Kmieć

Świerczyński

2012

The Journal of Steroid Biochemistry and Molecular Biology

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“…It normally serves to reduce the expression of pro-inflammatory factors such as IL-6 and also affords anti-lipogenic protection to the cardiomyocyte mediated by AMPK (105). In addition, adiponectin may also be involved in aldosterone signaling in conditions of insulin resistance and diabetic heart disease (25). …”

Section: Development and Progression Of Cardiac Dysfunction As A Resumentioning

confidence: 99%

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes

et al. 2013

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Diabetes mellitus type 2 (T2DM) is a widespread chronic medical condition with prevalence bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is more common in patients with diabetes than the non-diabetic population. While hypertensive and ischemic heart disease is more common in diabetic patients, there is another type of heart disease in diabetes that is not associated with hypertension or coronary artery disease. This muscle functional disorder is termed “diabetic cardiomyopathy”. Diastolic dysfunction characterized by impaired diastolic relaxation time and reduced contractility precedes systolic dysfunction and is the main pathogenic hallmark of this condition. Even though the pathogenesis of “diabetic cardiomyopathy” is still controversial, impaired cardiac insulin sensitivity and metabolic overload are emerging as major molecular and metabolic mechanisms for cardiac dysfunction. Systemic insulin resistance, hyperinsulinemia, dysregulation of adipokine secretion, increases in circulating levels of inflammatory mediators, aberrant activation of renin angiotensin aldosterone system (RAAS), and increased oxidative stress contribute dysregulated insulin and metabolic signaling in the heart and development of diastolic dysfunction. In addition, maladaptive calcium homeostasis and endothelial cell dysregulation endoplasmic reticular stress play a potential role in cardiomyocyte fibrosis/diastolic dysfunction. In this review, we will focus on emerging molecular and metabolic pathways underlying cardiac dysfunction in diabetes. Elucidation of these mechanisms should provide a better understanding of the various cardiac abnormalities associated with diastolic dysfunction and its progression to systolic dysfunction and heart failure.

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“…8 Adiponectin levels are inversely related to aldosterone (and sympathetic activity) levels. 9 Adipocytes and FFA Elevated FFA levels and uptake play an integral part in adipocyte physiology. They trigger increased pro-inflammatory expression via pathways that involve Toll-like receptor 4, nuclear factor kappa B (NF-jB), as well as several other mechanisms.…”

Section: A Primer On the Adipocytementioning

confidence: 99%