Integration of capillary–hydrodynamic logic circuitries for built-in control over multiple droplets in microfluidic networks

Zaremba, Damian; Błoński, Sławomir; Korczyk, Piotr M.

doi:10.1039/d0lc00900h

Cited by 9 publications

(3 citation statements)

References 34 publications

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“…The microfluidic straight channel has the goal of transmitting the standing waves to the fluid flowing inside it. The channel is obtained by molding PDMS, a largely used soft polymeric material due to its optical transparency, ease of handling, and biocompatibility [ 49 ]. The chosen design for the microchannel allows for the display of one pressure node of the standing wave in correspondence with its longitudinal axis.…”

Section: Numerical Modelmentioning

confidence: 99%

Surface Acoustic Wave-Based Microfluidic Device for Microparticles Manipulation: Effects of Microchannel Elasticity on the Device Performance

Mezzanzanica,

Français,

Mariani

2023

Micromachines

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Size sorting, line focusing, and isolation of microparticles or cells are fundamental ingredients in the improvement of disease diagnostic tools adopted in biology and biomedicine. Microfluidic devices are exploited as a solution to transport and manipulate (bio)particles via a liquid flow. Use of acoustic waves traveling through the fluid provides non-contact solutions to the handling goal, by exploiting the acoustophoretic phenomenon. In this paper, a finite element model of a microfluidic surface acoustic wave-based device for the manipulation of microparticles is reported. Counter-propagating waves are designed to interfere inside a PDMS microchannel and generate a standing surface acoustic wave which is transmitted to the fluid as a standing pressure field. A model of the cross-section of the device is considered to perform a sensitivity analysis of such a standing pressure field to uncertainties related to the geometry of the microchannel, especially in terms of thickness and width of the fluid domain. To also assess the effects caused by possible secondary waves traveling in the microchannel, the PDMS is modeled as an elastic solid material. Remarkable effects and possible issues in microparticle actuation, as related to the size of the microchannel, are discussed by way of exemplary results.

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Section: Numerical Modelmentioning

confidence: 99%

Surface Acoustic Wave-Based Microfluidic Device for Microparticles Manipulation: Effects of Microchannel Elasticity on the Device Performance

Mezzanzanica,

Français,

Mariani

2023

Micromachines

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“…For example, different sized droplets can be either confined in asymmetric traps that can induce merging of pairs of droplets having different contents 19 or used as logic circuits. 20 The almost unlimited number of droplets that can be generated from a single device and the high speed at which droplet operations can be executed means that droplet-based microfluidic systems operate at exceptional throughput. This feature has been exploited to perform a range of challenging experiments, including digital PCR, 21,22 single cell sequencing, 23,24 directed evolution 25 and high-throughput single-cell analysis.…”

Section: Introductionmentioning

confidence: 99%

Towards an active droplet-based microfluidic platform for programmable fluid handling

et al. 2023

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“…In the context of microfluidics, the controllable generation of micro-droplets has enabled a wide range of applications, opening a new era for biological and chemical analysis and synthesis [1][2][3]. The formation of droplets is the first step to achieve in the pipeline in order to achieve versatile functionalities such as microreactors [4][5][6], mini-incubators [6][7][8], material templates [9][10][11], digital counters [12][13][14], or single cell platforms [15][16][17][18]. To date, droplet formation mechanisms in rectangular microchannels have been widely studied and can be classified in two main categories [19][20][21][22][23][24]: the mechanisms driven by hydrodynamic forces and those driven by surface tension.…”

Section: Introductionmentioning

confidence: 99%

Breaking one into three: surface-tension-driven droplet breakup in T-junctions

Zhou¹,

Ducimetière²,

Migliozzi³

et al. 2022

Preprint

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Droplet breakup is an important phenomenon in the field of microfluidics to generate daughter droplets. In this work, a novel breakup regime in the widely studied T-junction geometry is reported, where the pinch-off occurs laterally in the two outlet channels, leading to the formation of three daughter droplets, rather than at the center of the junction for conventional T-junctions which leads to two daughter droplets. It is demonstrated that this new mechanism is driven by surface tension, and a design rule for the T-junction geometry is proposed. A model for low values of the capillary number Ca is developed to predict the formation and growth of an underlying carrier fluid pocket that accounts for this lateral breakup mechanism. At higher values of Ca, the conventional regime of central breakup becomes dominant again. The competition between the new and the conventional regime is explored. Altogether, this novel droplet formation method at T-junction provides the functionality of alternating droplet size and composition, which can be important for the design of new microfluidic tools.

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Integration of capillary–hydrodynamic logic circuitries for built-in control over multiple droplets in microfluidic networks

Abstract: Passive integrated microfluidic logic structures allowing for the microelectronics-inspired programming of operations on sequences of droplets.

Cited by 9 publications

References 34 publications

Surface Acoustic Wave-Based Microfluidic Device for Microparticles Manipulation: Effects of Microchannel Elasticity on the Device Performance

Surface Acoustic Wave-Based Microfluidic Device for Microparticles Manipulation: Effects of Microchannel Elasticity on the Device Performance

Towards an active droplet-based microfluidic platform for programmable fluid handling

Breaking one into three: surface-tension-driven droplet breakup in T-junctions

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