Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

Barsegyan, Areg; Mackenzie, Scott M.; Kurose, Brian D.; McGaugh, James L.; Roozendaal, Benno

doi:10.1073/pnas.1011975107

Cited by 234 publications

(188 citation statements)

References 49 publications

(76 reference statements)

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“…These results suggest that the infralimbic cortex could contribute to the formation of aversive memory, in part, by increasing corticosterone concentrations. The involvement of corticosterone increases, immediately after training, enhancing the formation of aversive memory has been previously reported [36,37].…”

Section: Discussionmentioning

confidence: 53%

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Ronzoni

Antón

Mora

et al. 2016

Behavioural Brain Research

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2 HIGHLIGHTS-Infralimbic stimulation increases basal plasma levels of corticosterone.-Environmental enrichment enhances the effects of infralimbic stimulation.-Infralimbic inhibition reduces stress-induced corticosterone in control animals.-Infralimbic cortex contributes to HPA activation during stress and aversive memory. 3 ABSTRACTThe aim of the present study was to investigate the effects of the stimulation and inhibition of the ventral part of the medial prefrontal cortex (infralimbic cortex) on basal and stress-induced plasma levels of corticosterone and on the acquisition of aversive memory in animals maintained in control and environmental enrichment (EE) conditions. Intracortical microinjections of the GABA A antagonist picrotoxin and agonist muscimol were performed in male Wistar rats to stimulate and inhibit, respectively, the activity of the infralimbic cortex. Injections were performed 60 min before foot shock stress and training in the inhibitory avoidance task. Picrotoxin injections into the infralimbic cortex increased basal plasma levels of corticosterone.These increases were higher in EE rats which suggest that EE enhances the control exerted by infralimbic cortex over the hypothalamus-pituitary-adrenal (HPA) axis and corticosterone release. Muscimol injections into the infralimbic cortex reduced the stress-induced plasma levels of corticosterone and the retention latency 24 h after training in the inhibitory avoidance performance in control and EE animals, respectively. These results further suggest that the infralimbic cortex is required for the activation of the HPA axis during stress and for the acquisition of contextual aversive memories.

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Section: Discussionmentioning

confidence: 53%

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Ronzoni

Antón

Mora

et al. 2016

Behavioural Brain Research

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“…PFC function is enhanced under low to moderate acute stress (Yuen et al, 2009). Under high stress, norepinephrine levels and dopamine levels rise and shut down the PFC (Arnsten, 2000;Barsegyan, Mackenzie, Kurose, McGaugh, & Roozendaal, 2010;Birnbaum, Podell, & Arnsten, 2000;Roozendaal, McReynolds, McGaugh, 2004). There appears to be a narrow range for optimal norepinephrine (Aston-Jones & Cohen, 2005) and dopamine activity in the PFC (Arnsten & Goldman-Rakic, 1998;Murphy, Arnsten, Goldman-Rakic, & Roth, 1996;Zahrt, Taylor, Mathew, &Arnsten, 1997).…”

Section: Effects Of Stress On Memory-related Brain Regionsmentioning

confidence: 99%

“…Memory consolidation via the hippocampus is left relatively intact, to encode stressful events as a survival mechanism (Barsegyan, Mackenzie, Kurose, McGaugh, & Roozendaal, 2010;Liang, 2001;Roozendaal, McReynolds, McGaugh, 2004). As a consequence of this ability to better remember aversive events, our ability to retrieve and modulate information under stress may suffer.…”

Section: Effects Of Stress On Memory-related Brain Regionsmentioning

confidence: 99%

Effects of psychosocial stress on episodic memory updating

et al. 2013

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“…Animal studies showed that corticosterone and norepinephrine (NE) act together to facilitate memory formation through actions involving the amygdala, hippocampus, and prefrontal cortex (PFC) [10,12]. More recently, glucocorticoids and the noradrenergic system were shown to interact in the medial PFC in producing working memory impairment [13]. In addition, the capability of these systems to influence learning processes depending on other brain systems -such as the dorsal striatum -was also shown [14].…”

Section: Stress Mediators: Glucocorticoids and Norepinephrinementioning

confidence: 99%

Neural mechanisms and computations underlying stress effects on learning and memory

Luksys

Sandi

2011

Current Opinion in Neurobiology

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Stress has complex effects on memory function that can vary depending on the type of information that is learned and in relation to inter-individual characteristics. Recent work has also shown that stress can switch performance between memory systems, biasing it toward habit in detriment of spatial or goaldirected strategies. In addition, novel synaptic mechanisms have been implicated in the effects of stress in plasticity and memory. Computational modeling is emerging as a useful approach to integrate and to ascertain neural and cognitive computations underlying different effects of stress in memory. Having provided novel explanations for the inverted-U-shaped relationship between stress and cognitive performance, modelbased analysis studies can improve our understanding of diverse effects of stress in cognition and psychopathology. IntroductionStress can have profound effects on memory function, both when chronically experienced and when acutely coupled with a cognitive challenge [1]. In this review, we mainly focus on the effects of acute stress on learning, memory, and underlying mechanisms. We will also examine new modeling approaches aiming to ascertain the neural computations that underlie stress effects in these cognitive processes.It is generally accepted that acute stress or elevated stress hormones facilitate memory consolidation while impairing the retrieval of information [2]. Moreover, acute stress is generally highly disruptive for working memory processing, while it can facilitate implicit learning [1,2,3 ]. Recently, several animal and human studies showed that stress switches performance between memory systems, promoting a transition from 'flexible' spatial or goaldirected learning to 'rigid' habitual stimulus-response (S-R) cognitive strategies [4 ,5 ,6,7].However, one should be cautious when summarizing the effects of stress on a particular memory process as either positive or negative. Stress is not a unitary process, with its duration, intensity, or timing with regards to the cognitive challenge being critical for its cognitive outcome [1]. In particular, stress intensity has been long recognized in the literature as highly relevant, with the predominant belief that an inverted-U-shaped function can explain the relationship between stress intensity and memory (i.e. low and high stress levels impairing memory, whereas intermediate levels facilitating it). Strikingly, despite the popularity of this hypothesis, experimental evidence supporting the existence of an inverted-U-shaped relationship for performance of rats in a hippocampal learning task under the same experimental conditions was presented only recently [8]. Stress mediators: glucocorticoids and norepinephrineGlucocorticoids and the noradrenergic system have been identified as key mediators of the cognitive effects of stress [1,2,9,10]. Adrenal glucocorticoids, steroid hormones produced by the adrenal glands, can cross the blood-brain barrier, gaining access to the brain. Through the binding to specific receptors, glucocorticoids ca...

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Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

Cited by 234 publications

References 49 publications

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Effects of psychosocial stress on episodic memory updating

Neural mechanisms and computations underlying stress effects on learning and memory

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