Integration of AdaptiSPECT: a small-animal adaptive SPECT imaging system

Abstract

AdaptiSPECT is a pre-clinical adaptive SPECT imaging system under final development at the Center for Gamma-ray Imaging. The system incorporates multiple adaptive features: an adaptive aperture, 16 detectors mounted on translational stages, and the ability to switch between a non-multiplexed and a multiplexed imaging configuration. In this paper, we review the design of AdaptiSPECT and its adaptive features. We then describe the on-going integration of the imaging system.

Molecular imaging in the College of Optical Sciences: an overview of two decades of instrumentation development

“…The back-end system has been ported to the modern PCI-E bus. [37] The control software operates all 16 cameras on a single CPU outfitted with a Tesla GPU card. We have implemented real-time GPU-powered ML estimation of event positioning based on our contracting-grid algorithm [38] such that a live display of all 16 projections are a routine part of the user interface, even though the list-mode acquisition is preserving all measured signals at full precision in accordance with the super-list-mode, or photon-processing , concept.…”

Fabrication of the pinhole aperture for AdaptiSPECT

“…This lead to imprecise pinhole placement, as well as surface imperfections. We have proposed a new manufacturing technique 5 utilizing conventionally machined parts, but incorporating tungsten inserts created using additive manufacturing. We implemented this technique in 3 steps: first we manufactured the high-magnification part of the collimator.…”

Task‐based design of a synthetic‐collimator SPECT system used for small animal imaging

“…The usage of pinhole SPECT systems has risen as the need for high-resolution preclinical imaging of small animals has grown. 1,2 In pinhole SPECT, the system resolution is a function of the object distance, detector distance, detector resolution, and pinhole radius. While reducing the pinhole radius results in a linear improvement in the spatial resolution, the sensitivity of the system decreases quadratically.…”

“…The usage of pinhole SPECT systems has risen as the need for high resolution preclinical imaging of small animals has grown[1][2]. In pinhole SPECT, the system resolution is a function of the object distance, detector distance, detector resolution, and pinhole radius.…”