Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine

Zheng, Min; Liu, Shi; Li, Jing; Qu, Dan; Zhao, Haifeng; Guan, Xingang; Hu, Xiuli; Xie, Zhigang; Jing, Xiabin; Sun, Zaicheng

doi:10.1002/adma.201306192

Cited by 519 publications

(312 citation statements)

References 38 publications

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“…Of the carbon-family members, sp 2 carbon-based materials such as fullerene [4,5], carbon nanotubes [1,[6][7][8][9][10][11], carbon dots [12][13][14], and graphene [15][16][17][18], have been explored for promising applications in biomedicine, including drug delivery, gene transfection, photothermal therapy, photodynamic therapy, biosensing, and even tissue engineering [19][20][21]. For instance, the hollow space in fullerene/carbon nanotubes and large surface-to-volume ratio of graphene can be used for the encapsulation and intracellular delivery of therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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Nano-biotechnology provides highly efficient and versatile strategies to improve the diagnostic precision and therapeutic efficiency of serious diseases. The development of new biomaterial systems provides great opportunities for the successful clinical translation of nano-biotechnology for personalized biomedicine to benefit patients. As a new inorganic material system, mesoporous carbon biomaterials (

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Section: Introductionmentioning

confidence: 99%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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“…Luminescent carbon dots (CDs) have recently emerged as light‐emitting nanomaterials with a high PLQY, high photostability, excellent biocompatibility, and low toxicity, which can be easily produced by both top‐down and bottom‐up chemical synthesis methods with low cost;5 all this endow them distinct benefits for bioimaging6 and lighting applications 7. Compared with rare‐earth phosphors, CDs have much shorter luminescence lifetimes of just a few nanoseconds, which make them potential candidate as color converter for high modulation bandwidth in VLC.…”

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confidence: 99%

Hydrogen Peroxide‐Treated Carbon Dot Phosphor with a Bathochromic‐Shifted, Aggregation‐Enhanced Emission for Light‐Emitting Devices and Visible Light Communication

et al. 2018

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It is demonstrated that treatment of blue‐emissive carbon dots (CDs) with aqueous hydrogen peroxide (H2O2) results in the green emissive solid state CD phosphor with photoluminescence quantum yield of 25% and short luminescence lifetime of 6 ns. The bathochromic‐shifted, enhanced green emission of H2O2‐treated CDs in the powder is ascribed to surface state changes occurring in the aggregated material. Using the green emissive H2O2‐treated CD phosphor, down‐conversion white‐light‐emitting devices with cool, pure, and warm white light are fabricated. Moreover, using the green emissive CD phosphor as a color converter, a laser‐based white‐light source is realized, and visible light communication with a high modulation bandwidth of up to 285 MHz and data transmission rate of ≈435 Mbps is demonstrated.

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“…Wyniki uzyskane in vitro wskazują na doskonałą biokompatybilność takich kompleksów, aktywność przeciwnowotworową oraz możliwość ich śledzenia w komórkach. Z kolei wyniki badań in vivo potwierdzają możliwość śledzenia dystrybucji leku poprzez monitorowanie fluorescencji kompleksów CD-Oxa podanych systemowo myszom [53].…”

Section: Zastosowanie Kropek Kwantowych W Biologii I Medycynieunclassified

Carbon Quantum Dots as Potential Drug Carriers

Wiśniewski¹,

Roszek²,

Czarnecka³

et al. 2016

Eng. Prot. Environ.

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Recently, nanomaterials, especially carbonaceous, are gaining more and more attention due to the possibility of their direct use in various fields of science and industry. These nanoparticles possess unique properties that can be used in biomedical imaging and diagnostics. Great expectations are connected with using innovative nanomaterials as drug carriers. Carbon quantum dots (CQD) have high potential for biomedical applications. Compared with the controversial nanotubes, the toxicity of CQD is negligible and their small size allows for the penetration of the cell membrane barrier. The chemical nature and degree of surface graphitization are the basic parameters that define their biocompatibility. It has been proved repeatedly in the literature that the amorphous carbon quantum dots are more biocompatible than graphitic ones. A unique feature of quantum dots, used primarily in the diagnostics, is the ability to fluorescence. This feature allows to follow the distribution of quantum dots in the cells or even the whole body. Thus, connection of a therapeutic compound to the surface of the material also allows to track the path of the drug and moreover, facilitates its internalization. To date, most of the attention in the literature has been focused on drugs (mostly anti-cancer) immobilized on "inorganic" quantum dots, which are synthesized as heavy metal salts. The main drawback of these materials, however, are their toxicity and non-biodegradability. Therefore, the use of amorphous, biocompatible, biodegradable CQD seems to be a better solution. Also, their theranostic application has become the promising perspective.Keywords: activated carbon, powder, treatment, water, technology, development WprowadzenieKropki kwantowe (ang. quantum dots -QD) są to sferyczne nanokryształy o wielkości ziarna od 2 do 20 nm. QD są substancjami o właściwościach pośred-nich pomiędzy półprzewodnikami a cząstkami kwantowymi. Ich cechą charakterystyczną jest występowanie efektu ograniczenia kwantowego (ang. quantum confinement effect), co przekłada się na wyjątkowe właściwości absorpcji i emisji promieniowania. Oznacza to, że po wzbudzeniu QD energia emitowanych przez

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Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine

Cited by 519 publications

References 38 publications

Mesoporous carbon biomaterials

Mesoporous carbon biomaterials

Hydrogen Peroxide‐Treated Carbon Dot Phosphor with a Bathochromic‐Shifted, Aggregation‐Enhanced Emission for Light‐Emitting Devices and Visible Light Communication

Carbon Quantum Dots as Potential Drug Carriers

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