Since the beginning of 2010 there has been a boom of Public-Private Partnerships (PPPs) with a goal of Critical Infrastructure Protection and Resilience (CIP-R) and Emergency Management (EM) in North America and partly in Europe and Australia as well. Currently having PPPs as one of the main ways to cope with CI interdependencies through engaging all stakeholders in order to build 'full-spectrum' resilience, it is important to look up to the best practices. Previous research has set the theoretical base of PPPs and claimed their high potential for enhancing CIP-R that is vastly unexploited due to challenges in their establishment and management. It is now necessary to move forward to studying partnerships' practical side -common issues they face, ways to overcome them and concrete benefits they are able to bring. Through studying seven cases, this work compares different PPP approaches and their contribution to CIP-R. The study demonstrates how challenges are faced and solved in an innovative way and how the benefits are reached. It also shows approaches and joint activities that support information sharing and trust building as the main ingredients that hold partners together and enable progress in other aspects, from which both public and private parties may benefit. Starting from the findings and a subsequent analysis within and between the seven cases, the study proposes a framework for the development of regional CIP-R. programmes in the context of a PPP.