Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy

Abstract

As a noninvasive treatment modality, ultrasound (US)triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic therapy (PDT) in combating cancer. However, the SDT efficacy is still not satisfactory without oxygen (O 2 ) assistance. In addition, there is also much space to explore the SDT-based synergistic therapeutic modalities. Herein, a novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized. The hollow CuS shows a large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) to implement SDT. Moreover, the deposition of Pt not only enhances photothermal performance compared with those of CuS nanoparticles (NPs) due to the effect of the local electric field enhancement but also possesses nanozyme activity for catalyzing decomposition of endogenous overexpressed hydrogen peroxide (H 2 O 2 ) to produce O 2 that can overcome tumor hypoxia and augment the SDT-induced highly toxic reactive oxygen species (ROS) production for efficient cancer cell apoptosis. Importantly, the generated heat of Pt-CuS by 808 nm laser irradiation can accelerate the catalytic activity of Pt and elevate the O 2 level that further facilitates SDT efficacy. Interestingly, the thermally sensitive copolymer coated around the Janus can act as a smart switch to regulate the catalytic ability of Pt and control TAPP release that has a significant effect on modulating the therapeutic effect. The synergistic catalysis-enhanced SDT efficiency and highly photothermal effect almost realized complete tumor resection without obvious reoccurrence and simultaneously displayed a highly therapeutic biosafety. Furthermore, the high optical absorbance allows the as-synthesized Pt-CuS Janus for photoacoustic (PA) imaging and NIR thermal imaging. This work develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

“…[ 38 ] To elaborate the advantages of bimetallic Au@Rh, porous Rh nanoparticles with comparable sizes were also synthesized and used to evaluate their catalytic efficiency. In recognition of the high catalytic capacity of platinum (Pt)‐based nanomaterials in decomposing endogenous H 2 O 2 to improve tumor hypoxia, [ 14d,39 ] porous core–shell Au@Pt nanostructures were also similarly prepared and used as a benchmark to determine the catalytic efficiency of Au@Rh nanostructures. As confirmed by SEM, the prepared Rh nanoparticles and Au@Pt nanostructures both showed similar size and porous morphology to Au@Rh (Figure 1j inset).…”

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

“…[347] MnO x /TiO 2 -GR-PVP provided tumor microenvironment-sensitive T 1 -weighted MRI for IGS. [327] [348] TiO 2 @TiO 2−x reached a high photothermal-conversion efficiency (39.8%) at the NIR-II window (1064 nm), superior to that of MnO x /TiO 2 -GR-PVP (18.4%) upon 808 nm laser irradiation.…”

“…[324][325][326][327][328][329] Synergistic surgery with multimodal ablations have been expected to achieve high antitumor efficacy and good surgical outcomes. [324][325][326][327][328][329] Synergistic surgery with multimodal ablations have been expected to achieve high antitumor efficacy and good surgical outcomes.…”

Alloy, Janus and core–shell nanoparticles: numerical modeling of their nucleation and growth in physical synthesis

“…Envisioned applications of nanoparticles (NPs), including catalysis [1][2][3][4][5], optics [6][7][8][9][10][11], and medicine [12][13][14][15][16], depend on the ability to tailor their physical properties. A precise control of composition, shape, size distribution, and crystal structure should therefore be achieved during the synthesis [17][18][19].…”

“…Most recent research efforts went into raising the complexity of the material and multicomponent systems are increasingly researched in order to combine several properties within the same NP [20][21][22]. For binary systems, three different types of morphology are observed (1) alloy [23][24][25][26], (2) core-shell [27][28][29][30][31][32] and (3) Janus [11,[33][34][35].…”