Integrated Time-Resolved Fluorescence and Diffuse Reflectance Spectroscopy Instrument for Intraoperative Detection of Brain Tumor Margin

Time‐resolved fluorescence (TRF) and diffuse reflectance spectroscopy (DRS) for margin analysis in breast cancer

“…) is used to integrate both excitation sources and collect the output signal from the TRF and DRS in a hand‐held device. For more information on the system, please refer to the methods section described by Nie et al .…”

“…The NADH/FAD red‐ox state of the tissue has also been examined in previous work and has been shown to be significantly higher in tumor versus normal breast tissue. The TRF technique has been performed to distinguish between glioma specimens from normal tissue . Fluorescence lifetime is an intrinsic feature of fluorophores.…”

Dual-modality optical biopsy of glioblastomas multiforme with diffuse reflectance and fluorescence: ex vivo retrieval of optical properties

“…A schematic and detailed description of the system can be found elsewhere. [65][66][67] All fibers used in DRS and SSF measurements have a core diameter of 200 μm and numerical aperture of 0.22. After DRS and SSF measurements were performed, the fluorescence decay was recorded using a 400-μm core optical fiber in the bundle.…”

Review of the potential of optical technologies for cancer diagnosis in neurosurgery: a step toward intraoperative neurophotonics

“…Depending on the energy of the light and the nature of the target tissue, some of these interactions, such as absorption by particular chemical bonds, can reflect the presence and quantity of well-understood tissue constituents and aid in tissue discrimination. 38,39 Optical imaging and spectroscopy have evolved from ancillary research tools to various diagnostic applications. Optical imaging, by far the oldest of bioimaging methods, helps us understand better by seeing better.…”