Interacción entre farmacoterapia hipotensiva y terapia con ejercicio físico requiere regulación farmacológica en pacientes hipertensos

Effect of High-Intensity Interval Training on Body Composition, Cardiorespiratory Fitness, Blood Pressure, and Substrate Utilization During Exercise Among Prehypertensive and Hypertensive Patients With Excessive Adiposity

“…In addition to the results presented here, we have previously reported significant decreases in blood pressure and changes in the initial diagnoses of baseline hypertension or prehypertension patients (Cano-Montoya et al, 2016;Álvarez et al, 2018), but our present study is the first to report both blood pressure changes (as a change in clinical diagnosis), exercise substrate metabolism and cardiorespiratory fitness improvements in a hypertensive cohort. These finding demonstrate that HIIT could be considered an effective therapy against hypertension.…”

“…There is growing evidence to suggest that high-intensity interval training [HIIT, defined as several, brief bouts of high-intensity efforts, usually via cycling/running, interspersed with recovery periods (Gibala et al, 2012)], promote similar adaptations, and in a time-efficient way than to continuous, moderate-intensity training for improving cardiorespiratory fitness (Costa et al, 2018), but with little advantage for improving vascular function (Ramos et al, 2015;Pedralli et al, 2020). Thus, HIIT might have protective effects against the development of HTN (Pescatello et al, 2015;Álvarez et al, 2018), and can lead to the reversal of a clinical diagnosis of HTN to prehypertension [PreHTN], or from PreHTN to normotension, in a relevant proportion of patients (Cano-Montoya et al, 2016;Álvarez et al, 2018). These beneficial cardioprotective effects have been more reported for long-term (i.e., >12 weeks) rather than short-term exercise programs (Jurio-Iriarte and Maldonado-Martín, 2019).…”

Prevalence of Non-responders for Glucose Control Markers after 10 Weeks of High-Intensity Interval Training in Adult Women with Higher and Lower Insulin Resistance

“…Similarly, exercise-based interventions, including resistance training (RT), together with pharmacological, and dietary interventions, represent the cornerstones of T2DM management (ADA, 2011). In addition to the beneficial effects on glycemic control (Umpierre et al, 2013) and other risk factors of T2DM (Chudyk and Petrella, 2011; Figueira et al, 2014), physical exercise is effective in improving muscle strength (Dunstan et al, 2002), cardiovascular function (Cano-Montoya et al, 2016), and functional capacity (Cadore and Izquierdo, 2015). In this regard, combining RT and endurance training is an effective intervention to promote overall physical fitness in T2DM patients (Balducci et al, 2012).…”

Ejercicio intermitente y consejería nutricional mejoran control glicémico y calidad de vida en pacientes con diabetes mellitus tipo 2

“…Otros estudios han reportado, en el mismo tiempo, incluso una reducción de -6 cm en este marcador bajo solo régimen de ejercicio HIIT 27 . Por otra parte, posterior a la finalización del estudio fue necesaria una reevaluación de los pacientes en su farmacoterapia, siendo necesaria una 'regulación' de las dosis de fármacos en algunos de los pacientes del grupo GE, en las unidades de metformina, glibenclamida, insulina protamina neutra, de Hagedorn, atorvastatina, e hidroclorotiazida (datos no mostrados), de acorde a como previamente se ha reportado 14 . En estudios previos, Cade y cols., después de 12 semanas de ejercicio caminando 2 millas/día, suspendieron la farmacoterapia de 24 pacientes con hipertensión arterial quienes disminuyeron su presión sistólica en -22 y diastólica en -18 mmHg 28 .…”