Integrating clinical/dermatoscopic findings and fluorescence in situ hybridization in diagnosing melanocytic neoplasms with less than definitive histopathologic features

Nardone, Beatrice; Martini, Mary C.; Busam, Klaus J.; Marghoob, Ashfaq A.; West, Dennis P.; Gerami, Pedram

doi:10.1016/j.jaad.2011.05.051

Cited by 12 publications

(3 citation statements)

References 21 publications

(27 reference statements)

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“…A single diagnostic technique cannot be relied upon to provide proper diagnosis but could potentially be helpful when combined with other modalities. To support this perspective, Nardone and colleagues found a combination of clinical/dermatoscopic findings and FISH enhanced detection in a subset of patients with early melanoma, including cases where Spitz nevus was on the differential [54].…”

Section: Spitz Nevimentioning

confidence: 99%

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012

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Pigmented lesions and melanocytic nevi are commonly evaluated lesions in pediatric dermatology clinics and the rising incidence of melanoma has increased public awareness of malignant potential. Diagnosis and management of pigmented lesions, especially dysplastic nevi, medium and large congenital melanocytic nevi (CMN), and Spitz nevi, can be particularly challenging. We summarize the recent literature for melanocytic nevi and pigmented lesions as relevant to the practice of pediatric dermatology with particular attention to dermatoscopic techniques, histopathologic interpretation, molecular biology, and management recommendations for CMN and Spitz nevi.

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Section: Spitz Nevimentioning

confidence: 99%

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012

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“…Combining multiple diagnostic modalities, such as dermatoscopy, histology, and molecular tools, has shown promise in enhancing early detection of melanomas. 107,108 However, all of these applications require further validation studies, with long-term follow-up. A comparison of the molecular approaches is presented in Table 2.…”

Section: Diagnosismentioning

confidence: 99%

Atypical Melanocytic Proliferations: A Review of the Literature

et al. 2018

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Because the diagnosis dictates treatment, it is incumbent to establish a diagnosis as definitive as possible, obtaining second or third opinions and using ancillary studies when appropriate. When the diagnosis remains uncertain, it is difficult to provide guidelines for treatment. Clinical care decisions for patients with an uncertain diagnosis are best done on a case-by-case basis weighing probabilities of adverse outcomes against potential benefits and risks from various treatment options.

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“…There is also the possibility of combining molecular and imaging technologies. For example, Nardone et al 79 reported that in a subset of early melanoma cases, combining dermoscopy and FISH may enhance the detection of early melanoma. Like all diagnostic tests, those reviewed here should be considered as adjunctive tools in reaching a diagnosis and management plan once all variables are considered-including clinical examination and additional information gleaned from other diagnostic modalities.…”

Section: Recommendationsmentioning

confidence: 99%