Inter-relationships among psychopathology, cognition, and real-life functioning in early and late phase schizophrenia: A network analysis approach

Brasso, Claudio; Bellino, Silvio; Bozzatello, Paola; Favero, Elisa Del; Montemagni, Cristiana; Rocca, Paola

doi:10.1016/j.schres.2023.04.011

Cited by 6 publications

(5 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Findings from the present study indicate that associations of clinical manifestation with functional capacity are similar at various stages of schizophrenia with important roles of positive, negative and depressive symptoms as well as neurocognitive impairments. This observation is in agreement with results of the prior study showing no significant differences in the network of factors related to social functioning between early- and late-stage schizophrenia [ 27 ]. Also, the network comparison of remitted and non-remitted individuals with schizophrenia has demonstrated that depressive, positive, and negative symptoms are linked in a stable way [ 40 ].…”

Section: Discussionsupporting

confidence: 93%

“…For instance, Galderisi et al [ 26 ] found that improving functional capacity and daily life skills might be critical for planning any therapeutic interventions. Another study investigated differential effects of interrelationships between psychopathology, metacognition, and neurocognition on functional capacity in people with early- and late-stage of schizophrenia [ 27 ]. The authors found that the global network structure and strength do not differ significantly between both stages of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: insights from a network analysis

Misiak,

Piotrowski,

Samochowiec

2023

BMC Psychiatry

View full text Add to dashboard Cite

Background It has been shown that various aspects of clinical manifestation of schizophrenia are strongly related to social functioning. However, it remains unknown as to whether similar factors predict social functioning at various stages of psychosis. Therefore, the present study aimed to compare the effects of interconnections between various domains of psychopathology and neurocognition on social functioning in people during acute phase of psychosis and those during remission of positive and disorganization symptoms using a network analysis. Methods Two independent samples of individuals with schizophrenia spectrum disorders were enrolled (89 inpatients during acute phase and 90 outpatients during remission of positive and disorganization symptoms). Clinical assessment covered the levels of functioning, positive, negative and depressive symptoms. Cognition was recorded using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Data were analyzed by means of the network analysis. Two separate networks of clinical symptoms, social functioning, and cognition (i.e., in patients during acute phase of psychosis and remitted outpatients with schizophrenia) were analyzed and compared with respect to the measures of centrality (betweenness, closeness, strength, and expected influence) and edge weights. Results In both networks, the majority of centrality metrics (expected influence, strength, and closeness) had the highest values for the RBANS scores of attention (the sum of scores from two tasks, i.e., digit span and coding) and immediate memory. In both networks, social functioning was directly connected to positive, negative and depressive symptoms as well as the RBANS scores of attention and language. Additionally, in remitted patients, social functioning was directly connected to the RBANS score of immediate memory. Conclusions Findings from the present study indicate the central role of cognitive deficits, especially those related to attention, processing speed, working and immediate memory in shaping functional impairments regardless of schizophrenia phase. Therapeutic interventions that aim to improve functional capacity need to target these domains of neurocognitive performance.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: insights from a network analysis

Misiak,

Piotrowski,

Samochowiec

2023

BMC Psychiatry

View full text Add to dashboard Cite

show abstract

“…We chose to focus on CD because it has been correlated more than other aspects with NC dysfunction (51) and because it resembles Bleuler's concept of "loosening of associations, " i.e., the central mechanism underlying disturbances in thinking, motivation, and affective expression. However, our results obviously replicate the findings of the previous study of our group (32), which found that disorganization and visual learning not only exhibited high centrality indices, but seemed to be consistent with a metaanalysis (23) reporting that disorganization was associated with all NC domains. Generally, individuals with NC impairments express a more disorganized speech, making it difficult for listeners to discern the essential information needed to bind the speaker's ideas.…”

Section: Discussionsupporting

confidence: 92%

“…A recent study from our group ( 32 ) using a network analysis to explore the relative centrality and inter-relationships between symptoms, NC, SC, MC, and real-world functioning in early and late phase SZ revealed two key findings: first, disorganized symptoms considered as a whole are a critical piece connecting NC symptoms and MC exclusively in the late-SZ group (duration of illness >5 years); second, in the whole sample, regardless of illness duration, visual learning connected NC domains with disorganization, avolition, and MC.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Conceptual disorganization as a mediating variable between visual learning and metacognition in schizophrenia

Montemagni,

Brasso,

Bellino

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

ObjectivesThe aim of this study was to evaluate the relative contributions of visual learning and conceptual disorganization to specific metacognitive domains in a sample of outpatients with stable schizophrenia.MethodsA total of 92 consecutive outpatients with stable schizophrenia were recruited in a cross-sectional study. We analyzed the data with five path analyses based on multiple regressions to analyze the specific effect of visual learning on metacognitive capacity and metacognitive domains and the possible mediating role of conceptual disorganization.ResultsWe found that (i) visual learning was negatively correlated to metacognitive capacity and its domains on the one hand and conceptual disorganization on the other hand; (ii) conceptual disorganization was negatively associated with metacognition and its domains; and (iii) when the mediation effect was considered, conceptual disorganization fully mediated the relationship between visual learning and mastery, whereas it served as a partial mediator of the effect of visual learning on the other metacognition domains, i.e., self-reflectivity, understanding others’ mind, and decentration.ConclusionThese results delineate an articulated panorama of relations between different dimensions of metacognition, visual learning, and conceptual disorganization. Therefore, studies unable to distinguish between different components of metacognition fail to bring out the possibly varying links between neurocognition, disorganization, and metacognition.

show abstract

Impact of psychopathology on day-to-day living in patients with schizophrenia: A network analysis

Redlich Bossy,

Müller,

Niedermoser

et al. 2024

Comprehensive Psychiatry

View full text Add to dashboard Cite

Inter-relationships among psychopathology, cognition, and real-life functioning in early and late phase schizophrenia: A network analysis approach

Cited by 6 publications

References 60 publications

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: insights from a network analysis

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: insights from a network analysis

Conceptual disorganization as a mediating variable between visual learning and metacognition in schizophrenia

Impact of psychopathology on day-to-day living in patients with schizophrenia: A network analysis

Contact Info

Product

Resources

About