Integrated Whole-Body PET/MR Hybrid Imaging

Quick, Harald H.; Gall, Carl von; Zeilinger, Martin; Wiesmüller, Marco; Braun, Heinrich; Ziegler, Susanne; Kuwert, Torsten; Uder, Michael; Dörfler, Arnd; Kalender, Willi A.; Lell, Michael

doi:10.1097/rli.0b013e3182845a08

Cited by 95 publications

(59 citation statements)

References 28 publications

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“…Measurement of glucose metabolism by PET/MRI showed reproducible results and the PET image quality from PET/ MRI is not deteriorated when comparing with that from PET/CT scans [1][2][3][4]. Furthermore, PET/MRI provide superior soft tissue contrast to PET/CT and its roles for accurate diagnosis and evaluating therapeutic response in oncologic patients has been expanded [5,6].…”

Section: Introductionmentioning

confidence: 88%

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Kwon

Becker

Goo

et al. 2016

Nucl Med Mol Imaging

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The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. 18F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers. Combined analysis using structural information and functional/molecular information of tumors can draw additional diagnostic information based on PET/MRI. Further studies including determination of the diagnostic efficacy, optimizing the examination protocol, and analysis of the hybrid imaging results is necessary for extending the FDG PET/MRI application in clinical oncology.

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Section: Introductionmentioning

confidence: 88%

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Kwon

Becker

Goo

et al. 2016

Nucl Med Mol Imaging

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“…The hybrid PET/MR system is equipped with a full set of phased-array RF receiver coils that cover the patient's body and that connect to 32 independent RF receiver channels (Tim, Total imaging matrix, Siemens AG Healthcare Sector, Erlangen, Germany). 13 PET AC of the hybrid system is performed in two steps. Attenuation maps of MR-visible objects ("human" μ-map) are based on a Dixon-VIBE sequence.…”

Section: A Pet/mr Hybrid Systemmentioning

confidence: 99%

“…By now, first clinical trials with the whole-body PET/MR hybrid system have been conducted and compared to PET/CT acquisitions. [11][12][13] A major challenge in PET/MR imaging is PET attenuation correction (AC) (Ref. 14) a precondition to provide correct quantitative values with PET.…”

Section: Introductionmentioning

confidence: 99%

Towards integration of PET/MR hybrid imaging into radiation therapy treatment planning

et al. 2014

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Purpose: Multimodality imaging has become an important adjunct of state-of-the-art radiation therapy (RT) treatment planning. Recently, simultaneous PET/MR hybrid imaging has become clinically available and may also contribute to target volume delineation and biological individualization in RT planning. For integration of PET/MR hybrid imaging into RT treatment planning, compatible dedicated RT devices are required for accurate patient positioning. In this study, prototype RT positioning devices intended for PET/MR hybrid imaging are introduced and tested toward PET/MR compatibility and image quality. Methods: A prototype flat RT table overlay and two radiofrequency (RF) coil holders that each fix one flexible body matrix RF coil for RT head/neck imaging have been evaluated within this study. MR image quality with the RT head setup was compared to the actual PET/MR setup with a dedicated head RF coil. PET photon attenuation and CT-based attenuation correction (AC) of the hardware components has been quantitatively evaluated by phantom scans. Clinical application of the new RT setup in PET/MR imaging was evaluated in an in vivo study. Results: The RT table overlay and RF coil holders are fully PET/MR compatible. MR phantom and volunteer imaging with the RT head setup revealed high image quality, comparable to images acquired with the dedicated PET/MR head RF coil, albeit with 25% reduced SNR. Repositioning accuracy of the RF coil holders was below 1 mm. PET photon attenuation of the RT table overlay was calculated to be 3.8% and 13.8% for the RF coil holders. With CT-based AC of the devices, the underestimation error was reduced to 0.6% and 0.8%, respectively. Comparable results were found within the patient study. Conclusions:The newly designed RT devices for hybrid PET/MR imaging are PET and MR compatible. The mechanically rigid design and the reproducible positioning allow for straightforward CT-based AC. The systematic evaluation within this study provides the technical basis for the clinical integration of PET/MR hybrid imaging into RT treatment planning.

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“…The use of respiratory triggering or phase reordering can minimise any significant respiratory-related motion artefacts that may be present. Second, the implementation of MR-based motion-correction technologies to correct for gross patient motion and breathing in view of the relatively long PET data acquisition times seems promising [33]. Third, the susceptibility artefacts in DWI can be minimised by using half-Fourier acquisition single-shot turbo spin echo (HASTE) techniques [34].…”

Section: F-fdg Pet/ct With and Without Contrast In Liver Lesionsmentioning

confidence: 99%

Use of PET/MRI for identification and characterisation of liver lesions

Nasoodi

Syed

Afaq

et al. 2014

Clin Transl Imaging

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Magnetic resonance imaging (MRI) has long been considered the gold standard for evaluation of hepatic lesions. There has, however, been much recent interest in functional analysis of malignant lesions, and conventional imaging tests are no longer able to answer all the clinical questions. In the current era, anatomical characterisation, e.g. regarding size and density, is no longer deemed adequate. Combined imaging with PET/CT provides clarity and insight but at times can be challenging, especially in certain parts of the body such as the liver, pelvis and brain, where test sensitivity is compromised. PET/MRI, a hybrid imaging technology, can be used to improve upon the soft-tissue contrast offered by MRI and the biochemical and metabolic information provided by PET, with overall improvement in test sensitivity and hence increased diagnostic accuracy and improved tissue characterisation. Furthermore, various radiolabelled PET tracers can be used to improve the accuracy of staging, determination of the extent of disease, evaluation of treatment response, prognostic assessment and differentiation between post-therapeutic changes and tumour recurrence. In this article, we review the advantages of PET/MRI over conventional imaging in identifying and characterising liver lesions.

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Integrated Whole-Body PET/MR Hybrid Imaging

Cited by 95 publications

References 28 publications

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Towards integration of PET/MR hybrid imaging into radiation therapy treatment planning

Use of PET/MRI for identification and characterisation of liver lesions

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