Integrative study of cell damage and cancer risk in gas station attendants

Filho, Antônio P. R.; Silveira, Maruhen Amir Datsch; Nascimento, Camila Begui do; d’Arce, Luciana Paula Grégio

doi:10.1080/09603123.2017.1415305

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…Several studies failed to prove the short-term PMs exposure as a risk factor that could elevate daily cardiovascular hospital admissions or mortality [ 46 47 ]. One main reason for these inconsistencies is that the exposure-response relationships can be non-linear [ 23 24 25 ]. Moreover our previous study also indicated that this relationship between ASHD mortality and air pollution seemed to be non-linear [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…To further detect the gender-based differences in the vulnerability to air pollution, we used the Distributed lag nonlinear models (DLNMs) to explore the seasonal exposure-response relationships (during lag0-7) [ 22 ]. Considering the exposure-response relationships were not always linear or monotonic, we selected a natural spline function whose dfs were chosen according to the minimum unbiased risk estimator (UBRE) value [ 23 24 25 ].…”

Section: Methodsmentioning

confidence: 99%

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The Gender-Based Differences in Vulnerability to Ambient Air Pollution and Cerebrovascular Disease Mortality: Evidences Based on 26781 Deaths

Liu

Sun

et al. 2020

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The gender-based differences in the vulnerability to ambient air pollution have not been widely explored. This study aimed to investigate vulnerability differences to the short-term effects of PM 2.5 , PM 10 and O 3 between cerebrovascular diseases (CEVD) deaths of men and women. The general additive models (GAMs) and distributed lag non-linear models (DLNMs) were adopted, and both single-pollutant and two-pollutant models were performed to analyze the associations between ambient air pollution and daily CEVD deaths. Both models indicated that O 3 was the most suspicious pollutant that could induce excess CEVD deaths, and women tended to be more vulnerable to O 3. These results were confirmed by seasonal analysis, in which we also found both genders were more vulnerable to O 3 in winter. The exposure-response relationships revealed that women were usually more vulnerable to ambient air pollution than men, and the exposure-response curves differed significantly between genders. Our findings suggested that more attention should be paid on the adverse effects of ambient O 3 , and the protection of women CEVD population against air pollution should be emphasized.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Gender-Based Differences in Vulnerability to Ambient Air Pollution and Cerebrovascular Disease Mortality: Evidences Based on 26781 Deaths

Liu

Sun

et al. 2020

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“…Both groups (exposed and control) were submitted to the same procedure for sample collection and preparation. Collection of the oral mucosa and the preparation of slides were performed according to the protocol described by Thomas et al (1), with slight modifications already published by Silveira et al (8) and Filho et al (4). Briefly, buccal mucosa cells were collected by scraping the inner cheek using a sterille swab and placed in 3 ml of saline solution.…”

Section: Methodsmentioning

confidence: 99%

“…Human biomonitoring studies have tried to establish an association between the risk for future diseases and occupational exposure, life style and environmental and nutritional contamination (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In this context, car painting represents a potential occupational hazard, especially due to the known use of benzene, isocyanates, toluene and xylene (12,13).…”

mentioning

confidence: 99%

Increased DNA Damage, Instability and Cytokinesis Defects in Occupationally Exposed Car Painters

Filho¹,

Silveira²,

Demarco³

et al. 2019

In Vivo

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Background/Aim: Car painting is considered an occupational exposure job with high risk for cancer development, due to the association with harmful chemicals and mutagens. This study aimed to profile car painters occupationally exposed and determine its association with DNA damage and genomic instability. Materials and Methods: We collected a questionnaire and buccal cells of 74 individuals (37 car painters and 37 non-exposed workers) paired by age, alcohol and smoking habits. The number of pyknotic cells, karyolitic cells, karyorrhetic cells, condensed chromatin, binucleated cells, basal cells, differentiated cells (DIFF), micronucleated cells and nuclear buds were evaluated using the Buccal Micronucleus Cytome Assay protocol. Results: A statistically significant increase was observed in all parameters (p<0.05) in the exposed group, but DIFF showed a statistically significant decrease (p<0.001), compared to the control group. Conclusion: In association with the poor work environment and lack of personal and collective protective equipment, occupational exposure of car painters leads to high DNA damage, genomic instability and alterations in cellular kinetics.

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“…MNs represent chromosomes that have been separated from the mitotic spindle during impaired mitosis and contain a high proportion of centromeric material along with heterochromatin [25] . MNs can also be assessed from exfoliated buccal mucosa cells [26][27][28][29][30][31] or cultures of peripheral blood lymphocytes [32] .…”

Section: Micronucleus Testmentioning

confidence: 99%

Tumors due to chronic exposure to benzene and biomarkers of exposure

Alves¹,

Nunes²,

Melo³

et al. 2022

J Cancer Metastasis Treat

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Due to occupational activities, many people are exposed to carcinogenic airborne pollutants, such as benzene. Furthermore, benzene is also present in cigarette smoke. The main cancers associated with benzene, toluene, ethylbenzene, and xylenes (BTEX) are lung cancer and malignancies of the blood. At initial stages, lung cancer is often asymptomatic, but progression into metastasis is a huge clinical concern. We performed a review on possible biomarkers for monitoring increased genome instability and downregulation of the immune system in connection with overexposure to BTEX in a subgroup of workers being exposed to BTEX at Brazilian gas stations. The workers are subject to routine blood exams every semester; however, early genomic assessment is not routine. We evaluated available tests to be applied, including measuring benzene-derived metabolites in urine, determination of oxidative and inflammatory markers in blood, immunophenotypical profiling, micronucleus test, comet (single-cell gel electrophoresis) assay, (molecular) cytogenetics, chromosomal microarray, epigenetic-changes oriented tests, determination of mitochondrial (mt)DNA copy numbers, and studies on miRNA-level. However, no consensus was reached about their application and which test combination might be suited best.

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Integrative study of cell damage and cancer risk in gas station attendants

Cited by 5 publications

References 26 publications

The Gender-Based Differences in Vulnerability to Ambient Air Pollution and Cerebrovascular Disease Mortality: Evidences Based on 26781 Deaths

The Gender-Based Differences in Vulnerability to Ambient Air Pollution and Cerebrovascular Disease Mortality: Evidences Based on 26781 Deaths

Increased DNA Damage, Instability and Cytokinesis Defects in Occupationally Exposed Car Painters

Tumors due to chronic exposure to benzene and biomarkers of exposure

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