Integrated oral care contributes positively to the course of treatment of oncopediatric patients

Ribeiro, Isabella Lima Arrais; Costa, Raphael Cavalcante; Damascena, Lecidâmia Cristina Leite; Lucena, Nyellisonn Nando Nóbrega de; Maracajá, Paula Maria Bezerra; Santos, Fábio Gomes dos; Serpa, Eliane Batista de Medeiros; Sousa, Simone Alves de; Valença, Ana Maria Gondim

doi:10.1007/s00431-021-04024-z

Cited by 10 publications

(16 citation statements)

References 32 publications

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“…This contributes to longer professional care surveillance, which may reduce the occurrence of oral comorbidities. 49 Higher levels of gingival inflammation were associated with increased susceptibility to SOM. This data highlights the relevance of the OHEPP for patient compliance to self-care, reducing biofilm accumulation and ultimately decreasing the risks of SOM.…”

Section: Discussionmentioning

confidence: 99%

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A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

Sampaio

Bezerra

Santos

et al. 2023

Special Care in Dentistry

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ObjectivesTo assess the impact of an oral health education and preventive program (OHEPP) for pediatric cancer patients.MethodsThis was a single‐arm study with 27 children and adolescents undergoing antineoplastic treatments. Patients were followed up for 10 weeks, and their oral health conditions were evaluated using the Modified Gingival Index (MGI), Visible Plaque Index (VPI), and the modified Oral Assessment Guide (OAG). Audiovisual resources, storytelling, and ludic instruments were used to provide oral health education to patients and parents/caregivers.ResultsThe patients’ mean age was 9.41 (±4.49) years, and acute lymphoblastic leukemia was the most prevalent diagnosis (22.2%). Mean MGI and VPI values were 0.82 (±0.59) and 54.11% (±19.92%) at baseline and 0.33 (±0.29) and 19.83% (± 11.47%) after 10 weeks, respectively (p < .05). The mean OAG score was 9.51 (±2.54) and 36 cases (19.8%) of severe oral mucositis (SOM) were documented. Patients with higher MGI were more likely to develop SOM.ConclusionThe OHEPP had a positive impact on pediatric patients undergoing cancer therapy by improving their periodontal health, reducing biofilm accumulation, and preventing the development of OM lesions.

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Section: Discussionmentioning

confidence: 99%

“…In addition, patients from other cities may stay longer at the hospital, because traveling back and forth for short cycle intervals may be unfeasible. This contributes to longer professional care surveillance, which may reduce the occurrence of oral comorbidities 49 …”

Section: Discussionmentioning

confidence: 99%

A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

Sampaio

Bezerra

Santos

et al. 2023

Special Care in Dentistry

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“…It can suppress the expression of pro-inflammatory cytokines and promote the expression of anti-inflammatory cytokines following LPS-induced inflammatory response (28). Maintaining oral hygiene can reduce oral mucositis and delay the onset and duration of mucositis (42). Therefore, considering the effective role of oral condition before starting chemotherapy and oral hygiene in the development of oral mucositis, it seems that eliminating potential sources of oral infection such as gingivitis, caries or dental plaque is efficient in reducing the risk of mucositis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of Grape Seed Extract (GSE) on Oral Mucositis in Patients with Head and Neck Radiotherapy History- A Randomized Clinical Trial

et al. 2022

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Background: Mucositis is one of the most important complications of radiotherapy. Some factors such as type of treatment and degree of patient sensitivity affect mucositis occurrence. Objective: This research was implemented to evaluate the effect of grape seed extract on radiation-induced mucositis. Methods: This research is a double-blinded randomized clinical trial implemented on 78 patients undergoing head and neck radiotherapy in the oncology ward of Imam Reza Hospital of Tabriz. The patients were randomly divided into 2 groups, the intervention, and the control group. Each group included 39 patients. The intervention group used 2% grape seed extract mouthwashes and the control group used placebo mouthwashes. The mouthwashes were used 3 times a day for 2 weeks. For statistical analysis of collected data, SPSS 20 software was applied. Results: The results showed that according to the Friedman test, on the 10th and 14th days, mucositis grade and incidence had a significant difference between the intervention and control groups. Conclusions: The findings indicated that grape seed extract mouthwash in preventing radiation-induced mucositis was more effective than a placebo. Thus, this agent can be recommended as an appropriate medication to eliminate oral mucositis symptoms.

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“…Children were provided with daily oral healthcare and oral health education was provided for the caregivers during cancer treatment, as described elsewhere. 26 Only fluoride toothpaste (1100-1500 ppm) was commonly used without the administration of fluoride mouth rinses. Daily evaluations to monitor the condition of oral mucosa and oral hygiene were performed by a team of trained clinicians, dentistry students, and researchers.…”

Section: Participant Selection and Oral Healthcarementioning

confidence: 99%

Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

Araújo

Costa

Ribeiro

et al. 2021

Special Care in Dentistry

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Aims:To evaluate the unstimulated salivary flow (USF) and salivary colonization of total Streptococcus spp. (TS) and mutans-group (MS) in pediatric patients with hematological tumors. Correlations of salivary and microbiological changes with chemotherapy and patient-related factors were also verified. Methods and Results: Eligible children (n = 31) were evaluated before (control) and after (2, 5, and 10-weeks) the chemotherapy protocol was applied. Saliva samples were collected by the traditional spitting method to determine the USF (ml/min). Salivary TS and MS were determined by colony-forming units (CFU ) counts in a selective medium. The caries experience was evaluated by DMFT/dmft indexes. Data were submitted to Student's t-test, one-way ANOVA, and correlation tests (α = 0.05). The USF rate at baseline was 0.89 (±0.73) ml/min with up to 20% reduction during the follow-up and did not differ statistically during chemotherapy (p > .05). Chemotherapy did not modify the salivary TS load (p > .05), but induced a dysbiotic shift with higher MS counts (∼ 5 fold-increase) at 10-weeks (p < .05). There is a correlation of USF with age (r = .390) and SM load with caries experience (r s = −.540) at 5-weeks. Conclusion:Chemotherapy may promote a specific increase of mutans-group streptococci without changing the Streptococcus spp. load and unstimulated saliva flow. Correlation reinforced the need for further enlightenment about the chemotherapy mechanisms in the salivary and microbiological parameters.

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Integrated oral care contributes positively to the course of treatment of oncopediatric patients

Cited by 10 publications

References 32 publications

A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

Evaluation of the Effect of Grape Seed Extract (GSE) on Oral Mucositis in Patients with Head and Neck Radiotherapy History- A Randomized Clinical Trial

Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

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