Tumor necrosis factor a (TNFa) is an inflammatory cytokine that plays a crucial role in the immune response and the progression of cervical lesions. There is a growing body of data evaluating the value of a genetic variant in the TNFa gene with the risk of developing cervical cancer. The aim of this study was to explore the association of a variant, TNF‐308 G>A, residing in the TNFa gene with cervical cancer. A total of 91 women with cervical cancer and 161 women as the control group were recruited. DNA was extracted, and Taqman®‐probes‐based assay was used for genotyping. Our results showed that the minor allele frequency was 0.3 in total population, and the frequency of minor allele A was more in the case group compared with the control. The regression models in different genetic models also revealed that the allele A is a potential risk factor for the development of cervical cancer. In particular, in the dominant model, patients with AG and AA genotypes had a higher risk of developing cervical cancer with odds ratio (OR) of 2.75 (95% confidence interval [CI]: 1.57‐4.83, <0.001) and OR of 7.27 (95%CI: 2.5‐20.8, <0.001), compared with the GG genotype. Moreover, a similar outcome was obtained for smear test results. Our study demonstrated that TNF‐308 G>A located on TNF‐a was associated with the risk of cervical cancer, supporting further studies in a larger population and multicenter setting to show the value of emerging markers as risk stratification biomarkers in cervical cancer.
Introduction: Isolated metastasis of cervical carcinoma to iliopsoas region might be infrequent and its occurrence is a diagnostic challenge. The aim of this study was to report on a case of iliopsoas muscle metastasis from cervical carcinoma. Case Presentation: A 52-year-old multiparous females complaining about post menopause bleeding was referred to the researcher's oncology department. Gynecological examination revealed cervical mass with involved parameters and biopsy confirming squamous cell carcinoma. In addition, the patient had a large cystic mass on the lateral side of pelvic area and abdomen. Investigations detected solid ovarian mass associated with a rise of tumor marker CA-125 and CEA levels. Magnetic resonance imaging (MRI) and CT scan reports suggested possible hematoma in iliopsoas muscle. Imaging-guided biopsy detected metastatic squamous cell carcinoma in iliopsoas muscle mass. Based on diagnosis of advance stage cervical cancer, the patient received chemotherapy following adjuvant radiation therapy. Conclusions: Metastasis of squamous cell carcinoma of the cervix to iliopsoas muscle is considered as a rare event. It is recommended to keep this unusual manifestation in mind.
Introduction: Uterine arteriovenous malformation (AVM) following molar pregnancy is a rare condition. The present study aimed at reporting a case of uterine arteriovenous malformation after molar pregnancy. Case Presentation: A 38-year-old woman with repeated heavy vaginal bleeding was referred to oncology department of Ghaem hospital affiliated to Mashhad University of Medical Sciences in 2016. She had history of evacuation curettage of molar pregnancy in the previous month. Examinations revealed AVM in fundus of uterus; and the patients was asymptomatic after embolization of the AVM and she is now under serial follow-up.
Conclusions:The diagnosis of AVM should be considered when an unexplained massive hemorrhage occurs after gestational trophoblastic disease. In the case of correct diagnosis, unnecessary surgery is avoided.
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