Interaction between a variant of CDKN2A/B-gene with lifestyle factors in determining dyslipidemia and estimated cardiovascular risk: A step toward personalized nutrition

Mehramiz, Mehrane; Ghasemi, Faeze; Esmaily, Habibollah; Tayefi, Maryam; Hassanian, Seyed Mahdi; Sadeghzade, Mahsa; Sadabadi, Fatemeh; Moohebati, Mohsen; Azarpazhooh, Mahmoud Reza; Parizadeh, Seyed Mohammad Reza; Heidari‐Bakavoli, Alireza; Safarian, Mohammad; Nematy, Mohsen; Ebrahimi, Mahmoud; Ryzhikov, Mikhail; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.1016/j.clnu.2016.12.018

Cited by 30 publications

(34 citation statements)

References 57 publications

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“…In another study of our group, the associations of two SNPs; rs1333049 and rs10811661 located in CDKN2A/B loci were assessed with clinical features of individuals with esophageal squamous cell carcinoma. This analysis showed patients with CC genotype of ANRIL rs1333049 polymorphism were related with lower OS of patients with esophageal squamous cell carcinoma (ESCC) (Ghobadi, Mehramiz & Anvari, 2017), which is in line with several other studies of our group on this locus in metabolic syndrome and CVD (Mehramiz et al, 2016;Tajbakhsh et al, 2016). In another two studies on CDKN2A/B rs1011970, the minor allele (T) was related to an increased risk of breast cancer and presented as a prognostic marker (Antoniou et al, 2012).…”

Section: Cdkn2a/b Genes Encode Tumor Suppressors P15 Ink4b and P16supporting

confidence: 89%

Association of cyclin‐dependent kinase inhibitor 2A/B with increased risk of developing breast cancer

Seifi

Pouya

Rahmani

et al. 2019

Journal Cellular Physiology

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There is a growing body of data reporting the association of genetic alterations in chromosome 9P21 with the risk of developing cancer. In the current study, we studied the association of a genetic variant in CDKN2A/B, rs1333049, with the risk of developing breast cancer. A total of 339 participants with and without breast cancer entered to the study. Genotyping was done by the TaqMan real‐time polymerase chain reaction (RT‐PCR) method and gene expression analysis was ran by RT‐PCR. Our data showed that the minor allele homozygote in the total population was 10%, whereas for heterozygote was 38%. The dominant genetic model demonstrated that individuals with breast cancer had advanced TNM classification. Moreover, the logistic regression revealed that individuals who had CC/CG genotypes might have an enhanced risk of developing breast cancer when compared to the holders of GG genotype (e.g., OR = 2.8; 95% CI,1.4–5.4; p = .001), after regulated for confounders; age and body mass index. Furthermore, our analysis showed that the CDKN2A/B gene was downregulated in patients (p < .001). We showed a meaningful relationship of CDKN2A/B with the risk of breast cancer, cancer, showing the importance of studies in great sample size and several centers for studying the value of the marker as a risk classification in the management of patients with breast cancer.

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Section: Cdkn2a/b Genes Encode Tumor Suppressors P15 Ink4b and P16supporting

confidence: 89%

Association of cyclin‐dependent kinase inhibitor 2A/B with increased risk of developing breast cancer

Seifi

Pouya

Rahmani

et al. 2019

Journal Cellular Physiology

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“…In a meta-analysis study by Liu, the results showed that the association of TNF-308 G>A polymorphism with cervical cancer in the Asian population was significantly higher. [17][18][19][20][21][22][23][24][25] Our findings showed that TNF-308 G>A was associated with an increased risk of developing cervical cancer, supporting further investigations in a larger population and multi-center setting to reveal the prognostic value of the marker as a risk stratification biomarker in cervical cancer. 12 Another study showed that allele TNFa-308A induces an increase in TNF-a induction and its expression.…”

Section: Discussionsupporting

confidence: 59%

Association of TNF‐308 G>A polymorphism located in tumor necrosis factor a with the risk of developing cervical cancer and results of pap smear

Babapour

Mehramiz

Moghadam

et al. 2018

J of Cellular Biochemistry

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Tumor necrosis factor a (TNFa) is an inflammatory cytokine that plays a crucial role in the immune response and the progression of cervical lesions. There is a growing body of data evaluating the value of a genetic variant in the TNFa gene with the risk of developing cervical cancer. The aim of this study was to explore the association of a variant, TNF‐308 G>A, residing in the TNFa gene with cervical cancer. A total of 91 women with cervical cancer and 161 women as the control group were recruited. DNA was extracted, and Taqman®‐probes‐based assay was used for genotyping. Our results showed that the minor allele frequency was 0.3 in total population, and the frequency of minor allele A was more in the case group compared with the control. The regression models in different genetic models also revealed that the allele A is a potential risk factor for the development of cervical cancer. In particular, in the dominant model, patients with AG and AA genotypes had a higher risk of developing cervical cancer with odds ratio (OR) of 2.75 (95% confidence interval [CI]: 1.57‐4.83, <0.001) and OR of 7.27 (95%CI: 2.5‐20.8, <0.001), compared with the GG genotype. Moreover, a similar outcome was obtained for smear test results. Our study demonstrated that TNF‐308 G>A located on TNF‐a was associated with the risk of cervical cancer, supporting further studies in a larger population and multicenter setting to show the value of emerging markers as risk stratification biomarkers in cervical cancer.

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“…Hematological indices including white blood cells count (WBC), red blood cells count (RBC), platelet counts (PLT), hemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), red blood cell distribution width (RDW), and platelet distribution width (PDW) were measured using a Sysmex K800 automated cell counter (Sysmex Inc. United States), as described recently .…”

Section: Methodsmentioning

confidence: 99%

Relationship between platelet count and platelet width distribution and serum uric acid concentrations in patients with untreated essential hypertension

et al. 2018

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Interaction between a variant of CDKN2A/B-gene with lifestyle factors in determining dyslipidemia and estimated cardiovascular risk: A step toward personalized nutrition

Cited by 30 publications

References 57 publications

Association of cyclin‐dependent kinase inhibitor 2A/B with increased risk of developing breast cancer

Association of cyclin‐dependent kinase inhibitor 2A/B with increased risk of developing breast cancer

Association of TNF‐308 G>A polymorphism located in tumor necrosis factor a with the risk of developing cervical cancer and results of pap smear

Relationship between platelet count and platelet width distribution and serum uric acid concentrations in patients with untreated essential hypertension

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