Integration of pluripotency pathways regulates stem cell maintenance in the
            <i>Arabidopsis</i>
            shoot meristem

Su, Ying; Zhou, Chao; Li, Ying Ju; Yang, Yu; Tang, Li; Zhang, Wen Jie; Yao, Wang Jinsong; Huang, Rongfeng; Laux, Thomas; Zhang, Xian Sheng

doi:10.1073/pnas.2015248117

Cited by 96 publications

(68 citation statements)

References 44 publications

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“…In Arabidopsis , SHOOT MERISTEMLESS ( STM ) encodes a KNOTTED1 (KN1)-related homeodomain protein and stm mutants show very severe phenotype lacking the shoot meristem, which is fatal to seedlings [ 40 ]. Recent studies have uncovered that STM integrates into WUS-CLV loop to modulate the stem cell homeostasis [ 41 ]. In grasses, KNOX proteins are also required for the maintenance of the proper size and activity of the stem cell niche ( Figure 2 and Table 1 ).…”

Section: The Genetic Regulation Of Transition From Sam To Immentioning

confidence: 99%

Molecular Insights into Inflorescence Meristem Specification for Yield Potential in Cereal Crops

Wang

Yang

2021

IJMS

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Flowering plants develop new organs throughout their life cycle. The vegetative shoot apical meristem (SAM) generates leaf whorls, branches and stems, whereas the reproductive SAM, called the inflorescence meristem (IM), forms florets arranged on a stem or an axis. In cereal crops, the inflorescence producing grains from fertilized florets makes the major yield contribution, which is determined by the numbers and structures of branches, spikelets and florets within the inflorescence. The developmental progression largely depends on the activity of IM. The proper regulations of IM size, specification and termination are outcomes of complex interactions between promoting and restricting factors/signals. Here, we focus on recent advances in molecular mechanisms underlying potential pathways of IM identification, maintenance and differentiation in cereal crops, including rice (Oryza sativa), maize (Zea mays), wheat (Triticum aestivum), and barley (Hordeum vulgare), highlighting the researches that have facilitated grain yield by, for example, modifying the number of inflorescence branches. Combinatorial functions of key regulators and crosstalk in IM determinacy and specification are summarized. This review delivers the knowledge to crop breeding applications aiming to the improvements in yield performance and productivity.

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Section: The Genetic Regulation Of Transition From Sam To Immentioning

confidence: 99%

Molecular Insights into Inflorescence Meristem Specification for Yield Potential in Cereal Crops

Wang

Yang

2021

IJMS

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“…The availability of tandemly arranged binding motifs (e.g., G-box) in the recognition site and a higher WUS protein abundance promotes the formation of the homodimeric state and enhances the binding affinity to the target gene promoter [ 83 , 84 , 85 ]. Additionally, WUS can form heterodimers with members of the HAIRY MERISTEM (HAM) TF family or with SHOOT MERISTEMLESS (STM) [ 86 , 87 ]. A model described by Gruel and coworkers [ 88 ] predicts that in HAM expressing cell layers, WUS forms WUS-HAM heterodimers, which, in contrast to the WUS monomer, represses the expression of CLV3.…”

Section: Formation Of Transcription Factor Complexes: a Way To Modulamentioning

confidence: 99%

“…A model described by Gruel and coworkers [ 88 ] predicts that in HAM expressing cell layers, WUS forms WUS-HAM heterodimers, which, in contrast to the WUS monomer, represses the expression of CLV3. In contrast, the interaction of WUS and STM can strengthen the binding of WUS to the CLV3 promoter [ 86 ]. The formation of different WUS complexes is one part of the regulatory processes to modulate expression of CLV3 in order to pattern the SAM and to define the stem cell region [ 88 ].…”

Section: Formation Of Transcription Factor Complexes: a Way To Modulamentioning

confidence: 99%

Meeting at the DNA: Specifying Cytokinin Responses through Transcription Factor Complex Formation

Leuendorf

Schmülling

2021

Plants

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Cytokinin is a plant hormone regulating numerous biological processes. Its diverse functions are realized through the expression control of specific target genes. The transcription of the immediate early cytokinin target genes is regulated by type-B response regulator proteins (RRBs), which are transcription factors (TFs) of the Myb family. RRB activity is controlled by phosphorylation and protein degradation. Here, we focus on another step of regulation, the interaction of RRBs among each other or with other TFs to form active or repressive TF complexes. Several examples in Arabidopsis thaliana illustrate that RRBs form homodimers or complexes with other TFs to specify the cytokinin response. This increases the variability of the output response and provides opportunities of crosstalk between the cytokinin signaling pathway and other cellular signaling pathways. We propose that a targeted approach is required to uncover the full extent and impact of RRB interaction with other TFs.

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“…The WUSCHEL-CLAVATA (WUS-CLV) feedback loop of Arabidopsis thaliana maintains stem cell homeostasis in shoot apical meristems (SAMs) 8 – 10 . Plant SAMs are the sources of all the above-ground parts of the plant 11 .…”

Section: Introductionmentioning

confidence: 99%

Functional analysis of the cotton CLE polypeptide signaling gene family in plant growth and development

Wan

Gao

et al. 2021

Sci Rep

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The CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (ESR)–RELATED (CLE) gene family encodes a large number of polypeptide signaling molecules involved in the regulation of shoot apical meristem division and root and vascular bundle development in a variety of plants. CLE family genes encode important short peptide hormones; however, the functions of these signaling polypeptides in cotton remain largely unknown. In the current work, we studied the effects of the CLE family genes on growth and development in cotton. Based on the presence of a conserved CLE motif of 13 amino acids, 93 genes were characterized as GhCLE gene family members, and these were subcategorized into 7 groups. A preliminary analysis of the cotton CLE gene family indicated that the activity of its members tends to be conserved in terms of both the 13-residue conserved domain at the C-terminus and their subcellular localization pattern. Among the 14 tested genes, the ectopic overexpression of GhCLE5::GFP partially mimicked the phenotype of the clv3 mutant in Arabidopsis. GhCLE5 could affect the endogenous CLV3 in binding to the receptor complex, comprised of CLV1, CLV2, and CRN, in the yeast two-hybrid assay and split-luciferase assay. Silencing GhCLE5 in cotton caused a short seedling phenotype. Therefore, we concluded that the cotton GhCLE gene family is functionally conserved in apical shoot development regulation. These results indicate that CLE also plays roles in cotton development as a short peptide hormone.

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Integration of pluripotency pathways regulates stem cell maintenance in the Arabidopsis shoot meristem

Cited by 96 publications

References 44 publications

Molecular Insights into Inflorescence Meristem Specification for Yield Potential in Cereal Crops

Molecular Insights into Inflorescence Meristem Specification for Yield Potential in Cereal Crops

Meeting at the DNA: Specifying Cytokinin Responses through Transcription Factor Complex Formation

Functional analysis of the cotton CLE polypeptide signaling gene family in plant growth and development

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