Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix

Шевченко, В. Е.; Arnotskaya, N. E.; Pak, Oleg; Sharma, Aruna; Sharma, Hari Shanker; Bryukhovetskiy, Andrey; Bryukhovetskiy, Igor

doi:10.1016/bs.irn.2020.03.005

Cited by 15 publications

(15 citation statements)

References 47 publications

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“…In this study, the function enrichment analysis based on COL5A1 and its co-expressed genes concluded a number of significant KEGG pathways and GO categories participating in the malignant behavior of proliferation, invasion, and migration in gliomas. For instance, the ECM receptor interaction pathway is considered to play an important role in glioma progression and correlate with tumor invasion ( 36 , 37 ). The focal adhesion pathway is also famous as an oncogenic pathway in gliomas ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas

Peng

et al. 2021

Front. Oncol.

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Glioma is the most common malignancy of the central nervous system. Although advances in surgical resection, adjuvant radiotherapy, and chemotherapy have been achieved in the last decades, the prognosis of gliomas is still dismal. COL5A1 is one of the collagen members with minor content but prominent functions. The present study examined the biological functions, prognostic value, and gene-associated tumor-infiltrating immune cells of COL5A1 through experiments and bioinformatics analysis. We found that the overexpression of COL5A1 was positively correlated with the increasing tumor malignancies and indicated poor prognosis in gliomas. Moreover, downregulation of COL5A1 could inhibit proliferation and migration of glioma cells and enhance their temozolomide sensitivities in vitro. Further bioinformatic analysis revealed that COL5A1 and its co-expressed genes participated in a number of pathways and biological processes involved in glioma progression. Finally, we evaluated the tumor-infiltrating immune cells of gliomas depending on COL5A1 and found that the percentages of the dendritic cells, which were known as the central mediator of tumor microenvironment in gliomas, were positively associated with the expression levels of COL5A1. Taken together, COL5A1 is an important biomarker and potential therapeutic target of gliomas.

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Section: Discussionmentioning

confidence: 99%

COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas

Peng

et al. 2021

Front. Oncol.

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“…Fibronectin 1 (FN1) is a central component of the extracellular matrix (ECM), which constructs the tumor microenvironment (TME) and participates in the invasion, migration ,immune in istrate, and metabolism of tumor cells [16,17]. By comparing the genetic differences between grade III and IV gliomas, it is found that the genes ELAV-like protein 1(ELAVL1) and FN1 may participate in the growth of gliomas through the PI3K-Akt signaling pathway, and ECM can be found to promote tumor invasion [18]. Similar to our results, COL3A1, FN1, MMP9 and other genes can be considered to play an important role in glioblastoma, and these genes are also mainly present in ECM [19].…”

Section: Discussionmentioning

confidence: 99%

Four Key Genes are Biomarkers Associated with Immunity in Neuroglioma

Yang¹,

Hao²,

Zhang³

et al. 2020

Preprint

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Background: Glioma is the most common intracranial tumor, with glioblastoma being the most malignant. However, its treatment is very few, and targeted therapy is an important breakthrough in treatment. Methods: Numerous genes are differentially expressed during the progression of glioma, some of which may play a key role. To find key genes, we analyzed three multi-sample microarrays (GSE4290, GSE54004, and GSE29796) in the GEO database to obtain intersection differential genes among them. We entered all DEGs into the STRING database and characterized the protein interactions of these DEGs as visual PPI networks by Cytoscape software. Also, we used the GEPIA2 and CGGAdatabase to predict the relationship between key genes and the prognosis of glioma patients.Results: A total of 222 up-regulated genes and 127 down-regulated genes were identified. Four genes(FN1, LAMB1, FAM20C, and COL6A1) were significantly negatively correlated with malignant glioma survival. Expression levels of four genes increased with the glioma grade. All gene expression is more common in IDH wild glioma and are enriched in the Mesenchymal subtype(AUC>0.8). In addition,they can be defined as hazard factors for glioma. We found that these genes were co-expressed and jointly involved in the infiltration of immune cells in tumors. Conclusion: In conclusion, FN1, LAMB1, FAM20C, and COL6A1 is associated with poor prognosis in glioma patients. These genes might be clinical targets of glioma immunotherapy.

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“…Как показывают собственные исследования (Bryukhovetskiy et al, 2020;Shevchenko et al, 2020), стимуляция дифференцированных клеток глиобластомы TGF-β достоверно уменьшает количество межклеточных контактов, увеличивает их подвижность и вызывает глубокую трансформацию молекулярного фенотипа опухолевых клеток в виде подавления синтеза адгезионного Е-кадгерина, оклюдина и клаудина 1, усиления продукции миграционного N-кадгерина, виментина, витронектина и других компонентов ВКМ, белков актин-миозинового комплекса и матриксных металлопротеаз MMP2, MMP9, MMP14, ADAMTS1.…”

Section: эпителиально-мезенхимальный переход и трансформирующий фактор роста βunclassified

“…Ангиогенез -важнейшее событие в биологии МГБ, которое напрямую связано именно с ОСК. Гиперэкспрессия белков сигнального пути РВ-ВКМ позволяет ОСК легко взаимодействовать с ремоделированным противовоспалительными цитокинами ВКМ, а способность к продукции металлопротеиназы LOXL2 более чем в 9 раз превосходит дифференцированные клетки МГБ (Shevchenko et al, 2020), что позволяет исключительно быстро модифицировать ВКМ и запустить ангиогенные процессы.…”

Section: межклеточные взаимодействия в ангиогенезе и иммуносупрессивная локальная микросредаunclassified

Глиобластома И Стволовые Клетки Костного Мозга

Брюховецкий¹,

Брюховецкий²,

Хотимченко³

et al. 2020

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Рецензенты: А.В. Полевщиков, д-р биол. наук, профессор, руководитель отдела иммунологии НИИ эксперимент. медицины Северо-Западного отделения РАН (г. Санкт-Петербург); М.И. Давыдов, д-р мед. наук, профессор, академик РАН, заслуженный деятель науки РФ, гл. онколог МЦ Управления делами Президента РФ, зав. каф. онкологии Первого Моск. гос. мед. университета им. И.М. Сеченова (г. Москва).

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Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix

Cited by 15 publications

References 47 publications

COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas

COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas

Four Key Genes are Biomarkers Associated with Immunity in Neuroglioma

Глиобластома И Стволовые Клетки Костного Мозга

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