“…While PB has been shown to stimulate RDS in cultured mouse and rat hepatocytes, many studies from different laboratories have demonstrated that PB does not increase RDS in cultured human hepatocytes 20 , 65 , 66 , 67 , 69 , 70 , 71 , 72 , 73 , 74 . In addition to studies with PB, a number of other nongenotoxic rodent CAR-activators, including benfluralin, metazachlor, metofluthrin, momfluorothrin, the natural pyrethrins, nitrapyrin, and sedaxane, and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), have also shown no increased RDS in cultured human hepatocytes 20 , 65 , 66 , 71 , 72 , 73 , 74 , 75 , 76 , 77 . While the above studies were performed with monolayer cultures (i.e., two-dimensional cultures), a study by Plummer et al.…”