Intelligent automated drug administration and therapy: future of healthcare

Sharma, Richa; Singh, Dhirendra Kumar; Gaur, Prerna; Joshi, Deepak

doi:10.1007/s13346-020-00876-4

Cited by 28 publications

(22 citation statements)

References 197 publications

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“…The controlled release system based on the dual-electrode microneedle patch only releases drugs under the condition of electric stimulation, and rarely releases drugs under the condition of no electric stimulation. In addition, the developed intelligent patch has copacetic mechanical properties, excellent electrochemical properties, and exceptional drug loading capacity, giving it wide application prospects in the clinical treatment of atopic dermatitis, with promising application potential in the direction of a closed-loop intelligent drug delivery system [ 61 ].…”

Section: Drug Releasementioning

confidence: 99%

Electrochemical Microneedles: Innovative Instruments in Health Care

2022

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As a significant part of drug therapy, the mode of drug transport has attracted worldwide attention. Efficient drug delivery methods not only markedly improve the drug absorption rate, but also reduce the risk of infection. Recently, microneedles have combined the advantages of subcutaneous injection administration and transdermal patch administration, which is not only painless, but also has high drug absorption efficiency. In addition, microneedle-based electrochemical sensors have unique capabilities for continuous health state monitoring, playing a crucial role in the real-time monitoring of various patient physiological indicators. Therefore, they are commonly applied in both laboratories and hospitals. There are a variety of reports regarding electrochemical microneedles; however, the comprehensive introduction of new electrochemical microneedles is still rare. Herein, significant work on electrochemical microneedles over the past two years is summarized, and the main challenges faced by electrochemical microneedles and future development directions are proposed.

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Section: Drug Releasementioning

confidence: 99%

Electrochemical Microneedles: Innovative Instruments in Health Care

2022

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“…• Dispositivos intrauterinos para liberación de medicamentos Los dispositivos intrauterinos para liberación de medicamentos, especialmente aquellos dedicados a la liberación de levonogestrel, se usan tanto como anticonceptivos como en afecciones (la bomba, la cánula, el reservorio, el sistema de adhesión, la zona de inserción, el monitor y el software), cuya función es la de control de la administración del medicamento, mientras que la responsable de la acción principal prevista, el manejo de la diabetes, es la insulina (120,121).…”

Section: Productos Combinados No Integradosunclassified

The borderline with medical devices in the current Spanish legal framework

Isern

Blanco

2022

an.ranf

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Medical devices cover a wide range of products essential for healthcare. In 2017 a new European regulation covering them was approved that fully applies from 2021 onwards. In it, their legal definition, classification, conformity assessment procedures, requirements for the clinical investigations that asses their safety and/or performance, and European database are specified. Despite the efforts for systematizing the legal definition of medical device in the new regulation, the determination of the legal status of devices known as ‘borderline products’, for which different regulations may apply (like in the borderline with food supplements, cosmetics, personal care products, biocides, personal protective equipment and consumer products), is not without difficulties. On account of their therapeutic significance, this review delves into the borderline between medicinal products and medical devices, and differentiates them from presentations where medicinal products and medical devices are used in combination, without constituting a borderline. Establishing updated definitions, promoting transparency in the sector and preventing conflicts of interest should motivate all stakeholders to the periodic review of the regulation in a field in continuous technological evolution and development.

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“…For instance, imaging agents and nanoparticle-modified drug compounds have noticeably enhanced contrast efficiency and treatment outcomes. The emergence of AI presents an attainable opportunity for pharmaceutical application including drug discovery, drug delivery, and nanomedicine for cancer treatment [16][17][18][19][20]. AI can play an important role in developing nanomedicine-based treatment outcomes [1].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Clinical Translation of Cancer Using Nanoinformatics

Soltani

Kashkooli

Souri

et al. 2021

Cancers

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Application of drugs in high doses has been required due to the limitations of no specificity, short circulation half-lives, as well as low bioavailability and solubility. Higher toxicity is the result of high dosage administration of drug molecules that increase the side effects of the drugs. Recently, nanomedicine, that is the utilization of nanotechnology in healthcare with clinical applications, has made many advancements in the areas of cancer diagnosis and therapy. To overcome the challenge of patient-specificity as well as time- and dose-dependency of drug administration, artificial intelligence (AI) can be significantly beneficial for optimization of nanomedicine and combinatorial nanotherapy. AI has become a tool for researchers to manage complicated and big data, ranging from achieving complementary results to routine statistical analyses. AI enhances the prediction precision of treatment impact in cancer patients and specify estimation outcomes. Application of AI in nanotechnology leads to a new field of study, i.e., nanoinformatics. Besides, AI can be coupled with nanorobots, as an emerging technology, to develop targeted drug delivery systems. Furthermore, by the advancements in the nanomedicine field, AI-based combination therapy can facilitate the understanding of diagnosis and therapy of the cancer patients. The main objectives of this review are to discuss the current developments, possibilities, and future visions in naoinformatics, for providing more effective treatment for cancer patients.

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Intelligent automated drug administration and therapy: future of healthcare

Cited by 28 publications

References 197 publications

Electrochemical Microneedles: Innovative Instruments in Health Care

Electrochemical Microneedles: Innovative Instruments in Health Care

The borderline with medical devices in the current Spanish legal framework

Enhancing Clinical Translation of Cancer Using Nanoinformatics

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