Aims/hypothesis. Acute hypoglycaemia in humans causes general impairment of cognitive function, but information about its effects on more specific cognitive processes is limited. Methods. Basic aspects of auditory function were studied in 15 adults with uncomplicated Type I (insulin-dependent) diabetes mellitus. Two separate hyper insulinaemic glucose clamp procedures were done on different study days, in a counterbalanced fashion, either maintaining euglycaemia (blood glucose 5.0 mmol·l -1 ) or inducing hypoglycaemia (blood glucose 2.6 mmol·l -1 ). During each study, the subjects performed a battery of auditory and cognitive function tasks. Results. Hypoglycaemia caused deterioration in mental efficiency as assessed by Digit Symbol (p<0.001) and Trail Making B (p=0.004) tasks. Acute hypoglycaemia also caused deterioration in one of three measures of simple auditory processing (single-tone loudness, p=0.001) and in auditory temporal processing (p=0.007). The amplitude and latency of auditory N100, P200 and P300 event-related potentials were not affected, but the amplitude of the N240 potential was reduced during acute hypoglycaemia. Conclusion/interpretation. Our findings are consistent with other recognised disruptive effects of acute hypoglycaemia on sensory information processing in nondiabetic and diabetic adults, including adverse effects on auditory information processing in non-diabetic subjects. These derangements have implications for the everyday activities of people with Type I diabetes who are frequently exposed to acute hypoglycaemia. [Diabetologia (2003) 46:97-105] Keywords Hypoglycaemia, cognition, auditory information processing, auditory event-related potentials, Type I diabetes mellitus. . The pattern of impairment of these tests allows a general interpretation of the nature of cognitive dysfunction during hypoglycaemia, but provides little information about the impact of hypoglycaemia on specific brain processes such as basic sensory information processing.Two previous studies in our laboratory examined the ability of the brain to process visual information during acute hypoglycaemia. In one study [2] acute hypoglycaemia did not affect visual acuity or stereoscopic vision in non-diabetic subjects, but caused disPeople with Type I (insulin-dependent) diabetes mellitus are frequently exposed to episodes of acute hypoglycaemia. In experimental studies, a wide range of mental functions are impaired when arterialised blood