Motor vehicle crashes remain a leading cause of life and property loss to society. Autonomous vehicles can mitigate the losses by making appropriate emergency decision, and the crash injury severity prediction model is the basis for autonomous vehicles to make decisions in emergency situations. In this paper, based on the support vector machine (SVM) model and NASS/GES crash data, three SVM crash injury severity prediction models (B-SVM, T-SVM, and BT-SVM) corresponding to braking, turning, and braking + turning respectively are established. The vehicle relative speed (REL_SPEED) and the gross vehicle weight rating (GVWR) are introduced into the impact indicators of the prediction models. Secondly, the ordered logit (OL) and back propagation neural network (BPNN) models are established to validate the accuracy of the SVM models. The results show that the SVM models have the best performance than the other two. Next, the impact of REL_SPEED and GVWR on injury severity is analyzed quantitatively by the sensitivity analysis, the results demonstrate that the increase of REL_SPEED and GVWR will make vehicle crash more serious. Finally, the same crash samples under normal road and environmental conditions are input into B-SVM, T-SVM, and BT-SVM respectively, the output results are compared and analyzed. The results show that with other conditions being the same, as the REL_SPEED increased from the low (0–20 mph) to middle (20–45 mph) and then to the high range (45–75 mph), the best emergency decision with the minimum crash injury severity will gradually transition from braking to turning and then to braking + turning.