Intensity of continuous renal replacement therapy for acute kidney injury

Fayad, Alicia; Buamscha, Daniel; Ciapponi, Agustín

doi:10.1002/14651858.cd010613.pub2

Cited by 58 publications

(46 citation statements)

References 87 publications

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“…For example, previous studies have shown that, amongst general critically ill patients, diffusion and convection modes have similar capacity for clearance of small molecules (e.g., urea, creatinine, ammonia, glutamine) [26]. Furthermore, high (≥35mL/kg/h) and low (<35mL/kg/h) dose of renal replacement have been reported to have similar effect on mortality and renal function recovery [27]. Even if in specific subgroups of patients, these technical aspects may apply differently, the conclusions of such studies help to strengthen the validity of our results [28].…”

Section: Discussionmentioning

confidence: 99%

Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure

et al. 2017

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“…8 In parallel with these epidemiologic trends, various modifications in methodologic approaches have been developed, optimizing the intensity or timing of CRRT to improve survival. [9][10][11] Morbidity and mortality rates are still extremely high in this subset of patients, despite appropriate CRRT. 6,[12][13][14] Accordingly, precise assessment and monitoring of patient status is essential to improve overall outcomes.…”

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confidence: 99%

Development of a new mortality scoring system for acute kidney injury with continuous renal replacement therapy

et al. 2019

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Aim On the basis of the worst outcomes of patients undergoing continuous renal replacement therapy (CRRT) in intensive care unit, previously developed mortality prediction model, Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) and the Sequential Organ Failure Assessment (SOFA) needs to be modified. Methods A total of 828 patients who underwent CRRT were recruited. Mortality prediction model was developed for the prediction of death within 7 days after starting the CRRT. Based on regression analysis, modified scores were assigned to each variable which were originally used in the APACHE II and SOFA scoring models. Additionally, a new abbreviated Mortality Scoring system for AKI with CRRT (MOSAIC) was developed after stepwise selection analysis. Results We used all the variables included in the APACHE II and SOFA scoring models. The prediction powers indicated by C‐statistics were 0.686 and 0.683 for 7‐day mortality by the APACHE II and SOFA systems, respectively. After modification of these models, the prediction powers increased up to 0.752 for the APACHE II and 0.724 for the SOFA systems. Using multivariate analysis, seven significant variables were selected in the MOSAIC model wherein its C‐statistic value was 0.772. These models also showed good performance with 0.720, 0.734 and 0.773 of C‐statistics in the modified APACHE II, modified SOFA and MOSAIC scoring models in the external validation cohort (n = 497). Conclusion The modified APACHE II/SOFA and newly developed MOSAIC models could be more useful tool for predicting mortality for patients receiving CRRT.

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“…Dosing of various medicines, including antibiotics, must be adjusted to renal function levels. Continuous hemodiafiltration should be considered when laboratory data suggest hyperkalemia or metabolic acidosis, or when pulmonary edema results from excessive volume [35]. Patients with severely impaired renal function should receive perioperative HD.…”

Section: Resultsmentioning

confidence: 99%

Recommendations for perioperative management of lung cancer patients with comorbidities

Tsubochi

Shibano

Endo

2017

Gen Thorac Cardiovasc Surg

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ObjectivesTo improve surgical outcomes, clinicians must provide optimal perioperative care for comorbidities identified as significant factors in risk models for patients undergoing lung cancer surgery.MethodsWe reviewed trends in perioperative care for idiopathic pulmonary fibrosis, cardiovascular diseases, and end-stage renal diseases in patients undergoing lung cancer surgery, as large clinical databases indicate that these comorbidities are significant risk factors for lung cancer surgery. Articles identified by keyword searches were included in the analysis.ResultsSignificant predictive factors for acute exacerbation of idiopathic pulmonary fibrosis were identified. However, no effective perioperative care was identified for prevention of acute exacerbation of interstitial pneumonia. The timing of coronary revascularization and antithrombotic management for cardiovascular diseases are subjects of ongoing research, and acid–base balance is essential in the management of hemodialysis patients with end-stage renal diseases.ConclusionsTo improve surgical outcomes for lung cancer patients, future studies should continue to study optimal perioperative management of comorbidities.

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Intensity of continuous renal replacement therapy for acute kidney injury

Cited by 58 publications

References 87 publications

Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure

Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure

Development of a new mortality scoring system for acute kidney injury with continuous renal replacement therapy

Recommendations for perioperative management of lung cancer patients with comorbidities

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