Integrity of the Ganglionated Plexi Is Essential to Parasympathetic Innervation of the Atrioventricular Node by the Right Vagus Nerve

Xhaët, Olivier; Roy, Luc De; Floria, Mariana; Deceuninck, Olivier; Blommaert, Dominique; Dormal, Fabien; Ballant, Elisabeth; Meir, Mark La

doi:10.1111/jce.13156

Cited by 8 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies have demonstrated that GPs on the right side act as “integration centers” and are capable of modulating the effect of stimulated left-sided GPs on AV and SA nodal responses [ 91 ]. HFS of the right inferior GPs has shown how they selectively innervate the AV node in humans [ 92 ]. As previously demonstrated in animal studies, ablation and mapping of right-sided GPs in humans with HFS can lower the number and magnitude of GP activity on the left side [ 93 ].…”

Section: Gp Ablation For Afmentioning

confidence: 99%

Ganglionated Plexi Ablation for the Treatment of Atrial Fibrillation

Avazzadeh

McBride

O’Brien³

et al. 2020

JCM

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system (ANS) plays an important role in the initiation and development of AF, causing alterations in atrial structure and electrophysiological defects. The intrinsic ANS of the heart consists of multiple ganglionated plexi (GP), commonly nestled in epicardial fat pads. These GPs contain both parasympathetic and sympathetic afferent and efferent neuronal circuits that control the electrophysiological properties of the myocardium. Pulmonary vein isolation and other cardiac catheter ablation targets including GP ablation can disrupt the fibers connecting GPs or directly damage the GPs, mediating the benefits of the ablation procedure. Ablation of GPs has been evaluated over the past decade as an adjunctive procedure for the treatment of patients suffering from AF. The success rate of GP ablation is strongly associated with specific ablation sites, surgical techniques, localization techniques, method of access and the incorporation of additional interventions. In this review, we present the current data on the clinical utility of GP ablation and its significance in AF elimination and the restoration of normal sinus rhythm in humans.

show abstract

Section: Gp Ablation For Afmentioning

confidence: 99%

Ganglionated Plexi Ablation for the Treatment of Atrial Fibrillation

Avazzadeh

McBride

O’Brien³

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Vagus nerve exerts its influence on the AVN through the epicardial fat pads that are primarily located on the posterior wall of the left atrium ( 2 ). The inferior vena cava-left atrium fat pad (namely also right inferior GP) located around the coronary sinus mainly provides vagal innervations and selectively innervates the AVN in humans ( 2 , 3 ). It was shown that high-frequency stimulation of the right anterior (or superior right atrial vagal GP) and left superior GP (or superior left atrial vagal GP) could also influence the AVN ( 3 ).…”

mentioning

confidence: 99%

“…The inferior vena cava-left atrium fat pad (namely also right inferior GP) located around the coronary sinus mainly provides vagal innervations and selectively innervates the AVN in humans ( 2 , 3 ). It was shown that high-frequency stimulation of the right anterior (or superior right atrial vagal GP) and left superior GP (or superior left atrial vagal GP) could also influence the AVN ( 3 ). In addition, the influence of the right anterior GP on the AVN appears to be more important than its influence on the left superior GP ( 2 , 3 ).…”

mentioning

confidence: 99%

“…It was shown that high-frequency stimulation of the right anterior (or superior right atrial vagal GP) and left superior GP (or superior left atrial vagal GP) could also influence the AVN ( 3 ). In addition, the influence of the right anterior GP on the AVN appears to be more important than its influence on the left superior GP ( 2 , 3 ).…”

mentioning

confidence: 99%

“…A functional neural pathway between the right vagus nerve and the AVN was identified ( 2 ), and the integrity of the GP seems to represent a mandatory interconnected network ( 3 ). In this study by Xhaet et al ( 3 ), the absence of any alteration in the ventricular rate in response to high-frequency stimulation of the right vagus nerve after the ablation of GP suggests that the right vagus nerve is not directly connected to the AVN and that the integrity of the GP is required to produce vagal effects on the AVN ( 3 ). Probably, there is no direct pathway between both the right and left vagus nerves and the AVN.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Ganglionated plexi interactions with atrio-ventricular node and right vagus nerve

Floria

Xhaët²,

Antohe³

2017

Anatol J Cardiol

Self Cite

View full text Add to dashboard Cite

Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study

Nemes,

Kormányos,

Orosz

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

IntroductionThe functioning of the left atrium (LA) is partly controlled by the neural system. It was purposed to evaluate correlations between the result of Ewing's 5 standard cardiovascular reflex tests (SCRTs) characterizing autonomic function and LA volumetric and functional features as assessed by three‐dimensional speckle‐tracking echocardiography (3DSTE) in healthy individuals.Materials and MethodsThe current study comprised 18 healthy volunteers being in sinus rhythm (mean age: 35 ± 12 years, 10 men). Measurement of blood pressure, ECG, 5 SCRTs, two‐dimensional Doppler echocardiography and 3DSTE were performed. These parameters were in normal ranges in all cases.ResultsFrom LA volumetric parameters, only systolic total atrial emptying fraction (r = 0.559, p = 0.037) and early diastolic passive atrial emptying fraction (r = 0.539, p = 0.047) correlated with systolic blood pressure response to standing representing sympathetic autonomic function. From LA strains, peak mean segmental LA radial strain (RS) (r = −0.532, p = 0.050), global and mean segmental LA circumferential strain (CS) (r = 0.662, p = 0.010 and r = 0.635, p = 0.015, respectively) representing systolic LA function correlated with Valsalva ratio representing parasympathetic autonomic function. Global LA‐RS (r = −0.713, p = 0.040) and LA‐CS (r = 0.657, p = 0.011) and mean segmental LA‐CS (r = 0.723, p = 0.003) at atrial contraction representing end‐diastolic atrial contraction showed correlations with Valsalva ratio, as well. Peak global and mean segmental LA‐CS (r = 0.532, p = 0.050 and r = 0.530, p = 0.050) and the same strains at atrial contraction (r = 0.704, p = 0.005 and r = 0.690, p = 0.006) representing systolic function and end‐diastolic atrial contraction correlated with systolic blood pressure response to standing representing both parasympathetic and sympathetic autonomic functions.ConclusionsSignificant correlations between features of vegetative autonomic function represented by Ewing's 5 SCRTs and specific LA functions represented by 3DSTE‐derived LA volume‐based functional properties and strains could be demonstrated in healthy adults.

show abstract

Integrity of the Ganglionated Plexi Is Essential to Parasympathetic Innervation of the Atrioventricular Node by the Right Vagus Nerve

Abstract: The integrity of the GP is essential for the right vagus nerve to exert physiological effects of on AVN in humans.

Cited by 8 publications

References 17 publications

Ganglionated Plexi Ablation for the Treatment of Atrial Fibrillation

Ganglionated Plexi Ablation for the Treatment of Atrial Fibrillation

Ganglionated plexi interactions with atrio-ventricular node and right vagus nerve

Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study

Contact Info

Product

Resources

About