Application of humanized mice to toxicology studies: Evaluation of the human          relevance of the mode of action for rodent liver tumor formation by activators of the          constitutive androstane receptor (CAR)

Yamada, Tomoya

doi:10.1293/tox.2021-0027

J Toxicol Pathol

2021

DOI: 10.1293/tox.2021-0027

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Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Tomoya Yamada

Abstract: Short running head: Human relevance evaluation of CAR-mediated liver tumors Contents: 39 pages (including 95 references), 1 Table , and 5 Figures

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Cited by 5 publications

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Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR

Gährs

Schrenk

2021

Toxicology

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Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Abstract: Short running head: Human relevance evaluation of CAR-mediated liver tumors Contents: 39 pages (including 95 references), 1 Table , and 5 Figures

Cited by 5 publications

References 94 publications

Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR

Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR

Differentiated and non-differentiated HepaRG™ cells: A possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens

Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action

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