In recent years, increasing attention has been paid to interventions designed to enhance individuals’ sustainable development in learning by priming a growth mindset. The current study systematically explored the characteristics of message transformation in growth mindset interventions from the perspective of teaching and learning. According to a three-phase literature search (database, prominent researchers, and backtracking references), thirty-eight empirical studies investigating the efficacy of mindset interventions for adolescents of school age constitute the sample for the current literature review. The results indicate that a supportive but not-completely-saturated learning environment paves the way to implementing a mindset intervention. The three pedagogical characteristics that ensure successful interventions are: (1) Mutual interaction among the person, the context, and the theory to generate the message; (2) Iterative processes to ensure the message is delivered; and (3) a persuasive yet stealthy approach to facilitating its internalization. The findings inspire educators to design effective mindset interventions to enhance students’ learning. Theoretical and practical implications, limitations, and future directions are discussed.