Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: The Memorial Sloan-Kettering Cancer Center experience

Arruda, Fernando Freire de; Puri, Dev R.; Zhung, J.; Narayana, Ashwatha; Wolden, Suzanne L.; Hunt, Margie; Stambuk, Hilda E.; Pfister, David G.; Kraus, Dennis H.; Shaha, Ashok R.; Shah, Jatin P.; Lee, Nancy Y.

doi:10.1016/j.ijrobp.2005.03.006

Cited by 280 publications

(194 citation statements)

References 33 publications

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“…In all reported cases, it seems that careful selection and delineation of the targets resulted in very few or no marginal or out-of-field recurrences. de Arruda and colleagues reported that all recurrences in their series were in-field [45]. Chao and colleagues reported that most marginal recurrences occurred in the lower neck, which was treated with an anterior field that was matched to the IMRT-treated upper neck [11].…”

Section: Imrt For Oropharyngeal Carcinomamentioning

confidence: 99%

“…These factors make any attempt to compare the results of different IMRT series, or even series of IMRT with series of conventional RT, futile. Notwithstanding these limitations, all series of IMRT outcome have reported outstanding locoregional control rates for oropharyngeal cancer [11,12,[43][44][45]. These series reported 2-year locoregional tumor control rates of 90%-98% for patient populations consisting mainly of stage III-IV tumors.…”

Section: Imrt For Oropharyngeal Carcinomamentioning

confidence: 99%

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Intensity-Modulated Radiation Therapy for Head and Neck Carcinoma

et al. 2007

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After completing this course, the reader will be able to:1. Outline innovations related to targeted radiation therapy.2. Describe trials proving an advantage using IMRT.3. Assess treatment planning modalities and how IMRT fields are designed.4. Evaluate when there is a toxicity advantage for IMRT.5. Discern when conventional radiotherapy should be used instead of IMRT.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACT Intensity-modulated radiation therapy (IMRT) for head and neck tumors refers to a new approach that aims at increasing the radiation dose gradient between the target tissues and the surrounding normal tissues at risk, thus offering the prospect of increasing the locoregional control probability while decreasing the complication rate. As a prerequisite, IMRT requires a proper selection and delineation of target volumes. For the latter, recent data indicate the potential of functional imaging to complement anatomic imaging modalities. Nonrandomized clinical series in paranasal sinuses and pharyngolaryngeal carcinoma have shown that IMRT was able to achieve a very high rate of locoregional control with less morbidity, such as dry-eye syndrome, xerostomia, and swallowing dysfunction. The promising results of IMRT are likely to be achieved when many treatment conditions are met, for example, optimal selection and delineation of the target volumes and organs at risk, appropriate physical quality control of the irradiation, and accurate patient setup with the use of onboard imaging. Because of the complexity of the various tasks, it is thus likely that these conditions will only be

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Section: Imrt For Oropharyngeal Carcinomamentioning

confidence: 99%

Section: Imrt For Oropharyngeal Carcinomamentioning

confidence: 99%

Intensity-Modulated Radiation Therapy for Head and Neck Carcinoma

et al. 2007

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“…Limited data exist on the combination of concurrent chemotherapy with IMRT. In one study from MSKCC, patients with oropharynx cancer who were treated with chemoradiotherapy and IMRT showed no greater incidence of mucosal toxicity or strictures as compared with historical series of chemoradiotherapy [22]. However, in that study, chemotherapy was primarily bolus cisplatin, and the question of whether or not any additional toxicity will occur with multiagent chemotherapy and/or induction chemotherapy remains to be seen.…”

Section: Integration With Chemotherapymentioning

confidence: 93%

Commentary: IMRT for Head and Neck Cancer: Many Chapters Left to Write

Allen

Tishler

2007

The Oncologist

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“…Important clinical results have been published demonstrating high local control rates and preserved parotid function at the same time [52,53]. Several authors have contributed with data to establish a dose-volume dependency of the parotid.…”

Section: Dry Mouthmentioning

confidence: 99%

Measuring side effects after radiotherapy for pharynx cancer

Jensen

2007

Acta Oncologica

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Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: The Memorial Sloan-Kettering Cancer Center experience

Cited by 280 publications

References 33 publications

Intensity-Modulated Radiation Therapy for Head and Neck Carcinoma

Intensity-Modulated Radiation Therapy for Head and Neck Carcinoma

Commentary: IMRT for Head and Neck Cancer: Many Chapters Left to Write

Measuring side effects after radiotherapy for pharynx cancer

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