“…The radiation-induced toxicities were endurable. Recent studies have demonstrated that target volume coverage and critical organ protection were significantly improved with intensity-modulated radiotherapy (IMRT) compared with 3D-CRT in head-and-neck malignant tumor (13,14). It is reasonable for us to hypothesize that the higher dose could be given to involved regions and that OS might be improved by IMRT.…”
“…The radiation-induced toxicities were endurable. Recent studies have demonstrated that target volume coverage and critical organ protection were significantly improved with intensity-modulated radiotherapy (IMRT) compared with 3D-CRT in head-and-neck malignant tumor (13,14). It is reasonable for us to hypothesize that the higher dose could be given to involved regions and that OS might be improved by IMRT.…”
“…When concurrent chemoradiation is used, there is further variation over the choice of optimum fractionation schedule. IMRT, with its potential for Simultaneous Integrated Boost (SIB), further adds to this uncertainty [1] such that there is an increasing lack of uniformity of practice with no single 'standard of care'.…”
This variability in IMRT fractionation makes any meaningful comparison of treatment results difficult. Some standardization is needed particularly for design of multi-centre randomized clinical trials.
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