Intelligent hydrogel with both redox and thermo-response based on cellulose nanofiber for controlled drug delivery

Zong, Shiyu; Wen, Hankang; Lv, Hui; Li, Tong; Tang, Ruilin; Liu, Liujun; Jiang, Jianxin; Wang, Shengpeng; Duan, Jiufang

doi:10.1016/j.carbpol.2021.118943

Cited by 55 publications

(17 citation statements)

References 56 publications

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“…Nanofibers can be modified by varying parameters such as the concentration of polymer solution and drug, adjusting porosity ( Goyal et al, 2016 ), morphology and the diameter of fibers. Moreover, they can be functionalized to modulate the drug release ( Zong et al, 2022 ). They can provide sustained-release profile that results in a reduction in the frequency of administration and thus enhance patient compliance ( Gelb et al, 2022 ).…”

Section: Application Of Nanotechnology For Ocular Drug Deliverymentioning

confidence: 99%

Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

et al. 2022

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Section: Application Of Nanotechnology For Ocular Drug Deliverymentioning

confidence: 99%

Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

et al. 2022

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“…Hydrogels 20–30 nm in size (“nanogels”) are capable of incorporating hydrophobic drugs into the core and delivering them to their destination, providing their prolonged release. In particular, hydrogel delivery systems for enzymes [ 6 ], proteins [ 7 ], antibiotics [ 8 , 9 , 10 , 11 ], adenoviruses [ 12 ], anticancer drugs, for example, doxorubicin [ 13 , 14 , 15 ], paclitaxel [ 16 ], 5-fluorouracil [ 17 , 18 , 19 ], kaempferol [ 20 ], vincristine [ 21 ], oxaliplatin [ 22 ], cyclophosphamide [ 23 ], carmustine and curcumin [ 24 ], drugs for the treatment of skin diseases [ 25 , 26 , 27 ], anesthetics for the treatment of acute postoperative pain [ 28 ], antimicrobial silver nanoparticles and quantum dots for wound healing [ 29 , 30 ] are known and studied currently. The rate of release of these mentioned drugs from hydrogels is affected by the degree of cross-linking and the degree of swelling of the hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to the problem of targeted drug delivery in an organism. This will significantly reduce the toxicity of used pharmaceuticals and expand the range of their therapeutic, diagnostic, and medical application. This review presents a comparative description of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases. An analysis was made of most actual sources published for 2021–2022. The review is focused on the comparative characteristics of polymer gels in terms of their toxicity to cells and the release rate of drugs from nano-sized hydrogel systems, which are crucial initial features for their further possible application in mentioned areas of biomedicine. Different proposed mechanisms of drug release from gels depending on their structure, composition, and application are summarized and presented. The review may be useful for medical professionals, and pharmacologists dealing with the development of novel drug delivery vehicles.

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“…Drug-loaded hydrogels can be filled into the tumor site or cavity after the surgical resection of solid tumor to maintain the local drug concentration for a long time and greatly alleviate the possibility of recurrence of residual cancer cells [ 48 ]. Secondly, hydrogel can realize controllable drug releasing [ 49 – 51 ]. Hydrogels can respond to various stimuli [ 52 ], for example, light [ 53 ], near infrared light (NIR) [ 54 – 56 ], temperature [ 57 , 58 ], pH [ 59 ], magnetic field [ 60 ], enzymes [ 61 ], ionic strength and electric field.…”

Section: Introductionmentioning

confidence: 99%

Enhanced postoperative cancer therapy by iron-based hydrogels

Zhang

et al. 2022

Biomater Res

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Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron-based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.

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Intelligent hydrogel with both redox and thermo-response based on cellulose nanofiber for controlled drug delivery

Cited by 55 publications

References 56 publications

Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Enhanced postoperative cancer therapy by iron-based hydrogels

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