Integrating treatments for methamphetamine abuse: A psychosocial perspective

Huber, Alice; Ling, Walter; Shoptaw, Steven; Gulati, Vikas; Brethen, Paul; Rawson, Richard A.

doi:10.1080/10550889709511142

Cited by 67 publications

(74 citation statements)

References 4 publications

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“…Special MA treatment services and rehabilitation programs, such as CBT, should be delivered for these females in methadone treatment services. Studies in the US indicate that CBT is effective for MA dependence (3,13).…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Tavakoli¹,

Effatpanah

Moradi

et al. 2018

Iran J Psychiatry Behav Sci

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Background: Methamphetamine (MA) dependence is a health concern in Iran (Persia). One main impacted group is female methadone patients. Objectives: The aim of this paper was to briefly report the prevalence of MA dependence among female methadone patients in 3 large cities of Iran. The other aim was to report the status of psychological well-being and social functioning among MA-dependent and non-MA dependent participants. Methods: In the first survey of Iran, 570 females were recruited from 38 main methadone clinics in Mashhad, Karaj, and Isfahan. A researcher-designed questionnaire was used to collect baseline demographics, details of MA use, and treatment history. Results: Of them, 266 females were MA-dependent. In other words, the prevalence of MA dependence among females was 46.6%. The length of MA dependence was 5 years. The adverse health impacts of high doses of methadone use were the main self-reported reasons for MA dependence. These adverse health impacts included depression (n = 118, 44.36%), oversleeping (n = 88, 33.08%), and low physical energy to do the housework (n = 60, 22.55%). However, lifetime MA treatment was only 25%. The prevalence of MA dependence was significantly associated with poor psychological well-being (P < 0.01) and social dysfunction (P < 0.01) among MA dependent females compared with non-MA dependent females. Conclusions: Methamphetamine dependence was common and associated with serious health problems. Special treatment services should be provided for these females.

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Section: Discussionmentioning

confidence: 99%

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Tavakoli¹,

Effatpanah

Moradi

et al. 2018

Iran J Psychiatry Behav Sci

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“…Due to the inaccuracies commonly associated with subjective self-reports and the variability in purity of street drugs, exact dose/frequency patterns are difficult to determine in recreational METH users (Angrist, 1994;Huber et al, 1997;Simon et al, 2002). METH abusers appear to vary widely in their dosage/frequency of use as suggested by self-report and post-mortem drug testing.…”

Section: Introductionmentioning

confidence: 99%

Modeling Human Methamphetamine Exposure in Nonhuman Primates: Chronic Dosing in the Rhesus Macaque Leads to Behavioral and Physiological Abnormalities

Madden

Flynn

Zandonatti

et al. 2004

Neuropsychopharmacol

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Acute high dose methamphetamine (METH) dosing regimens are frequently used in animal studies, however, these regimens can lead to considerable toxicity and even death in experimental animals. Acute high dosing regimens are quite distinct from the chronic usage patterns found in many human METH abusers. Furthermore, such doses, especially in nonhuman primates, can result in unexpected death, which is unacceptable, especially when such deaths fail to accurately model effects of human usage. As a model of chronic human METH abuse we have developed a nonlethal chronic METH administration procedure for the rhesus macaque that utilizes an escalating dose protocol. This protocol slowly increases the METH dosage from 0.1 to 0.7 mg/kg b.i.d. over a period of 4 weeks, followed by a period of chronic METH administration at 0.75 mg/kg b.i.d. ( ¼ total daily METH administration of 1.5 mg/kg). In parallel to human usage patterns, METH injections were given 20-23 times a month. This regimen produced a number of behavioral and physiological effects including decreased food intake and a significant increase in urinary cortisol excretion.

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“…Methamphetamine dependence directly or indirectly affects millions of Americans, and despite the efficacy of current treatments for some patients, relapse remains a significant problem (Huber et al, 1997;Rawson et al, 1999Rawson et al, , 2004Shoptaw et al, 1994). These studies, along with many others, underscore the challenge inherent in providing effective treatment to methamphetamine users.…”

Section: Introductionmentioning

confidence: 99%

Bupropion Reduces Methamphetamine-Induced Subjective Effects and Cue-Induced Craving

Newton

Roache

Garza

et al. 2005

Neuropsychopharmacol

139

126

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Bupropion is an antidepressant with stimulant properties, which inhibits the reuptake of dopamine (DA) and norepinepherine, and is purported to enhance DA neurotransmission. Bupropion is considered an appealing candidate medication for the treatment of methamphetamine dependence. The current laboratory study was set forth to assess the impact of bupropion treatment on the subjective effects produced by methamphetamine in the laboratory. We also assessed the effects of bupropion treatment on craving elicited by exposure to videotaped methamphetamine cues. A total of 26 participants were enrolled and 20 completed the entire study (n ¼ 10 placebo and n ¼ 10 bupropion, parallel groups design). Bupropion treatment was associated with reduced ratings of 'any drug effect' (po0.02), and 'high' (po0.02) following methamphetamine administration. There was also a significant bupropion-by-cue exposure interaction on General Craving Scale total score (po0.002), and on the Behavioral Intention subscale (po0.001). Overall, the data reveal that bupropion reduced acute methamphetamine-induced subjective effects and reduced cue-induced craving. Importantly, these data provide a rationale for the evaluation of bupropion in the treatment of methamphetamine dependence.

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Integrating treatments for methamphetamine abuse: A psychosocial perspective

Cited by 67 publications

References 4 publications

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Modeling Human Methamphetamine Exposure in Nonhuman Primates: Chronic Dosing in the Rhesus Macaque Leads to Behavioral and Physiological Abnormalities

Bupropion Reduces Methamphetamine-Induced Subjective Effects and Cue-Induced Craving

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