Integrin α5 promotes tumor progression and is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma

Xie, Jian‐Jun; Guo, Jincheng; Wu, Zhi‐Yong; Xu, Xiu‐E; Wu, Jian‐Yi; Chen, Bo; Ran, Li-Qiang; Liao, Lian‐Di; Li, En‐Min; Xu, Li‐Yan

doi:10.1016/j.humpath.2015.09.029

Cited by 20 publications

(19 citation statements)

References 24 publications

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“…Migration, invasion, and proliferation ability could be significantly suppressed by knocking out the ITGA5 gene in GBM compared with the NC and control groups. These results were in accordance with the study conducted by Xie et al [20] who found that ITGA5 could promote growth, migration, and invasion of esophageal squamous cell carcinoma (ESCC) cells. However, we also found that multiple miRNAs (except miR-330-5p) could also target ITGA5, including miR-128, miR-31, miR-26a, and miR-205 [23,25,33,34].…”

Section: Discussionsupporting

confidence: 93%

“…ITGA5 has been widely accepted as involved in the process of invasiveness and tumorigenesis [20,32]. In our research, the expression level of ITGA5 in SiITGA5 group was down-regulated at both mRNA and protein levels, which means that ITGA5 might work as a facilitator in GBM.…”

Section: Discussionmentioning

confidence: 49%

“…In recent years, many studies have indicated that abnormal expression of ITGA5 is correlated to local tumor growth and metastasis, and can contribute to cancer invasion and migration [19,20]. Meanwhile, Tréhoux et al [26] and Mao et al [27] also found that miR-330 was related to many human cancers including pancreatic cancer, malignant melanoma, and prostate cancer [28].…”

Section: Discussionmentioning

confidence: 99%

“…Integrin α5 (ITGA5), which belongs to the integrin α chain family, binds predominantly with integrin β1 [20]. Besides, ITGA5 is considered one of the most plentiful proteins within the extracellular matrix (ECM), and function in cell surface adhesion and signaling [21].…”

Section: Introductionmentioning

confidence: 99%

“…Besides, ITGA5 is considered one of the most plentiful proteins within the extracellular matrix (ECM), and function in cell surface adhesion and signaling [21]. Several previous studies have indicated that ITGA5 can operate in certain cancers—including breast cancer, non-small cancer, and gastric cancer—by activating focal adhesion kinase to promote cell adhesion and migration [20,22–24]. For example, Zhang et al [25] found that ITGA5 can work with miR-31 in affecting cell invasion and metastasis of gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

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miR-330-5p suppresses glioblastoma cell proliferation and invasiveness through targeting ITGA5

Feng

et al. 2017

Bioscience Reports

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The present study intended to investigate the biological effects of miR-330-5p on glioblastoma (GBM) cell proliferation and invasiveness by targeting integrin α5 (ITGA5). The expressions of miR-330-5p and ITGA5 mRNA in GBM cell lines (U87, U251, and U373) and normal brain glial cell line (HEB) were detected using RT-qPCR. Protein expression of ITGA5 was examined using Western blot. The present study used MTT assay, colony formation assay, Transwell assay, wound healing assay, and flow cytometry analysis in order to determine the biological functions of GBM cells (including cell proliferation, invasion, migration, apoptosis, and cell cycle). The present study applied dual-luciferase reporter gene assay to identify the target relationship between miR-330-5p and ITGA5. miR-330-5p was low-expressed in GBM cell lines while ITGA5 was high-expressed compared with HEB. miR-330-5p could directly target ITGA5 as well as suppress its expression in GBM cells. Up-regulation of miR-330-5p and down-regulation of ITGA5 both have an inhibitory effect on cell proliferation, invasion, and migration. Meanwhile, they could also promote GBM cell apoptosis. miR-330-5p could suppress proliferation and invasion of GBM cells through targeting ITGA5.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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miR-330-5p suppresses glioblastoma cell proliferation and invasiveness through targeting ITGA5

Feng

et al. 2017

Bioscience Reports

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Revisiting laminin and extracellular matrix remodeling in metastatic squamous cell carcinoma: What have we learned after more than four decades of research?

Aleman

Young

Karam

et al. 2022

Molecular Carcinogenesis

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Patients with squamous cell carcinoma (SCC) have significantly lower survival upon the development of distant metastases. The extracellular matrix (ECM) is a consistent yet dynamic influence on the metastatic capacity of SCCs. The ECM encompasses a milieu of structural proteins, signaling molecules, and enzymes. Just over 40 years ago, the fibrous ECM glycoprotein laminin was identified. Roughly four decades of research have revealed a pivotal role of laminins in metastasis. However, trends in ECM alterations in some cancers have been applied broadly to all metastatic diseases, despite evidence that these characteristics vary by tumor type.

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Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix

Шевченко

Arnotskaya

Pak

et al. 2020

International Review of Neurobiology

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Integrin α5 promotes tumor progression and is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma

Cited by 20 publications

References 24 publications

miR-330-5p suppresses glioblastoma cell proliferation and invasiveness through targeting ITGA5

miR-330-5p suppresses glioblastoma cell proliferation and invasiveness through targeting ITGA5

Revisiting laminin and extracellular matrix remodeling in metastatic squamous cell carcinoma: What have we learned after more than four decades of research?

Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix

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