Integrated urate sensors for detecting wound infection

Sharp, Duncan; Davis, James A.

doi:10.1016/j.elecom.2008.02.025

Cited by 27 publications

(16 citation statements)

References 10 publications

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“…The voltammogram recorded at the anodised fibre, in contrast, displays a well defined and easily quantifiable oxidation process. The change in profile is dramatic but is in keeping with previous work where electrochemical anodisation has been shown to aid both the resolution and the sensitivity of voltammetric processes [23,24]. The key question, however, is whether a similar effect could be achieved simply as a consequence of exposing the carbon surface to the laser.…”

supporting

confidence: 56%

“…Carbon fibres were encapsulated within a polyester resin laminate as described in previous work by the authors [23,24]. An electrode window was then created by rastering the laser across a pre-selected area of the polymer-fibre composite.…”

Section: Resultsmentioning

confidence: 99%

“…Electrochemical measurements were conducted using a µAutolab type III computer controlled potentiostat (Eco-Chemie, Utrecht, The Netherlands) using a three electrode configuration consisting of a glassy carbon working electrode (3mm diameter, BAS Technicol, UK), a platinum wire counter electrode and a 3 M NaCl Ag Electrochemical anodisation of carbon fibres was conducted using the procedures described previously [23,24] and typically involved amperometric oxidation (+2V, 15 minutes) in 0.1M sodium hydroxide solution.…”

Section: Methodsmentioning

confidence: 99%

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Laser-anodised carbon fibre: Coupled activation and patterning of sensor substrates

Ezekiel¹,

Sharp²,

Villalba³

et al. 2008

Journal of Physics and Chemistry of Solids

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A c c e p t e d m a n u s c r i p t The oxidation increases the proportion of oxygen species such as hydroxyl, carbonyl, carboxyl and quinones at the electrode surface [14]. These are well known to influence the wettability, surface reactivity, porosity and conductivity of the electrode [1,7,8,10]. It can also have the beneficial effect of increasing the availability of edge sites as a consequence of exfoliation / fracturing process that can, as with eppg electrodes, serve to increase electrode sensitivity towards particular analytes.Laser patterning of carbon encapsulated composites have been shown to provide a quick and versatile method of producing electrode sensor assemblies but the ability of the laser to positively influence the surface characteristics of the underlying fibre has yet to be evaluated. The adoption of the electrochemical anodisation A c c e p t e d m a n u s c r i p t H.B Ezekiel et al Nottingham Trent University May 20083 approach requires the introduction of a separate/discrete step in the construction of the electrode sensor and it is clear that combining the patterning/activation process would represent a considerable simplification in the development process. In the present investigation, the use of laser ablation as a means of removing protective polymer encapsulants to expose and activate the sensor surface in a single step is assessed. Experimental DetailsElectrochemical measurements were conducted using a µAutolab type III computer controlled potentiostat (Eco-Chemie, Utrecht, The Netherlands) using a three electrode configuration consisting of a glassy carbon working electrode (3mm diameter, BAS Technicol, UK), a platinum wire counter electrode and a 3 M NaCl Ag Electrochemical anodisation of carbon fibres was conducted using the procedures described previously [23,24] and typically involved amperometric oxidation (+2V, 15 minutes) in 0.1M sodium hydroxide solution. Results and DiscussionCarbon fibres were encapsulated within a polyester resin laminate as described in previous work by the authors [23,24]. An electrode window was then created by rastering the laser across a pre-selected area of the polymer-fibre composite. This has the effect of removing the polymer and exposing the fibre which can, in principle, be 4 kinetics at a substrate that is largely basal plane in structure. The voltammogram recorded at the anodised fibre, in contrast, displays a well defined and easily quantifiable oxidation process. The change in profile is dramatic but is in keeping with previous work where electrochemical anodisation...

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supporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Laser-anodised carbon fibre: Coupled activation and patterning of sensor substrates

Ezekiel¹,

Sharp²,

Villalba³

et al. 2008

Journal of Physics and Chemistry of Solids

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“…An area where this is apparent is within woundcare and burns management; a recent eDEPLHI study found that clinician's top research priorities included the development of wound diagnostics and the management of wound infections [1]. Research towards PoCT to enhance woundcare have been targeted through standard in-vitro diagnostic approaches, but also the emerging concept of smartbandages, capable of providing diagnostic information and detecting wound infection without the need for wound redressing using many electrochemical approaches [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Square Wave Voltammograms for pad-printed carbon electrodes for in 5M pyocyanin[1], pyocyanin free media[2], third-order polynomial baseline fitting lines [dashed lines], and residual plots for 5M pyocyanin[3], pyocyanin free media[4]. A. Britton-Robinson buffer (pH 7.0), B.…”

mentioning

confidence: 99%

Submicromolar quantification of pyocyanin in complex biological fluids using pad-printed carbon electrodes

Burkitt

Sharp

2017

Electrochemistry Communications

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Wearable Bioelectronics for Chronic Wound Management

Wang

Sani

Gao

2021

Adv Funct Materials

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Chronic wounds are a major healthcare issue and can adversely affect the lives of millions of patients around the world. The current wound management strategies have limited clinical efficacy due to labor-intensive lab analysis requirements, need for clinicians' experiences, long-term and frequent interventions, limiting therapeutic efficiency and applicability. The growing field of flexible bioelectronics enables a great potential for personalized wound care owing to its advantages such as wearability, low-cost, and rapid and simple application. Herein, recent advances in the development of wearable bioelectronics for monitoring and management of chronic wounds are comprehensively reviewed. First, the design principles and the key features of bioelectronics that can adapt to the unique wound milieu features are introduced. Next, the current state of wound biosensors and on-demand therapeutic systems are summarized and highlighted. Furthermore, the design criteria of the integrated closed loop devices are discussed. Finally, the future perspectives and challenges in wearable bioelectronics for wound care are discussed.

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Integrated urate sensors for detecting wound infection

Cited by 27 publications

References 10 publications

Laser-anodised carbon fibre: Coupled activation and patterning of sensor substrates

Laser-anodised carbon fibre: Coupled activation and patterning of sensor substrates

Submicromolar quantification of pyocyanin in complex biological fluids using pad-printed carbon electrodes

Wearable Bioelectronics for Chronic Wound Management

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