Integration of Flow Injection Analysis and Zeptomole-Level Detection of the Fe(II)-o-Phenanthroline Complex

Satô, Kiyoshi; Tokeshi, Manabu; Kitamori, Takehiko; Sawada, Tsuguo

doi:10.2116/analsci.15.641

Cited by 85 publications

(56 citation statements)

References 21 publications

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“…For example, flow-injection analysis was integrated on a single microchip, and the Fe(II)-ophenanthroline complex was determined at zeptomole levels. 21 The observed mixing time was about 20 s, which corresponded well to the calculated value, with the diffusion length assumed to be the channel size. Furthermore, a solvent-extraction system was also integrated on a glass microchip, 22 and the Febathophenanthrolinedisulfonic acid complex in aqueous solution was extracted in chloroform by forming an ion-pair product.…”

Section: Introductionsupporting

confidence: 85%

“…In 150 µm wide microchannels, for example, the mixing time was estimated to be about 20 s, which corresponds well to the molecular diffusion time. 21 Therefore, provided that mixing is performed only by diffusion, the smaller is the width of the microchannel, the faster can be the reaction completed. By using the fast mixing and diffusion properties of microchip analysis, an analytical system can be integrated into a chip with high performance.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fluorescent Derivatization of Nitrite Ions with 2,3-Diaminonaphthalene Utilizing a pH Gradient in a Y-shaped Microchannel

Odake

Tabuchi²,

Sato³

et al. 2001

ANAL. SCI.

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Section: Introductionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Fluorescent Derivatization of Nitrite Ions with 2,3-Diaminonaphthalene Utilizing a pH Gradient in a Y-shaped Microchannel

Odake

Tabuchi²,

Sato³

et al. 2001

ANAL. SCI.

View full text Add to dashboard Cite

“…(3), are at the same level for aqueous, organo-aqueous, and organo-aqueous extraction systems: the average normalized LOD of the latter is only 20% lower than that of the former. This shows that an actual increase in the sensitivity of extraction procedures results from high εTL and high excitation powers in these studies, [25][26][27][28][29][30][31][32][33][34] and not from the solvent properties. On the contrary, the normalized LODs for organo-aqueous mixtures exhibit the same LOD decrease as do the extraction procedures, but with much less changes in methodology compared to aqueous solutions.…”

Section: Normalized Limits Of Detectionmentioning

confidence: 84%

“…We have chosen Co and Fe determination because (i) the photometric methods for these metals are both sensitive and reliable; 24 (ii) they are based on the same reaction type, chelation; (iii) these methods cover all of the selected procedure types; and (iv) optimized TLS/TLM procedures have low practical LODs under batch and flow conditions. 3,4,[25][26][27][28][29][30][31][32][33][34][35][36] A total of 39 procedures (16 for Fe and 23 for Co) were considered.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Performance Parameters of Photothermal Procedures in Homogeneous and Heterogeneous Systems

et al. 2011

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The main types of analytical procedures used in thermal-lens spectroscopy and microscopy, which are based on photometric reactions in (i) aqueous solutions, (ii) organo-aqueous mixtures, (iii) polymer-containing (nonionic surfactants or polyethylene glycol) aqueous solutions, (iv) water-organic extraction systems, and (v) two-phase aqueous extraction systems, were compared from the viewpoint of both reproducibility and sensitivity. This comparison was made by examples of the determination of cobalt and iron for batch conditions, flow determination, and detection in HPLC, flow-injection analysis (FIA), and μFIA. It was revealed that for all five types, the real analytical efficiency (a decrease in the limit of detection (LOD) as compared to spectrophotometry) is primarily determined by the reaction conditions, provided that excitation of the thermal lens is the same. Aqueous solutions provide more efficient optimization of reaction conditions than do those in organo-aqueous solutions and solvent-extraction water-organic mixtures. The best results are achieved when shifting to polymer-containing aqueous solutions and two-phase aqueous extraction systems, which decreases in the LODs by a factor of 20 -100%.

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“…[10][11][12] The excitation beam was an Ar + laser of 488.0 nm which was mechanically chopped by a light chopper at 1.69 kHz. The probe beam was a He-Ne laser of 632.8 nm.…”

Section: Methodsmentioning

confidence: 99%

Molecular Transport between Two Phases in a Microchannel

et al. 2000

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Today, microfabricated devices (microchips) have attracted considerable attention because of their vast applicability and versatility. 1,2 Most published reports utilizing microchips to separate and detect analysis of interest have concentrated on using electrokinetically driven separation schemes. [3][4][5][6][7] Investigations from a different standpoint have been few in number. 8,9 However, microchips offer advantages concerning the scale merits of microspace, such as a short diffusion distance and the high interface-to-volume ratio, the specific interface area; we thus considered that they are an ideal tool to study molecular transport between two different phases, i.e., solvent extraction.In the present paper, we report on the first demonstration using a microchip to study molecular transport between two phases. ExperimentalWe have described the experimental apparatus and the principle of measurement for the thermal lens microscope (TLM) in detail previously. [10][11][12] The excitation beam was an Ar + laser of 488.0 nm which was mechanically chopped by a light chopper at 1.69 kHz. The probe beam was a He-Ne laser of 632.8 nm. Two laser beams were introduced coaxially into an optical microscope and tightly focused into a sample in a microchannel (100 µm×150 µm cross section) by an 20×0.65 NA objective lens. The excitation beam passing through the sample was separated from the probe beam by an optical narrow band-pass filter and a diffraction grating. The intensity of the transmitted probe beam after passing through a pinhole was detected by a photodiode. The photodiode current, amplified by a low-noise preamplifier (×100), was fed into a lock-in amplifier.The fabrication method for our glass chip was also previously published.11,12 Figure 1 shows the layout and dimensions of the glass chip.Nickel(II) chloride, dimethylglyoxime, ethanol, sodium acetate, acetic acid, hydrochloric acid, and chloroform were obtained from Wako Pure Chemical Industries, Ltd. and were used as received. Chloroform was of analytical grade. The other chemicals were of guaranteed grade, and the water used was from a Millipore Milli-Q system. A 2.5 mM nickel(II) stock solution was prepared by dissolving nickel(II) chloride in a small amount of hydrochloric acid and diluting with water. Aqueous solutions of Ni(II) were prepared at concentrations of 2.5 -50 µM by successive dilution with water. A stock solution of dimethylglyoxime was prepared by dissolving dimethylglyoxime in a small amount of ethanol and diluting to 1 mM with water. An aqueous buffer solution was prepared as follows. Acetic acid (2.4 ml) and 12.25 mg of sodium acetate were mixed and diluted to 250 ml with water. The Ni-complex sample solutions were prepared with a 1:1:1 mixing volume ratio of the nickel(II) solution, buffer solution and dimethylglyoxime solution. Results and DiscussionA Ni-dimethylglyoxime complex solution and chloroform in each reservoir were introduced into the solvent-extraction region by suction, as shown in Fig. 1. The two solutions did not mix w...

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Integration of Flow Injection Analysis and Zeptomole-Level Detection of the Fe(II)-o-Phenanthroline Complex

Cited by 85 publications

References 21 publications

Fluorescent Derivatization of Nitrite Ions with 2,3-Diaminonaphthalene Utilizing a pH Gradient in a Y-shaped Microchannel

Fluorescent Derivatization of Nitrite Ions with 2,3-Diaminonaphthalene Utilizing a pH Gradient in a Y-shaped Microchannel

Comparison of Performance Parameters of Photothermal Procedures in Homogeneous and Heterogeneous Systems

Molecular Transport between Two Phases in a Microchannel

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