Review of the potential of optical technologies for cancer diagnosis in neurosurgery: a step toward intraoperative neurophotonics

Vasefi, Fartash; MacKinnon, Nicholas; Farkas, Daniel L.; Kateb, Babak

doi:10.1117/1.nph.4.1.011010

Cited by 33 publications

(25 citation statements)

References 81 publications

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Section: Introductionmentioning

confidence: 99%

“…At the macroscopic scale, 5‐Aminolevelunic acid induced protoporphyrin IX fluorescence imaging has significantly aided surgeons to improve biopsy and tumor surgery outcomes, yet non‐fluorescent satellite tumor cells are left undetected causing recurrence . For enhanced tumor visualization at the meso and microscale, other optical techniques are applied, usually through an endomicroscope . State of the art endomicroscopes can be equipped with confocal reflectance and fluorescence imaging , Raman spectroscopy and coherent anti‐Stokes Raman scattering (CARS) microscopy , fluorescence lifetime imaging (FLIM) and two‐photon microscopy .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Sibai

Mehidine

Moawad

et al. 2019

Journal of Biophotonics

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The surgical outcome of brain tumor resection and needle biopsy is significantly correlated to the patient's prognosis. Brain tumor surgery is limited to resecting the solid portion of the tumor as current intraoperative imaging modalities are incapable of delineating infiltrative regions. For accurate delineation, in situ tissue interrogation at the submicron scale is warranted. Additionally, multimodal detection is required to remediate the genetically and molecularly heterogeneous nature of brain tumors, notably, that of gliomas, meningioma and brain metastasis. Multimodal detection, such as spectrally‐ and temporally‐resolved fluorescence under one‐ and two‐photon excitation, enables characterizing tissue based on several endogenous optical contrasts. In order to assign the optically‐derived parameters to different tissue types, construction of an optical database obtained from biopsied tissue is warranted. This report showcases the different quantitative and semi‐quantitative optical markers that may comprise the tissue discrimination database. These include: the optical index ratio, the optical redox ratio, the relative collagen density, spectrally‐resolved fluorescence lifetime parameters, two‐photon fluorescence imaging and second harmonic generation imaging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Sibai

Mehidine

Moawad

et al. 2019

Journal of Biophotonics

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“…Newer microscope tools have been developed to enhance surgical visualization such as ORBEYE, a 4K three-dimensional (3D) microvideoscope 3D-Eye-Flex, BrightMatter Servo System (Synaptive Medical). [9][10][11][12][13][14] Sato et al 15 have reported on the use of laser as a lighting source with benefits of a decrease in the heat output and improved visualization. User interfaces for microscopes have also been the focus of some studies.…”

Section: Neurosurgical Visualizationmentioning

confidence: 99%

Mythri 1.0—Progress of an Indian Surgical Robot

Vazhayil

Voggu

Arumalla

et al. 2020

Indian Journal of Neurosurgery

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Neurosurgical procedures are performed using operating microscopes. The technology of most microscopes has not changed much over the past 60 years. The National Institute of Mental Health and Neurosciences and International Institute of Information Technology based at Bengaluru have embarked on joint collaboration for developing robot for neurosurgical applications. As a working prototype, robotic microscope Mythri 1.0 has been developed. An overview of the development process, working, and features of the device is presented in the article.

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“…Optical bioimaging techniques are most promising in this regard [9], where optical coherence tomography (OCT) [10] and multiphoton microscopy/tomography [11] are capable of visualizing cyto-and myelo-architectonics of the brain.…”

Section: сLinical Medicinementioning

confidence: 99%

Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues

Kiseleva¹,

Yashin²,

Моисеев³

et al. 2017

Sovrem Tehnol Med

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The aim of the study was to provide visual and quantitative evaluation of normal and tumorous brain tissue images obtained by crosspolarization optical coherence tomography (CP OCT) in comparative in vivo and ex vivo studies.Materials and Methods. The study was conducted using CP OCT -a non-damaging optical method of tissue structure imaging, which is capable of obtaining real time 3D images 2.4×2.4×1.25 mm in size within a short time of 26 s. The object of the study were normal and tumorous brain tissues of 12 experimental rats of a Wistar line: 4 -intact, 4 -with an induced malignant 101.8-glioma model and 4 -with an induced malignant C6-glioma model. In the intact rats, the cortex and the white matter were studied, in the rats with tumors -the central part of the tumor on the cortical surface, first in vivo and then ex vivo. Quantitative data evaluation of the CP OCT images involved calculation of attenuation coefficients for each tissue type.Results. A comparative qualitative image analysis of normal brain tissues and gliomas showed that the CP OCT images obtained ex vivo have the intensity and the attenuation rate (in both the initial and orthogonal polarizations) greater than those obtained in vivo. Quantitative analysis of the CP OCT images revealed significant statistical differences (p<0.02) between the attenuation coefficients from both tumors and the white matter in vivo (5. A comparison of the attenuation coefficients between the cortex and the white matter of the normal brain, as well as the white matter in the normal and malignant tissues, showed significant statistical differences both in vivo and ex vivo.Conclusion. The results of a qualitative comparative analysis of optical properties of normal and tumorous brain tissues using CP OCT allow us to conclude that the images obtained ex vivo show a full qualitative similarity with the structures observed with the intravital CP OCT study. Quantitative evaluation of CP OCT signals demonstrated a significant difference in the attenuation coefficient (p<0.005) between tumorous tissue, on the one hand, and normal white matter, on the other, both ex vivo and in vivo. However, when optical coefficients of tissues are evaluated in vivo, it is necessary to introduce adjustments based on the known differences between ex vivo and in vivo attenuation coefficients.

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Review of the potential of optical technologies for cancer diagnosis in neurosurgery: a step toward intraoperative neurophotonics

Cited by 33 publications

References 81 publications

Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Mythri 1.0—Progress of an Indian Surgical Robot

Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues

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