Towards an active droplet-based microfluidic platform for programmable fluid handling

Cao, Xiaobao; Buryška, Tomáš; Yang, Tianjin; Wang, Jing; Fischer, P.; Streets, Aaron; Stavrakis, Stavros; deMello, Andrew J.

doi:10.1039/d3lc00015j

Cited by 6 publications

(2 citation statements)

References 58 publications

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“…Passive droplet generation methods rely on pressure-driven flow and channel geometry, whereas active droplet generation requires external aid from several active control sources [ 46 , 47 ]. Active methods have many advantages over passive methods, including high control of the droplet size and a short droplet generation time [ 48 , 49 , 50 ]. Active droplet generation can be achieved by controlling additional and intrinsic forces [ 16 ].…”

Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field.

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Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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“…[155] Thus, the most common approach to reduce the fabrication time focuses on multi-photon 3D laser printing of selected components for microfluidic devices which can be printed either on or directly inside of channels. [27,151,[156][157][158][159][160] The field of printing parts on microfluidic channels was recently expanded by printed components actively interacting with the surroundings. In this approach, microfluidic channels were, for example, coupled with imaging or served as delivery systems.…”

Section: D Printed Microfluidic Devicesmentioning

confidence: 99%

Recent Advances in Multi‐Photon 3D Laser Printing: Active Materials and Applications

Mainik,

Spiegel,

Blasco

2023

Advanced Materials

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Since the pioneering work of Kawata and colleagues in 1997, multi‐photon 3D laser printing, also known as direct laser writing, has made significant advancements in a wide range of fields. Moreover, the development and commercialization of photocurable inks for this technique have expanded rapidly. One of the current trends is the transition from static to active printable materials, often referred to as 4D microprinting, which enables a new degree of control in the printed systems. This review focuses on four primary application areas: microrobotics, optics and photonics, microfluidics, and life sciences, highlighting recent progress and the crucial role of active materials, including liquid crystalline elastomers, hydrogels, shape memory polymers, and composites, among others. It also addresses ongoing challenges and provides insights into the future prospects in the different fields.

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Integrating Renewable Microbial Fuel Cells in Dual In‐Line Package for Chip‐On‐Board Circuits

Elhadad,

Gao,

Choi

2023

Adv Materials Technologies

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Single‐use electrical systems represent the future of multiple fields such as diagnostic medical technologies, environmental studies, and biofuel manufacturing with significant advantages over conventional unrecyclable bulky systems that are partly disposable at best. Single‐use systems require miniaturized bio‐friendly energy sources that meet the recyclability or reusability requirement of the application without creating toxic waste. Herein, a storable, scalable, and single‐use electronics‐compatible bio‐battery that is designed and fabricated using completely reusable and recyclable components is developed. The battery is a dual‐in‐line package microbial fuel cell (DIP‐MFC) that can be activated on demand via the introduction of moisture through the anodic fluid chamber. The battery incorporates dormant bacteria cells on an abiotic stainless steel mesh that serves as the anode that attracts electrons being transferred from the biocatalyst. The DIP‐MFC uses the infestation of bacterial biofilm on a conductive anode to harness electrons and deliver electricity to selected circuit pins. A single DIP‐MFC continuously operates for 140 min with a maximum open circuit voltage of 0.55 V, which can be stacked and connected to match the power requirements of targeted electronics. The DIP nature of the proposed bio‐battery allows for simple integration of the MFC on conventional electronics boards through conductive pins.

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Towards an active droplet-based microfluidic platform for programmable fluid handling

Abstract: Droplet-based microfluidic systems have emerged as powerful alternatives to conventional high throughput screening platforms, due to their operational flexibility, high-throughput nature and ability to efficiently process small fluid volumes. However,...

Cited by 6 publications

References 58 publications

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Recent Advances in Multi‐Photon 3D Laser Printing: Active Materials and Applications

Integrating Renewable Microbial Fuel Cells in Dual In‐Line Package for Chip‐On‐Board Circuits

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