Intensive-care-unit-acquired bloodstream infections in a regional critically ill population

Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

“…Many changes have occurred in the epidemiology of BSI in recent years, particularly with the emergence of drug-resistant organisms, which has increased the treatment-failure rate and the risk of adverse patient outcomes [2,6]. Although hospital-acquired infections in critically ill patients have been the focus of numerous reports worldwide [2][3][4][5][6][7][8], there is a paucity of contemporary multinational data on the epidemiology and outcome determinants of HA-BSIs in ICU patients [2,4,9].…”

“…Results: We included 1,156 patients [mean ± standard deviation (SD) age, 59.5 ± 17.7 years; 65 % males; mean ± SD Simplified Acute Physiology Score (SAPS) II score, 50 ± 17] with HA-BSIs, of which 76 % were ICU-acquired. Median time to diagnosis was 14 [interquartile range (IQR), [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] days after hospital admission. Polymicrobial infections accounted for 12 % of cases.…”

Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients: A 1-year, large, prospective surveillance study in 5 Italian hospitals

“…These conditions have been estimated to complicate between 1.2% and 6.7% of all ICU admissions, with a high case mortality rate of >40% in different studies. 1,2 Globally, nearly 70% of the BSIs in ICUs are secondary to another primary infection (eg, central line, urinary or respiratory tract infections), whereas the remaining BSIs are of unknown origin. 3,4 A recent Italian study conducted in 125 ICUs reported that BSIs, particularly catheter related-BSIs, are the second most frequent ICU-acquired infection, with an incidence of 1.9 cases per 1,000 central venous catheter days.…”

Increase in catheter associated urinary tract infections in intensive care units at a tertiary care centre: a cause of concern

“…The NHSN data also shows E.coli as the major pathogen, accounting for 26.8% of the total isolates [14]. Laupland et al [18] also demonstrated E.coli as the most common etiological agent followed by Candida spp. E.coli has the capacity to adapt and survive in urinary tract by producing several virulence factors.…”