Effects of psychosocial stress on episodic memory updating

Dongaonkar, Bhaktee; Hupbach, Almut; Gómez, Rebecca L.; Nadel, Lynn

doi:10.1007/s00213-013-2998-8

Cited by 24 publications

(25 citation statements)

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“…In a familiar context, the organism can bring its past experience in the context to bear on upcoming decisions and actions. Violations of predictions formed from past experiences in the context could lead to the formation of an entirely new context representation, or alternatively, the new information could be accommodated within an already existing context map—these phenomena are currently being studied under the rubric of ‘memory reconsolidation’ 14 , ‘memory updating’ 15–18 , and ‘integrative encoding’ 19 . In other words, hippocampal context representations can stimulate exploratory behavior, inform decisions from past experience, or rapidly update our understanding of the current state of the world.…”

Section: What Is the Global Function Of The Hippocampus And How Does mentioning

confidence: 99%

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

et al. 2017

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The hippocampus serves a critical function in memory, navigation, and cognition. Nature Neuroscience asked John Lisman to lead a group of researchers in a dialog on shared and distinct viewpoints on the hippocampus. There has been a long history of studying the hippocampus, but recent work has made it possible to study the cellular and network basis of defined operations—operations that include cognitive processes that have been otherwise difficult to study (see Box 1 for useful terminology). These operations deal with the context-dependent representation of complex memories, the role of mental exploration based on imagined rather than real movements, and the use of recalled information for navigation and decision-making. The progress that has been made in understanding the hippocampus has motivated the study of other brain regions that provide hippocampal input or receive hippocampal output; the hippocampus is thus serving as a nucleating point for the larger goal of understanding the neural codes that allow inter-regional communication and more generally, understanding how memory-guided behavior is achieved by large scale integration of brain regions. In generating a discussion among experts in the study of the cognitive processes of the hippocampus, the editors and I have posed questions that probe important principles of hippocampal function. We hope that the resulting discussion will make clear to readers the progress that has been made, while also identifying issues where consensus has not yet been achieved and that should be pursued in future research. – John Lisman

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Section: What Is the Global Function Of The Hippocampus And How Does mentioning

confidence: 99%

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

et al. 2017

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“…To study the reconsolidation hypothesis in human episodic memory, a similar procedure was designed, also based on learning interfering information after reactivation of a previously learned memory (Hupbach et al 2007). This procedure was used in a subsequent series of studies and was adapted by others to further characterize reconsolidation in episodic memory (Hupbach et al 2008(Hupbach et al , 2009(Hupbach et al , 2011Wichert et al 2011Wichert et al , 2013aJones et al 2012Jones et al , 2015Potts and Shanks 2012;Dongaonkar et al 2013;Gershman et al 2013;Wichert et al 2013b;Hupbach 2015).…”

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confidence: 99%

Intrusions in episodic memory: reconsolidation or interference?

2017

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It would be profoundly important if reconsolidation research in animals and other memory domains generalized to human episodic memory. A 3-d-list-discrimination procedure, based on free recall of objects, with a contextual reminder cue (the testing room), has been thought to demonstrate reconsolidation of human episodic memory (as noted in a previous study). Our goal was to replicate the central result, a high intrusion rate during recall of the target list, and evaluate the reconsolidation account relative to an alternative account, based on state-dependent learning and interference. First, replication was not straightforward (Experiment 1). Second, using a very unique, highly salient context (Experiment 2), the method produced a qualitative replication, but it was small in magnitude. A critical assumption of the reconsolidation account, that the target list is reactivated and destabilized during re-exposure to the study context, was not supported (Experiment 3). Although troubling for the reconsolidation account, the findings can be easily accommodated by an alternative account that does not assume additional neurobiological processes underlying the destabilization of consolidated memories, instead explaining intrusion rates simply in terms of well-established cognitive effects, such as item-to-context binding and interference during retrieval.

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“…Mild stressors or reminders of negative emotional events just following memory recall improve reconsolidation of emotional or neutral declarative learning tasks (Bos et al 2014b; Coccoz et al 2011; Finn and Roediger 2011). Additionally, post-reactivation, but not pre-reactivation psychosocial stress can enhance episodic memory (Dongaonkar et al 2013). …”

Section: Reconsolidation In Healthy Participantsmentioning

confidence: 99%

Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments

Dunbar

Taylor

2017

Neurobiology of Learning and Memory

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Interfering with memory reconsolidation has valuable potential to be used as a treatment for maladaptive memories and psychiatric disorders. Numerous studies suggest that reconsolidation-based therapies may benefit psychiatric populations, but much remains unanswered. After reviewing the literature in clinical and healthy human populations, we discuss some of the major limitations to reconsolidation studies and clinical application. Finally, we provide recommendations for developing improved reconsolidation-based treatments, namely exploiting known boundary conditions and focusing on a novel unconditioned stimulus-retrieval paradigm.

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Effects of psychosocial stress on episodic memory updating

Cited by 24 publications

References 82 publications

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

Intrusions in episodic memory: reconsolidation or interference?

Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments

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