Interacting noradrenergic and corticosteroid systems shift human brain activation patterns during encoding

Stegeren, Anda H. van; Roozendaal, Benno; Kindt, Merel; Wolf, Oliver T.; Joëls, Marian

doi:10.1016/j.nlm.2009.08.004

Cited by 122 publications

(104 citation statements)

References 75 publications

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“…However, and most importantly, the present findings indicate that such a glucocorticoid/norepinephrine-induced disruption of mPFC functioning induces not only impairment of working memory but also enhancement of long-term memory consolidation. Findings of a recent functional imaging study in human subjects are consistent with this view and indicate that the combined administration of glucocorticoid and noradrenergic agonists during the encoding of emotionally arousing material induces a strong deactivation of the PFC and that the level of deactivation correlates positively with enhanced performance on a retention test given 1 wk later (41). It should be emphasized, however, that the consequences of glucocorticoid (or norepinephrine) administration and PKA activation on cellular physiology within the mPFC, especially during task performance, are far from clear (42).…”

Section: Discussionsupporting

confidence: 56%

Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

Barsegyan

Mackenzie

Kurose

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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234

169

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It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effects on these two memory functions have generally been considered to be independently regulated processes. Here we report that a glucocorticoid receptor agonist administered into the medial prefrontal cortex (mPFC) of male Sprague-Dawley rats both enhances memory consolidation and impairs working memory. Both memory effects are mediated by activation of a membrane-bound steroid receptor and depend on noradrenergic activity within the mPFC to increase levels of cAMPdependent protein kinase. These findings provide direct evidence that glucocorticoid effects on both memory consolidation and working memory share a common neural influence within the mPFC.

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Section: Discussionsupporting

confidence: 56%

Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

Barsegyan

Mackenzie

Kurose

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

234

169

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“…Together, the beneficial effects of the fMRI setup on memory performance for all scenes might have masked the more subtle effects of poststimulus arousal. Moreover, when NA levels are elevated in addition to cortisol, there is no additive effect on memory performance (van Stegeren et al, 2010;Kukolja et al, 2011). Contrary to the neutral stimuli in the current study, the memory for emotional stimuli is enhanced in fMRI settings as well.…”

Section: Behavioral Performancecontrasting

confidence: 59%

Event-Related Nociceptive Arousal Enhances Memory Consolidation for Neutral Scenes

Schwarze

Bingel²,

Sommer³

2012

J. Neurosci.

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The superior memory for emotional events has been attributed to the beneficial effects of noradrenaline released into the amygdala attributable to arousal. Noradrenaline mediates the effects of different hormones and neurotransmitters, including adrenal stress hormones on consolidation ( Recently, it was highlighted that emotional stimuli elicit not only arousal but also intensify cognitive processes that contribute to the enhanced memory. In particular, the enhanced use of selective attention as well as the greater distinctiveness and semantic relatedness of emotional stimuli influence memory formation (Talmi et al., 2007a). The present study aimed to explore the effects of arousal on memory formation independent of these cognitive factors in an event-related manner. Arousal was induced by the application of a nociceptive stimulus briefly after the presentation of neutral scenes. The results show a purely arousal-driven memory enhancement for the neutral scenes that differs in critical aspects from the superior memory for emotional stimuli. In particular, the enhancement was only evident after consolidation and exclusively based on an increase in item familiarity but not recollection. Moreover, successful memory formation for stimuli followed by arousal was correlated with activity in the parahippocampal cortex but not the amygdala, as is the case for emotional stimuli.

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“…We used a double-blind, placebocontrolled between-subjects design in which participants were randomly assigned to one of four experimental conditions: (1) oral placebo (7 men, 8 women; plac); (2) oral placebo and hydrocortisone (20 mg, Jenapharm) (8 men, 7 women; placϩcort); (3) oral placebo and yohimbine (20 mg, Desma), a blocker of the ␣2 adrenergic receptor that stimulates central noradrenergic activity (9 men, 9 women; placϩyoh); (4) oral hydrocortisone and yohimbine (10 men, 9 women; Cortϩyoh). Drug doses were chosen in accordance with earlier studies (Buchanan and Lovallo, 2001;van Stegeren et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Concurrent Glucocorticoid and Noradrenergic Activity Shifts Instrumental Behavior from Goal-Directed to Habitual Control

Schwabe¹,

Tegenthoff²,

Höffken³

et al. 2010

Journal of Neuroscience

140

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Stress modulates instrumental action in favor of habitual stimulus-response processes that are insensitive to changes in outcome value and at the expense of goal-directed action-outcome processes. The neuroendocrine mechanism underlying this phenomenon is unknown. Here, we tested the hypothesis that concurrent glucocorticoid and noradrenergic activity bias instrumental behavior toward habitual performance. To this end, healthy men and women received hydrocortisone, the ␣2-adrenoceptor antagonist yohimbine or both orally before they were trained in two instrumental actions leading to two distinct food outcomes. After training, one of the outcomes was devalued by inviting participants to eat that food to satiety. A subsequent extinction test revealed whether instrumental performance was goal-directed or habitual. Participants that received hydrocortisone or yohimbine alone decreased responding to the devalued action in the extinction test, i.e., they behaved goal-directed. The combined administration of hydrocortisone and yohimbine, however, rendered participants' behavior insensitive to changes in the value of the goal (i.e., habitual). These findings demonstrate that the concerted action of glucocorticoids and noradrenergic activity shifts instrumental behavior from goal-directed to habitual control.

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Interacting noradrenergic and corticosteroid systems shift human brain activation patterns during encoding

Cited by 122 publications

References 75 publications

Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

Event-Related Nociceptive Arousal Enhances Memory Consolidation for Neutral Scenes

Concurrent Glucocorticoid and Noradrenergic Activity Shifts Instrumental Behavior from Goal-Directed to Habitual Control

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